RESUMO
OBJECTIVE: To investigate the correlation between bone metabolism markers, bone mineral density (BMD), and sarcopenia. METHODS: A total of 331 consecutive patients aged ≥ 60 years who were hospitalized between November 2020 and December 2021 were enrolled. Participants were divided into sarcopenia and non-sarcopenia groups according to the Asian Working Group on Sarcopenia criteria (AWGS, 2019). The clinical data, bone metabolism markers (ß-CTX, N-MID, and TP1NP), and BMD were compared between the two groups. RESULTS: Age, ß-CTX, and N-MID of the sarcopenia group were higher than those of the non-sarcopenia group (P < 0.05), but the BMD T values were lower than those of the non-sarcopenia group (P < 0.05). Binary logistic regression analysis showed that increased femoral neck BMD (FNBMD) was a protective factor for sarcopenia, while increased ß-CTX was a risk factor. Pearson/Spearman correlation analysis showed that the diagnostic indices of sarcopenia were positively correlated with FNBMD and negatively correlated with ß-CTX and N-MID. Multiple linear regression analysis revealed that BMI and FNBMD significantly positively affected muscle strength and appendicular skeletal muscle mass (ASM). The FNBMD significantly positively affected physical performance, while ß-CTX significantly negatively affected muscle strength, ASM, and physical performance. CONCLUSION: Increased FNBMD may be a protective factor against sarcopenia, and increased ß-CTX may be a risk factor. The FNBMD significantly positively affected the diagnostic indices of sarcopenia, while ß-CTX significantly negatively affected them. BMD and bone metabolism marker levels may be considered in early screening for sarcopenia.
RESUMO
Placusa pinearum, a newly described beetle species found living in pine shoot tunnels bored by the pine tip moth, Dioryctria rubella (Pyralidae), has potential as a vector to transport biological agents for controlling this moth pest of pine trees because of the high degree of niche overlap (co-occurrence) between them. In order to help determine the suitability of potential biological control vectors, it is useful to obtain knowledge concerning the intraspecific variation of the vector. We examined P. pinearum collected from 14 different geographical populations in China using morphological and molecular markers. An UPGMA dendrogram based on morphological characters showed divergence of populations of P. pinearum in a comparison of beetles from southwestern and 3 other geographic regions (central, northwestern, and eastern regions). We also compared 965-nucleotide sequences of the mitochondrial cytochrome oxidase subunit I gene from 56 individuals; 19 haplotypes were identified based on 28 polymorphic sites in this region. A Bayesian phylogenetic tree showed significant genetic divergence among the different populations in eastern China. In addition, absence of shared haplotypes, coupled with high pairwise FST values, demonstrated significant genetic divergence between the populations from the southwest and the other 4 main geographical regions (eastern, southern, central, and northwestern regions). Generally, we found the morphological divergence to be congruent with genetic divergence in these P. pinearum populations. This information should be useful for selection of suitable source materials in the species gene pool for future biological control programs.
