Influences of lncRNA HEIH and DKK3 on the clinical features and prognosis of gastric cancer.

PURPOSE: To detect differential expressions of HEIH and DKK3 in gastric cancer (GC) samples, and to elucidate their influences on clinical features and disease prognosis. METHODS: The expression levels of HEIH and DKK3 in GC tissues and adjacent normal ones (>5 cm) were detected by qRT-PCR. Correlation between HEIH and DKK3 levels in GC tissues was analyzed by Pearson's correlation analysis. Sensitivity and specificity of detecting HEIH and DKK3 levels in diagnosing GC were assessed by reactive oxygen species (ROC). 5-year survival in each patient was followed up. Risk factors of prognosis in GC patients were examined by Cox regression model. RESULTS: HEIH was upregulated, and DKK3 was downregulated in GC tissues, displaying a negative correlation. Both HEIH and DKK3 were correlated to tumor diameter, lymph node metastasis and TNM staging. Combined detection of HEIH and DKK3 levels showed high specificity and sensitivity in the diagnosis of GC. Tumor diameter, lymph node metastasis, TNM staging, HEIH and DKK3 levels were independent risk factors for the prognosis of GC. CONCLUSION: The upregulated HEIH and downregulated DKK3 in GC samples showed a negative correlation between each other. HEIH and DKK3 levels were closely linked to tumor diameter, lymph node metastasis and TNM staging in GC patients. These are promising biomarkers for predicting the prognosis of GC.

Clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning and prognosis analysis after rescue.

This study reports the clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning, and analyzes the prognosis after rescue.The general data of 68 patients with severe organophosphorus poisoning treated in our hospital were retrospectively analyzed. These patients were divided into 2 groups: treatment group, and control group. Patients in the control group received routine emergency treatment, while patients in the treatment group additionally received hemoperfusion plus hemodialysis on the basis of routine emergency treatment. The curative effects in these 2 groups and the prognosis after rescue were compared.Compared with the control group, atropinization time, recovery time of cholinesterase activity, recovery time of consciousness, extubation time, and length of hospital stay were shorter (P < .05); the total usage of atropine was significantly lower (P < .05); Glasgow Coma Score was significantly higher (P < .05); acute physiology and chronic health score (APACHE II) was significantly lower (P < .05); and mortality and poisoning rebound rate was significantly lower (P < .05) in the treatment group.Hemoperfusion and hemodialysis on the basis of routine emergency treatment for critical patients with organophosphorus poisoning can improve rescue outcomes and improve the prognosis of patients, which should be popularized.