Utilization of dapsone and hemoglobin in the epithelial skin regeneration therapy of cutaneous loxoscelism: A case report and integrative literature review.

BACKGROUND: Loxosceles spp are arthropods found worldwide. Its bite may produce cutaneous loxoscelism (necrotic or edematous) or cutaneous-visceral loxoscelism. Depending on their severity and location, cutaneous forms are managed with local cold application and systemic administration of antihistamines, corticosteroids, antibiotics, polymorphonuclear inhibitors, and analgesics. OBJECTIVE: This study aimed to report a case of cutaneous loxoscelism and to identify the main dermatological manifestations associated with the Loxosceles spp bite. DESIGN AND SETTING: This case report and literature review was conducted in a Mexican university. METHODS: A detailed report on the medical management of a patient with cutaneous loxoscelism treated at the emergency department of a public hospital was published. Scopus, PubMed, Web of Science, and Google Scholar databases were searched to identify articles reporting cutaneous loxoscelism. The following keywords were used during the database search: "loxoscelism" OR "spider bite," OR "loxosceles" OR "loxosceles species" OR "loxosceles venom" OR "loxoscelism case report" AND "cutaneous" OR "dermonecrotic arachnidism." RESULTS: A 62-year-old female patient with cutaneous loxoscelism was treated with systemic dapsone and local heparin spray. Eighteen studies with 22 clinical cases were included in this systematic review. Of the 22 patients, 12 (54.5%) were men. L. rufescens was the predominant spider species. CONCLUSIONS: The administration of dapsone and heparin for the management of cutaneous loxoscelism demonstrated success in this case, with no sequelae observed. In general, the literature review indicated favorable outcomes in patients treated with antimicrobials and corticosteroids, with continuous healing of skin lesions. SYSTEMATIC REVIEW REGISTRATION: PROSPERO ID CRD42023422424 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422424).

Utilization of dapsone and hemoglobin in the epithelial skin regeneration therapy of cutaneous loxoscelism: A case report and integrative literature review

ABSTRACT BACKGROUND: Loxosceles spp are arthropods found worldwide. Its bite may produce cutaneous loxoscelism (necrotic or edematous) or cutaneous-visceral loxoscelism. Depending on their severity and location, cutaneous forms are managed with local cold application and systemic administration of antihistamines, corticosteroids, antibiotics, polymorphonuclear inhibitors, and analgesics. OBJECTIVE: This study aimed to report a case of cutaneous loxoscelism and to identify the main dermatological manifestations associated with the Loxosceles spp bite. DESIGN AND SETTING: This case report and literature review was conducted in a Mexican university. METHODS: A detailed report on the medical management of a patient with cutaneous loxoscelism treated at the emergency department of a public hospital was published. Scopus, PubMed, Web of Science, and Google Scholar databases were searched to identify articles reporting cutaneous loxoscelism. The following keywords were used during the database search: "loxoscelism" OR "spider bite," OR "loxosceles" OR "loxosceles species" OR "loxosceles venom" OR "loxoscelism case report" AND "cutaneous" OR "dermonecrotic arachnidism." RESULTS: A 62-year-old female patient with cutaneous loxoscelism was treated with systemic dapsone and local heparin spray. Eighteen studies with 22 clinical cases were included in this systematic review. Of the 22 patients, 12 (54.5%) were men. L. rufescens was the predominant spider species. CONCLUSIONS: The administration of dapsone and heparin for the management of cutaneous loxoscelism demonstrated success in this case, with no sequelae observed. In general, the literature review indicated favorable outcomes in patients treated with antimicrobials and corticosteroids, with continuous healing of skin lesions. SYSTEMATIC REVIEW REGISTRATION: PROSPERO ID CRD42023422424 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422424).

Clinical Evolution After Administering Antivenom in Patients With Loxoscelism.

Spiders are the most numerous arthropods of the arachnid class. More than 45 thousand species of spiders have been identified, and only a few are dangerous to humans. Among them, the "violin spider" or "brown spider" of the genus Loxosceles (family Sicariidae) has a worldwide distribution, and its bite can cause loxoscelism. Initial treatment of a Loxosceles spider bite includes application of local cold, rest, elevation of the extremity if possible, and systemic pharmacotherapy with antihistamines, corticosteroids, antibiotics, polymorphonuclear inhibitors, and analgesics or nonsteroidal anti-inflammatory drugs. During cutaneous or systemic loxoscelism, administration of Loxosceles antivenom (immunoglobulin (Ig)G F(ab')2 fragments) may be indicated to prevent progression to severe systemic phases. In this manuscript, we present three cases of patients with loxoscelism treated with the fabotherapeutic Reclusmyn®, developed and manufactured in Mexico. Two patients had a satisfactory outcome without severe skin or systemic damage. Only one patient with loxoscelism, despite early initiation of antivenom, had extensive skin lesions that healed satisfactorily, leaving only a non-disabling scar. Due to the global presence of this clinical problem, further studies are needed to establish local and general guidelines for the treatment and prevention of loxoscelism. This will allow health professionals to provide more efficient and higher quality medical care and feel supported in their decisions.

Gender Differences in Psychological Impact of the Confinement During the COVID-19 Outbreak in Spain: A Longitudinal Study.

The rapid spread of the coronavirus disease 2019 (COVID-19) has led the authorities to establish compulsory confinement for most of the Spanish population from March to May 2020. Severe isolation combined with the uncertainty and fear associated with the public health crisis can have a psychological impact on the general population. The aim of the current study was to compare possible gender differences in mental health and psychological measures throughout the confinement. One hundred and sixty-four Spanish participants (75% female; Mage = 39.8; SD = 13.5) completed the surveys at the beginning, middle, and end of the forced confinement. The psychological variables were associated with depressive, anxiety, stress, and intrusive/avoidance symptoms, as well as a total score for overall mental health, and a positive/negative affect measure. The results showed that although females had significantly higher scores than males in almost all measures at the beginning of the confinement, the gender differences were quickly vanishing away over time. In fact, intra-group analysis showed that while the female group significantly improved their results on most psychological measures, the male group improved on only one single measure. In summary, the results showed that although the female group started the confinement with higher levels of negative emotions (particularly symptoms of stress and avoidance) than the male group, these differences were significantly reduced in the first few weeks due to the overall improvement in the results of the female group.

Intervención en duelo y mindfulness / Grief intervention and Mindfulness

Resumen El presente estudio evalúa el efecto de una intervención adaptada del Programa Inteligencia Emocional Plena (PINEP) en adultos que han sufrido la pérdida de un ser querido. La intervención tuvo una duración de doce sesiones, de dos horas y media por semana. La muestra estuvo compuesta por 17 adultos de un rango de edad de entre 26 y 71 años (M= 50.59; SD = 14.44). Los participantes que completaron la intervención mostraron una mayor tolerancia al malestar desarrollando habilidades en mindfulnessy una disminución en ansiedad estado, ansiedad rasgo y depresión. De esta forma PINEP como programa de gestion emocional, promueve la aceptacion como estrategia psicologica, ante la vulnerabilidad emocional y sufrimiento psicológico.

Abstract This study assesses the effect of an intervention adapted from the Full Emotional Intelligence Program (PINEP, for its initials in Spanish) in adults who have suffered the loss of a loved one. The intervention lasted twelve sessions, two and a half hours per week. The sample consisted of 17 adults ranging in age from 26 to 71 years (M= 50.59; SD = 14.44). Participants who completed the intervention showed an increased tolerance to distress by developing mindfulness skills, and a decrease in state anxiety, trait anxiety, and depression. Therefore, PINEP, as an emotional management program promotes acceptance as a psychological strategy, in the face of emotional vulnerability and psychological suffering.

The Learning to Be Project: An Intervention for Spanish Students in Primary Education.

Despite the emphasis placed by most curricula in the development of social and emotional competencies in education, there seems to be a general lack of knowledge of methods that integrate strategies for assessing these competencies into existing educational practices. Previous research has shown that the development of social and emotional competencies in children has multiple benefits, as they seem to contribute to better physical and mental health, an increase in academic motivation, and the well-being and healthy social progress of children. This study aims at assessing the possible changes in children's self-esteem, socio-emotional competencies, and school-related variables after participating in the Learning to Be project (L2B) project. Methods: This quasi-experimental study included an intervention group (L2B) and a control group. The participants were 221 students in primary education (55.2% girls) between the ages of eight and 11 (M = 9.31; SD = 0.89). The L2B intervention program took place over a period of 5 months. The assessment was carried out twice, before and after the intervention through three main evaluation instruments: the Rosenberg's Self-Esteem questionnaire, the Socio-Emotional competence questionnaire (SEQ), and self-report scales for measuring school difficulties, school engagement, opinions about school, and school absence. Ten schools from different Spanish provinces participated. Results: The results indicate that those participants in the experimental group show higher self-esteem, better responsible decisions, and higher self-awareness than those in the control group. There were no other statistical differences between groups. Conclusions: The results of this work suggest that the implementation of the L2B program did not improve social and emotional competencies in primary school students. Further research related to how include formative assessment in SEL programs is needed.

Portuguese validation of the Adult Separation Anxiety-Questionnaire (ASA-27).

Adult separation anxiety disorder (ASAD) is characterized by developmentally inappropriate and excessive fear or anxiety concerning separation from those to whom the individual is attached. Despite the high rates of this diagnosis among Portuguese adults, there is a lack of measures to assess it. In this study, we assessed the psychometric properties of a Portuguese adaptation of the Adult Separation Anxiety questionnaire (ASA-27) on a sample of 267 adults (72.7% women) aged 18-80 years (M = 40.5, SD = 13.1). Factor structure, internal consistency, and convergence validity were examined. This study confirmed the single-factor structure of the Portuguese version of ASA-27. Consistency was high for the total sample (ω = .92) and by gender (ω = .93 and 92, men and women groups, respectively). The scale was positively related to the Portuguese version of State-Trait Anxiety Inventory (STAI) (r = .57, p< .001, for both State and trait anxiety scales) and Composite Codependency Scale total score (r = .29, p< .001). In addition, the ASA-27 total score showed incremental validity in the explanation of anxiety measured by STAI. In conclusion, results show that the Portuguese version of the ASA-27 is a reliable and valid measure of ASAD.

Psychological Impact of COVID-19 Confinement and Its Relationship with Meditation.

The objective of this study was to evaluate the psychological impact of confinement due to the COVID-19 pandemic, considering any protective factors, such as the practice of meditation or self-compassion, and their relationship with different lifestyles and circumstances of adults residing in Spain. A cross-sectional study was done using an anonymous online survey in which 412 participants filled out the Depression, Anxiety and Stress Scale-2; the Impact of Events Scale; and the Self-Compassion Scale-Short Form, reporting severe symptomatology of posttraumatic stress and mild anxiety and depression. Quality of cohabitation and age were found to be key variables in the psychological impact of confinement. The impact of confinement was more negative for those who reported very poor cohabitation as opposed to very good (F (3, 405) = 30.75, p ≤ 0.001, d = 2.44, r = 0.054) or for those under 35 years of age compared to those over 46 (F (2, 409) = 5.14, p = 0.006, d = 0.36). Practicing meditation was not revealed as a protective factor, but self-compassion was related to better cohabitation during confinement (F (3, 403) = 11.83, p ≤ 0.001, d = 1.05). These results could be relevant in designing psychological interventions to improve coping and mental health in other situations similar to confinement.

Mindfulness to regulate emotions: The Mindfulness and Emotional Intelligence Program (PINEP) and its adaptation to a virtual learning platform.

The present study examines the effect of the Mindfulness and Emotional Intelligence Program (PINEP), adapted to the virtual learning platform Moodle where participants receive Mindfulness training in 12 sessions lasting an hour and a half. The sample consists of 89 people, assigned randomly to a control group on the waiting list and to an experimental group that undertakes the training. The results indicate that the participants who completed PINEP showed improvement in the variables of health, empathy and mindfulness, in comparison with the participants of the group on the waiting list.

Actividad antibacteriana in vitro del propilenglicol ozonizado (Endozone®) sobre Enterococcus faecalis en conductos radiculares de dientes de bovino / In vitro antibacterial activity of ozonized propyleneglycol (Endozone®) on Enterococcus faecalis in root canals of bovine teeth

Objetivo: Determinar la actividad antibacteriana in vitro del propilenglicol ozonizado (Endozone®) y ultrasonido sobre Enterococcus faecalis (E. faecalis)en conductos radiculares de dientes de bovino. Métodos: El estudio fue de tipo experimental y se realizó en el laboratorio de microbiología de la Facultad de Biología de la Universidad Nacional del Altiplano-Puno. Las muestras fueron sembradas en agar bilis esculina, se contaminó dientes de bovino con E. faecalis a los cuales se les aplicó Endozone®y ultrasonido en distintos tiempos de acción luego de este procedimiento se realizó el recuento de desarrollo de colonias para cada diente mediante la técnica de observación directa estructurada. Resultados: El promedio de la actividad antibacteriana del Endozone®sobre E. faecalis fue de 92%, el promedio de la actividad antibacteriana del Endozone®aplicado con ultra-sonido por 10 segundos fue de 94,63%, aplicado por 20 segundos fue 95,01% y aplicado por 30 segundos fue 96,74%, observamos que la actividad antibacteriana es directamente proporcional al tiempo de aplicación, la prueba estadística de Kruskal-Wallis indicó diferencias significativas entre los diferentes tiempos de aplicación. Conclusiones: El Endozone® con aplicación de ultrasonido, tuvo mayor actividad antibacteriana que solo Endozone® sobre E. faecalis. La aplicación de Endozone®y ultrasonido por 30 segundos mostró mayor actividad antibacteriana. Palabras clave: Antibacterianos; Enterococcus faecalis; Ozono; Propilenglicol.

Objective: Determine the antibacterial activity in vitro of ozonized Propyleneglycol (Endozone ®) and ultrasound on Enterococcus faecalis (E. faecalis) in root canals of bovine teeth. Methods: The study was experimental, and carried out in the microbiology laboratory of the Faculty of Biology of the Altiplano University. The samples were seeded in bile esculin agar, bovine teeth were contaminated with E. faecalis was carried out, bovine teeth were contaminated with E. faecalisto which was applied Endozone® and ultrasound at different times of action, after this procedure the count of the colony development for each tooth was done using the structured direct observation technique. Results: The average of the antibacterial activity of Endozone® on Enterococcus faecaliswas 92%, the average antibacterial activity of Endozone® applied with ultrasound for 10 conds was 94,63%, applied for 20 seconds was 95,01% and applied for 30 seconds was 96,74%, we observed that the antibacterial activity is directly proportional to the time of application, the statistical test of Kruskall-Wallis indicated that there were significant differences between the different times of application. Conclusions: Endozone® with ultrasound application had a higher antibacterial effect than Endozone® on E. faecalis. The application of Endozone® and ultrasound for 30 seconds showed greater antibacterial activity. Keywords: Anti-bacterial agents; Enterococcus faecalis; Ozone; Propylene glycol.

The role of mindfulness in coping with recollections of acute stressors: a laboratory study.

BACKGROUND: There is mounting evidence regarding the psychological benefits of mindfulness. Yet, does mindfulness really help people to cope with the recollection of acute stressors? METHOD: To address this question, we examined the effects of trait mindfulness and experimentally induced mindfulness in cognitive and emotional responses to the recollection of an acute stressor among 76 female college students. RESULTS: Trait mindfulness was associated with fewer intrusive thoughts 24 hours after the stress induction, but not with affect balance immediately after the induction. Experimentally induced mindfulness showed the opposite pattern: it was associated with better affect balance immediately after the stress induction, but not with intrusive thoughts 24 hours later. CONCLUSIONS: These results suggest that even individuals predisposed to mindfulness may find it difficult to use mindfulness to cope effectively with memories of highly stressful events. Furthermore, our results suggest that the effects of brief mindfulness interventions may be too short-lived to really help people cope with such memories. Considered together, these findings highlight the importance of designing mindfulness-based interventions involving not only intensive practice but also specific training to help individuals use mindfulness to cope with acute stressors.

[Intra-laryngeal ectopic thyroid tissue. Report of one case and review of the literature]. / Tejido tiroideo ectópico intralaríngeo. Presentación de un caso clínico y revisión de la literatura.

A Ectopic thyroid is any thyroid tissue not located in his normal anatomic situation. There have been described four general groups within the upper aerodigestive tract: lingual, sublingual, thyroglossal and intralaryngotracheal. Intralaryngotracheal thyroid tissue is rare and constitute 7 per cent of all intratracheal tumours, and it represents a problem of diagnosis and management. The controversy about the genesis of this tumours remains. There are two established theories: "the malformation theory" and "the ingrowth theory". These tumours affect more frequently adult female. Intralaryngotracheal thyroid have been mainly reported on the posterior-left wall of the trachea. The most common clinical feature is stridor due to progressive upper airway obstruction. Up to 75% of the intralaryngotracheal goiters are associated with and external goiter. This paper reports a case of ectopic subglotic thyroid in a 42 year-old-female. The embryology, diagnosis and management of this tumours are discussed.

[Frontal ethmoid metastases of prostatic carcinoma. Report of one case and review of the literature]. / Metástasis fronto-etmoidal de adenocarcinoma prostático. Presentación de un caso clínico y revisión de la literatura.

Prostatic metastases in the nose and paranasal sinuses are rare. Less than 100 cases have been reported in the literature. Kidney are the commonest site of primary tumour, followed by lung and breast. Only 10 cases have previously been reported in the world literature. Prostatic metastases have been mainly reported in the sphenoid sinus. This paper reports one case of metastases of prostatic carcinoma in the fronto-ethmoid sinus in a 72 years old male. The clinical picture includes acute fronto-ethmoid right sinusitis, severe exophthalmos and chemosis. The CT scan showed extensive soft tissue filling the maxillary, ethmoid cells, sphenoid and frontal right sinuses, with subdural abscess. Biopsies from the fronto-ethmoid mass showed infiltration by adenocarcinoma with positive immunostaining for prostatic specific antigen. We also review the literature about metastases involving the nose and paranasal sinuses.