[Validation of the Pollard' s classification criteria (2010) for rheumatoid arthritis patients with fibromyalgia].

OBJECTIVE: To evaluate the sensitivity and specificity of Pollard' s classification criteria(2010) for the diagnosis of rheumatoid arthritis (RA) patients withfibromyalgia (FM) in Chinese patients, and to assess the clinical features and psychological status of RA-FM patients in a real-world observational setting. METHODS: Two hundred and two patients with rheumatoid arthritis were enrolled from the outpatients in Rheumatology and Immunology Department in Peking University People' s Hospital. All the patients were evaluated whether incorporating fibromyalgia translation occured using the 1990 American College of Rheumatolgy (ACR)-FM classification criteria. Forty two RA patients were concomitant with FM, while the other one hundred and sixty RA patients without FM were set as the control group. RESULTS: There was no significant difference in general demography between the two groups (P>0.05). In this study, the Pollard' s classification criteria (2010) for RA-FM in Chinese patients had a high sensitivity of 95.2% and relatively low specificity of 52.6%. Compared with those patients without FM, RA patients with FM (RA-FM patients) had higher Disease Activity Scale in 28 joints (DAS-28) score (5.95 vs. 4.38, P=0.011) and much more 28-tender joint counts (TJC) (16.5 vs.4.5, P < 0.001).RA-FM patients had worse Health Assessment Questionnaire (HAQ) score (1.24 vs. 0.66, P < 0.001) and lower SF-36 (28.63 vs. 58.22, P < 0.001). Fatigue was more common in RA-FM patients (88. 1% vs. 50.6%, P < 0.001) and the degree of fatigue was significantly increased in RA-FM patients (fatigue VAS 5.55 vs. 3.55, P < 0.001). RA-FM patients also had higher anxiety (10 vs.4, P < 0.001) and depression scores (12 vs.6, P < 0.001). erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), morning stiffness time and 28-swollen joint counts (SJC) showed no difference between these two groups. CONCLUSION: The Pollard' s classification criteria (2010) for RA-FM are feasible in Chinese rheumatoid arthritis patients. The Pollard' s classification criteria is highly sensitive in clinical application, while the relativelylow specificity indicates that various factors need to be considered in combination. RA patients with FM result in higher disease activity, worse function aland psychological status. RA patients with FM also have poorer quality of life. DAS-28 scores may be overestimated in RA patients with FM. In a RA patient thatdoes not reach remission, the possibility of fibromyalgia should be con-sidered.

Diversity and time delays induce resonance in a modular neuronal network.

This paper focuses on the resonance dynamics of a modular neuronal network consisting of several small-world subnetworks. The considered network is composed of delay-coupled FitzHugh-Nagumo (FHN) neurons, whose characteristic parameters present diversity in the form of quenched noise. Our numerical results indicate that when such a network is subjected to an external subthreshold periodic signal, its collective response is optimized for an intermediate level of diversity, namely, a resonant behavior can be induced by an appropriate level of diversity. How the probabilities of intramodule and intermodule connections, as well as the number of subnetworks influence the diversity-induced resonance are also discussed. Further, conclusive evidences demonstrate the nontrivial role of time-delayed coupling on the diversity-induced resonance properties. Especially, multiple resonance is obviously detected when time delays are located at integer multiples of the oscillation period of the signal. Moreover, the phenomenon of fine-tuned delays in inducing multiple resonance remains when diversity is within an intermediate range. Our findings have implications that neural systems may profit from their generic diversity and delayed coupling to optimize the response to external stimulus.

Electron spin resonance study of polycrystalline La(0.75)(Ca(x)Sr(1-x))(0.25)MnO(3) (x = 0, 0.45, 1).

Electron spin resonance (ESR) spectra of polycrystalline La(0.75)(Ca(x)Sr(1-x))(0.25)MnO(3) (x = 0, 0.45, 1) were studied within the temperature range 110 K≤T≤470 K. The temperature dependence of the ESR intensity for the samples is described by a thermally activated model in the paramagnetic regime. It is found that the activation energy in the orthorhombic phase is higher than that in the rhombohedral phase for La(0.75)(Ca(0.45)Sr(0.55))(0.25)MnO(3). It is suggested that a higher energy is required to destroy the correlated polarons due to the fact that correlated polarons only exist in the orthorhombic phase. This proposition is confirmed by the analysis of the ESR linewidth data, which can be well fitted by the model of adiabatic hopping motion of small polarons. In addition, it is found that, at a fixed temperature, the linewidth decreases with increasing Sr doping, which reveals that the structural tolerance factor has a significant effect on the linewidth.

Assessing lead thresholds for phytotoxicity and potential dietary toxicity in selected vegetable crops.

Lead tolerance and accumulation in shoots and edible parts varied with crop species and soil type. The critical Pb concentrations at 10% yield reduction were 24.71, 28.25, and 0.567 mg kg(-1) for pakchoi, celery, and hot pepper, respectively under hydroponic conditions, whereas were 13.1, 3.83, 0.734 mg kg(-1) grown in the Inceptisol and 31.7, 30.0, 0.854 mg kg(-1) in the Alluvial soil, respectively. Based on the threshold of human dietary toxicity for Pb, the critical levels of soil available Pb for pakchoi, celery, and hot pepper were 5.07, 8.06, and 0.48 mg kg(-1) for the Inceptisol, and 1.38, 1.47, and 0.162 mg kg(-1) for the Alluvial soil, respectively. Similarly, the total soil Pb thresholds were different from vegetable species and soil types.

Association study of an SNP combination pattern in the dopaminergic pathway in paranoid schizophrenia: a novel strategy for complex disorders.

Schizophrenia is a common mental disorder with a complex pattern of inheritance. Despite a large number of studies in the past decades, its molecular etiology remains unknown. In this study, we proposed a 'system-thinking' strategy in seeking the combined effect of susceptibility genes for a complex disorder by using paranoid schizophrenia as an example. We genotyped 85 reported single-nucleotide polymorphisms (SNPs) present in 23 genes for the dopamine (DA) metabolism pathway among 83 paranoid schizophrenics and 108 normal controls with detailed clinical and genetic information. We developed two novel multilocus approaches-the potential effective SNP combination pattern and potential effective dynamic effects analysis, by which three susceptibility genotype combinations were found to be associated with schizophrenia. These results were also validated in a family-based cohort consisting of 95 family trios of paranoid schizophrenia. The present findings suggest that the COMT and ALDH3 combination may be the most common type involved in predisposing to schizophrenia. Since the combination blocks the whole pathways for the breakdown of DA and noradrenaline, it is very likely to play a central role in developing paranoid schizophrenia.

[Paeonia Lactiflora injection in treating chronic cor pulmonale with pulmonary hypertension].

The changes of clinical features of blood stasis, hemorheology, arterial blood gas and hemodynamics which was determined by impedance cardiogram and pheopneumogram, hemorheologic examination, blood gaseous analysis and right heart catheterization were observed in 42 patients (male 35, female 7; age 64 +/- 16.5 years), 32 patients with decompensative chronic cor pulmonale (CCP), served as noninvasive methods group (NMG) treated by intravenous injecting 100% Paeonia lactifiora injection 5 ml per day, 10 patients with CCP as well as pulmonary hypertension, which was proved through right heart catheterization were considered as invasive methods group (IMG) treated by pulmonary artery injecting 100% Paeonia lactiflora 5 ml (one-time). After the treatment, the clinical features of blood stasis were improved significantly in NMG (P less than 0.05). Also the results of impedance cardiogram and pheopneumogram (such as: Q-B, B-Y interval and Q-B/B-Y ratio, cardiac output), the hemorheologic parameters (such as: blood viscosity, plasma viscosity, hematocrit and erythrocyte electrophoresis) and oxygen consumption of myocardium were improved significantly in NMG and IMG. In IMG, PAP was reduced by 0.71 +/- 0.27 kPa; PaO2 was promoted significantly in NMG. All of these have statistical significance (P less than 0.05 or 0.01). There are no statistical significance about the change of PaCO2, SaO2, blood pH and Bp (P less than 0.05).