[Contemporary approaches in evaluation of pro- and antioxidant status in combined forms of occupational diseases due to functional overstrain].

Complex evaluation covered parameters pro- and antioxidant system in some somatic diseases, mostly in arthrosis and polyneuropathies due to occupational factor of functional overstrain. The results obtained prove influence of prolonged occupational functional overstrain causing excessive free oxidative radicals formation, strain of antioxidant status and subsequent oxidant stress--that is clinically manifested with "mutual burden" syndrome in combined occupational diseases.

[Features of changes in joints structure, in lipid spectrum and vascular remodelling with occupational arthrosis].

Studies covered features of intraarticular cartilage and soft tissue components of knee joints, lipid spectrum and structures of peripheral arteries in occupational knee osteoarthrosis. Findings are relationships between lipid metabolism disorders and frequency of cartilage degeneration in knee joints, with vascular remodelling parameters.

[Prospects of hi-tech medicine development in occupational pathology (exemplified by joints diseases model)].

Recommendations for patients with occupational locomotory disorders include ultrasonography, diagnostic and therapeutic arthroscopy, target therapy of systemic osteoporosis with monohydrate zoledronic acid (aclasta)--that enables prolong remission (up to 46.2 months).

[Innovative approaches to diagnosis and treatment of occupational diseases (on joint diseases model)].

The authors studies features of structure and functional state of knee joints in occupational diseases. Findings are peripheral circulatory disorders, changes in all hemostasis levels, with trend to increased platelets aggregation, hyperfibrinogenemia, hypercoagulation and fibrinolysis system disorders. Considering the diagnosis, the authors specified treatment algorithms for occupational osteoarthrosis.