1.
Chemistry
; 23(3): 533-536, 2017 01 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27805289
RESUMO
A facile and convergent approach has been developed for the stereoselective construction of biologically important polyhydroxylated 2-acyl indolizidine framework using aza-Cope rearrangement-Mannich cyclization as a key step. The generality of this methodology is demonstrated with various lactol-tosylates derived from carbohydrates. The presented method provides an easy access to indolizidine- and tetrahydroindolizine-based iminosugar derivatives in good yields.