RESUMO
Osteosarcoma is the most common malignancy of mesenchymal cells mostly originating within long bones, but rarely in the jaws. This report illustrates a case of chondroblastic osteosarcoma in the region of anterior maxilla in a 58-year-old male patient previously treated for ossifying fibroma of the same site.
RESUMO
CONTEXT: Recurrent aphthous stomatitis (RAS) is the most common oral mucosal disease. However, the available therapies for RAS only relieve symptoms and do not provide a cure. AIMS: This study assessed the response to treatment with levamisole and low-dose prednisolone drug combination in patients with RAS. METHODS AND MATERIAL: Fifty RAS subjects were enrolled in the single-blind randomized placebo-controlled trial. Study medications were administered thrice daily for 3 consecutive days/week for 3 consecutive weeks. Patients in Group 1 received placebo, Group 2 received levamisole (50 mg) and Group 3 received levamisole (50 mg) and low-dose prednisolone (5 mg). Patients were followed up for 60 days after treatment. Response to treatment was assessed using the following clinical parameters: pain due to ulcers, number of ulcers/episode, size of ulcers, duration of ulcers, and frequency of ulcers (episodes/month). STATISTICAL ANALYSIS USED: MannWhitney U-test. RESULTS: A statistically significant improvement was noted in all parameters except for the size of ulcers in patients treated with levamisole alone and with combination of levamisole and low-dose prednisolone. There was no statistically significant improvement in the placebo group. Both active groups had significantly better improvement when compared to placebo group, while there was no significant difference between the two active groups. CONCLUSIONS: Levamisole alone and combination of levamisole and low-dose prednisolone are effective modes of therapy for RAS.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Anti-Inflamatórios/administração & dosagem , Levamisol/uso terapêutico , Prednisolona/administração & dosagem , Estomatite Aftosa/tratamento farmacológico , Adjuvantes Imunológicos/administração & dosagem , Adolescente , Adulto , Combinação de Medicamentos , Feminino , Seguimentos , Humanos , Levamisol/administração & dosagem , Masculino , Pessoa de Meia-Idade , Medição da Dor , Placebos , Recidiva , Método Simples-Cego , Estomatite Aftosa/patologia , Fatores de Tempo , Adulto JovemRESUMO
Osteopetrosis is a rare inherited genetic disease characterized by sclerosis of the skeleton caused by the absence or malfunction of osteoclasts. Three distinct forms of the disease have been recognized, autosomal dominant osteopetrosis being the most common. Autosomal dominant osteopetrosis exhibits a heterogeneous trait with milder symptoms, often at later childhood or adulthood. The aim of this case report is to present the clinical and radiographic features of a 35-year-old female patient with autosomal dominant osteopetrosis type II who exhibited features of chronic generalised periodontitis, and the radiographs revealed generalised osteosclerosis and hallmark radiographic features of ADO type II, that is, "bone-within-bone appearance" and "Erlenmeyer-flask deformity."