Synthesis and analyses of injectable fluoridated-bioactive glass hydrogel for dental root canal sealing.

This study aimed to synthesize fluoride-doped bioactive glass (F-BG) based thermo-sensitive injectable hydrogel for endodontic applications. The structural and phase analyses were done with Fourier Transform Infrared spectroscopy and X-ray Diffraction, respectively. The setting time of prepared injectable was investigated at 21°C (in the presence and absence of an ultrasonic scalar) and at 37°C. Flowability was tested according to ISO-6876:2012 specifications, whereas injectability was checked by extrusion method using 21-, 22-, and 23-gauge needles. The in vitro bio-adhesion and push-out bond strength were studied on days 7 and 90 and compared with the commercially available TotalFill®. The ion release profile was analyzed for up to 30 days with Inductively Coupled Plasma Optical Emission Spectroscopy. The fluoride release analysis was conducted periodically for up to 21 days in deionized water and artificial saliva using an ion-selective electrode. The final setting time at 21°C, 21°C+ultrasonic scalar, and 37°C were 38.66±3.21, 29.12±1.23, and 32±3.46 min, respectively. The flowability was 25±3.94 mm, and the injectability coefficient was ≥70.3 for 22, 21, and 57% in a 23-gauge needle. Fluoride release in deionized water was found to be significantly higher than in artificial saliva and increased with time. A significant difference in bond strength was found between days 7 and 90, where the strength was increased, and a new apatite layer was formed on the tooth surface. A rapid release of calcium, phosphate, and silicon ions was seen initially, whereby the continuous release of these ions was observed for up to 30 days. The prepared F-BG injectable hydrogel has shown promising results and has the potential to be used as an endodontic sealer.

The trends of dental biomaterials research and future directions: A mapping review.

OBJECTIVE: This literature research aimed to compare, contrast and quantify the innovations in the most commonly used dental biomaterials. METHODOLOGY: Original research articles based on experimental dental biomaterials published between 2007 and 2019 were retrieved and reviewed. A search of electronic databases, PubMed, Scopus, and Web of Science indexed dental/biomaterials journals, has been conducted. The inclusion criteria in this research were: synthesis of experimental dental materials, whereas commercial dental materials, review articles, and clinical trials (case reports) were excluded. RESULTS: It was found that the amount of publications related to dental subgingival implants, computer-aided modeling ceramics, aesthetic restorative materials, adhesives cements, ceramics, bioceramics, endodontic materials, bioactive scaffolds, stem cells, and guided-tissue membranes had increased significantly from 2007. At the same time, the number of publications related to dental cements, silver amalgam, and dental alloys has decreased. For characterization of dental materials it was noted that mechanical properties were tested mostly for restorative materials. On the other hand, biological properties were most assessed for dental subgingival implants and endodontic materials, however, physical properties predominantly for bioceramics. CONCLUSION: It is concluded that to meet clinical demands there was more focus on restorative materials that provided better aesthetics, including resin composites, adhesive resin composites (luting cements), zirconia, and other ceramics. The boost in laboratory and animal research related to bioceramics was attributed to their regenerative potential. This current literature study will help growing researchers to consider and judge the direction to which research might be guided in order to plan prospective research projects.