RESUMO
Rare donor programs are critically important for those patients with rare phenotypes who have produced the associated alloantibodies that necessitate the provision of rare blood components. We describe the American Rare Donor Program (ARDP) and its establishment, members, and policies. The specific phenotypes meeting the ARDP criteria for inclusion are described. Data on the number of rare donors registered by year, and the number of requests for rare blood components received and fulfilled over the 25 years of the program (1998-2023) are provided, along with a description of some notable cases and discussion of how the program supports patients with sickle cell disease.
Assuntos
Doadores de Sangue , Humanos , Doadores de Sangue/provisão & distribuição , Doadores de Sangue/estatística & dados numéricos , Estados Unidos , Anemia Falciforme/epidemiologia , Anemia Falciforme/terapia , Anemia Falciforme/sangue , Isoanticorpos/sangue , Isoanticorpos/imunologia , Bancos de Sangue , Antígenos de Grupos Sanguíneos/imunologia , História do Século XXI , Transfusão de SangueRESUMO
This case report showcases an extraordinary collaboration to support the transfusion needs of a patient with a rare phenotype and long-standing anemia due to gastrointestinal bleeding. This report describes the Immunohematology Reference Laboratory testing and logistics of rare blood provision over an 11-year period, as well as a summary of the hematologic, gastroenterologic, and surgical interventions. This case illustrates how a strong collaboration among the clinical team, laboratory, blood center, and the rare donor community facilitated successful management of this patient's anemia until the patient could receive life-changing treatment.