RESUMO
A 48-year-old man, who had worked as a welder for 30 years, was admitted to our hospital with bloody sputum. His chest CT scan showed diffuse centrilobular micronodules and fungus balls within cavities in the apices of both lungs. We diagnosed pulmonary aspergilloma associated with welder's lung in the apices of both lungs, by bronchoscopy. He was treated with oral antifungal drugs for 1 month, but he had massive hemoptysis. Bronchoscopy showed that the hemoptysis originated from the right upper lobe. We performed right upper lobectomy after right bronchial and intercostal arterial embolization. About 2 months after surgery, he had bloody sputum again. We then performed left bronchial and intercostal arterial embolization because bronchoscopy showed that the bloody sputum originated from the left upper lobe. His bloody sputum disappeared after the last embolization treatment. We report a rare case of pulmonary aspergilloma associated with welder's lung, with a discussion based on a review of the literature.
Assuntos
Doenças Profissionais/complicações , Pneumoconiose/complicações , Aspergilose Pulmonar/etiologia , Soldagem , Artérias Brônquicas , Embolização Terapêutica , Hemoptise/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Pneumonectomia , Aspergilose Pulmonar/terapia , Resultado do TratamentoRESUMO
We report the synthesis and metal ion-binding properties of DNA duplexes containing 4-N-substituted cytosine base pairs. Thermal denaturation studies of these modified DNA duplexes in the presence of various metal ions revealed that the DNA duplexes containing 4-N-carboxymethylcytosine (1) base pair(s) bound Ag (I), Ni(II), and Cu(II) ions. Moreover, ESI-TOF MS analysis of the DNA duplexes containing 1-1 base pair(s) in the presence of Cu(II) ions was consistent with one 1-1 base pair region binding one equivalent of Cu(II) ions. These results indicate that the DNA duplexes containing 1-1 base pair(s) may be useful as a new metal ion-binding motif.
