1.
Bioorg Med Chem Lett
; 22(21): 6573-6, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23036954
RESUMO
Through scaffold morphing of a known Smoothened antagonist Antag691, a series of novel phenyl imidazole derivatives were developed. Structure-activity-relationship studies and lead optimization led to the discovery of potent, selective and orally bioavailable Smoothened antagonist 19 that is suitable for in vivo studies.