1.
Angew Chem Int Ed Engl
; 53(35): 9284-8, 2014 Aug 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24989824
RESUMO
An efficient and convenient synthesis of α-allyl cyclic amidines has been achieved by applying a novel cascade reaction. Copper(I)-mediated inâ situ N-sulfonyl ketenimine formation from the reaction of a terminal alkyne with sulfonyl azide is followed by an intramolecular nucleophilic attack on the central carbon atom by an allylic tertiary amine, and then an aza-Claisen rearrangement takes place through a chair transition state to furnish the titled amidines with complete stereocontrol.