RESUMO
Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purines (15-27), 9-(p-toluenesulfonyl/cyclopentyl/ethoxycarbonylmethyl)-6-(substituted amino/piperazino)purines (28-34, 36, 37, 38-41) were synthesized and evaluated initially for their cytotoxic activities on liver Huh7, breast T47D and colon HCT116 carcinoma cells. N(6)-(4-Trifluoromethylphenyl)piperazine derivative (17) and its 9-(p-toluene-sulfonyl)/9-cyclopentyl analogues (28, 36) had promising cytotoxic activities. Compounds 17, 28 and 36 were further analysed for their cytotoxicity in a panel of a liver cancer cell lines. The compound 36 had better cytotoxic activities (IC50 ≤ 1 µM) than the nucleobase 5-FU and nucleosides fludarabine, cladribine, and pentostatine on Huh7 cells. Cytotoxicity induced by 36 was later identified as senescence associated cell death by SA-ß-Gal assay.
Assuntos
Antineoplásicos/síntese química , Antineoplásicos/farmacologia , Purinas/química , Purinas/farmacologia , Antineoplásicos/química , Morte Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Células HCT116 , Células Hep G2 , Humanos , Modelos Moleculares , Estrutura Molecular , Relação Estrutura-Atividade , Células Tumorais CultivadasRESUMO
In the title compound, C23H22BrNO, the cyclo-heptane ring adopts a chair conformation. The pyridine ring makes dihedral angles of 58.63â (15) and 8.27â (16)° with the benzene rings. The dihedral angle between the benzene rings is 56.68â (17)°. The crystal packing features C-Brâ¯π inter-actions [Brâ¯centroid distances= 3.813â (2) and 3.839â (2)â Å; C-Brâ¯centroid = 126.25â (10) and 138.31â (10)°, respectively, forming a three dimensional supramolecular architecture.
RESUMO
Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, we report the synthesis and the in vitro insulin releasing activity of the 6-methyl-chromonyl-2,4-thiazolidinediones (IIIa-c, IVa-c, Va-c). Compounds IIIb, IIIc, IVa-c, Va and Vc (at lower concentration; 0.001 mg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose. In this series, the most potent compound is IVa having methyl group at N3 position of TZD ring.
Assuntos
Etilenotioureia/química , Etilenotioureia/farmacologia , Hipoglicemiantes/síntese química , Hipoglicemiantes/farmacologia , Imidazolidinas/farmacologia , Tiazolidinedionas/química , Tiazolidinedionas/farmacologia , Animais , Células Cultivadas , Cristalografia por Raios X , Etilenotioureia/síntese química , Hipoglicemiantes/química , Imidazolidinas/síntese química , Imidazolidinas/química , Insulina/metabolismo , Secreção de Insulina , Células Secretoras de Insulina/efeitos dos fármacos , Células Secretoras de Insulina/metabolismo , Modelos Moleculares , Estrutura Molecular , Ratos , Tiazolidinedionas/síntese químicaRESUMO
In the title compound, C(14)H(11)IN(2)O(3)·CH(4)O, the dihedral angle between the benzene rings is 33.2â (3)°. The mol-ecule displays trans and anti conformations about the C=N and N-N bonds, respectively. There is an intra-molecular O-Hâ¯N(azomethine) hydrogen bond. Inter-molecular N-Hâ¯O and O-Hâ¯O hydrogen bonds consolidate mol-ecules into a three-dimensional architecture.
RESUMO
In the title compound, C(15)H(10)FNO(3), the dihedral angle between the isoindoline-1,3-dione and 3-fluoro-4-methyl-phenol groups is 86.88â (8)°. The isoindoline-1,3-dione fragment is almost planar, with an r.m.s. deviation of 0.0154â Å within the group. Inter-molecular C-Hâ¯O hydrogen bonds generate C(6) chains running parallel to the [010] direction.
RESUMO
In the title compound, C(19)H(16)ClNO, the dihedral angle between the naphthalene ring system and the chloro-benzene ring is 61.90â (10)° and the C-N-C-C torsion angle is 174.6â (2)°. The mol-ecular structure is stabilized by an intra-molecular C-Hâ¯N hydrogen bond. The crystal structure features π-π stacking inter-actions [centroid-centroid distances = 3.7325â (17) and 3.8150â (17)â Å].
RESUMO
The title molecule, (E)-3-chloro-N-((5-nitrothiophen-2-yl)methylene)aniline, (C(11)H(7)ClN(2)O(2)S), was synthesized and characterized by IR and single-crystal X-ray structure determination. The compound crystallizes in the monoclinic space group P2(1)/c. In addition, the molecular geometry, vibrational frequencies and frontier molecular orbitals analysis of the title compound in the ground state have been calculated by using the PM3 semi-empirical, HF/6-31G(d) and B3LYP/6-31G(d) ab initio methods. The results of the optimized molecular structure are exhibited and compared with the experimental X-ray diffraction and the calculated results are show that the optimized geometry can well reproduce the crystal structure. The Schiff base compounds are very important in medicinal and pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities such as antimicrobial, antifungal as well as antitumor activity. Therefore, (C(11)H(7)ClN(2)O(2)S) was investigated for their antimicrobial activities, Gram-positive and Gram-negative bacteria.
Assuntos
Compostos de Anilina/farmacologia , Anti-Infecciosos/farmacologia , Tiofenos/farmacologia , Compostos de Anilina/química , Anti-Infecciosos/química , Bactérias/efeitos dos fármacos , Cristalografia por Raios X , Testes de Sensibilidade Microbiana , Conformação Molecular , Termodinâmica , Tiofenos/química , VibraçãoRESUMO
In the title compound, C(11)H(10)Br(2)O(2), the cyclo-pentene ring fused to the benzene ring adopts an envelope conformation, with the C atom attached to the Br atom as the flap. The crystal structure does not exhibit any classical hydrogen bonds. The mol-ecular packing is stabilized by van der Waals forces and π-π stacking inter-actions with a centroid-centroid distance of 3.811â (4)â Å.
RESUMO
The title Schiff base, C(17)H(19)IN(2)O, is not planar, displaying a dihedral angle of 34.9â (2)° between the two aromatic rings. The mol-ecular conformation allows the formation of a strong intra-molecular O-Hâ¯N hydrogen bond with graph-set motif S(6) between the hy-droxy group and the imine N atom.
RESUMO
In the title compound, C(22)H(18)N(4)O(2), the mol-ecules lie across an inversion centre. The dihedral angle between the mean planes of the central and terminal benzene rings is 66.03â (2)°. The mol-ecule displays trans and anti conformations about the C=N and N-N bonds, respectively. In the crystal, N-Hâ¯O hydrogen bonds, with the O atoms of C=O groups acting as acceptors, link the mol-ecules into a chain along [101].
RESUMO
In this study, two new series of 2-amino-1,3,4-oxadiazoles and 5-aryl-1,3,4-oxadiazoles carrying a benzimidazole moiety were synthesized. The antioxidant properties of these compounds were investigated in vitro by the determination of the microsomal NADPH-dependent inhibition of lipid peroxidation levels (LP), the microsomal ethoxyresorufin O-deethylase activity (EROD), and DPPH radical scavenger effects. Among the tested compounds, 2-[(2-(4-chlorophenyl)-1H-benzo[d]imidazole-1-yl)methyl]-5-(4-fluorophenyl)-1,3,4-oxadiazole (9) was found to be the most active compound in all three in vitro systems.
Assuntos
Antioxidantes/síntese química , Benzimidazóis/química , Desenho de Fármacos , Peroxidação de Lipídeos/efeitos dos fármacos , Micro-Ondas , Oxidiazóis/síntese química , Animais , Antioxidantes/química , Antioxidantes/farmacologia , Compostos de Bifenilo/química , Cristalografia por Raios X , Citocromo P-450 CYP1A1/metabolismo , Radicais Livres/metabolismo , Técnicas In Vitro , Masculino , Microssomos Hepáticos/efeitos dos fármacos , Microssomos Hepáticos/enzimologia , Microssomos Hepáticos/metabolismo , Estrutura Molecular , Oxidiazóis/química , Oxidiazóis/farmacologia , Picratos/química , Ratos , Ratos Wistar , Relação Estrutura-AtividadeRESUMO
The title molecule (C19H17N5O4S·H2O) was synthesized and characterized by IR-NMR spectroscopy, MS and single-crystal X-ray diffraction. The molecular geometry, vibrational frequencies and gauge-independent atomic orbital (GIAO) 1H and 13C NMR chemical shift values of the compound in the ground state have been calculated by using the density functional theory (DFT) method with 6-31G(d) basis set, and compared with the experimental data. All the assignments of the theoretical frequencies were performed by potential energy distributions using VEDA 4 program. The calculated results show that the optimized geometries can well reproduce the crystal structural parameters, and the theoretical vibrational frequencies and 1H and 13C NMR chemical shift values show good agreement with experimental data. To determine conformational flexibility, the molecular energy profile of the title compound was obtained with respect to the selected torsion angle, which was varied from -180° to +180° in steps of 10°. Besides, molecular electrostatic potential (MEP), frontier molecular orbitals (FMO) analysis and thermodynamic properties of the compound were investigated by theoretical calculations.
Assuntos
Nitrobenzenos/química , Pirazóis/química , Tioureia/análogos & derivados , Cristalografia por Raios X , Espectroscopia de Ressonância Magnética , Modelos Moleculares , Nitrobenzenos/síntese química , Pirazóis/síntese química , Teoria Quântica , Espectroscopia de Infravermelho com Transformada de Fourier , Tioureia/síntese químicaRESUMO
In the title compound, C(21)H(21)NO, the dihedral angle between the naphthalene ring system and the benzene ring is 64.61â (6)°. The mol-ecular structure is stabilized by an intra-molecular C-Hâ¯N hydrogen bond.
RESUMO
The title compound, C(10)H(14)N(4)O(2)S, exists in the amine tautomeric form. The dihedral angle between the benzene and thia-diazo-lidine rings is 66.54â (19)°. In the crystal, mol-ecules are linked by N-Hâ¯O and N-Hâ¯N hydrogen bonds into a layer parallel to the ac plane. The layers are further linked by C-Hâ¯O hydrogen bonds.
RESUMO
The structure of the title compound, C(15)H(14)N(2)O(2), an azo dye, displays a trans configuration with respect to the N=N bridge. The dihedral angle between the aromatic rings is 5.06â (8)°. The mol-ecular conformation is stabilized by a strong intra-molecular O-Hâ¯O hydrogen bond. In the crystal, inter-molecular C-Hâ¯O hydrogen bonds occur.
RESUMO
In the title compound, C(12)H(10)N(2)O(3), the dihedral angle between the benzene ring and the furan ring is 16.12â (13)°. The conformation is stabilized by an intra-molecular O-Hâ¯N hydrogen bond. Inter-molecular N-Hâ¯O hydrogen bonds with the keto group as acceptor lead to strands along [001]. The mol-ecule displays a trans configuration with respect to the C=N and N-N bonds.
RESUMO
In the title compound, C(16)H(12)N(2)O(3), the dihedral angle between the mean planes of the naphthalene ring system and the furan ring is 21.3â (6)°. The mol-ecular structure is stabilized by an intra-molecular O-Hâ¯N hydrogen bond, which generates an S(6) graph-set motif.
RESUMO
The title compound, C(4)H(5)N(3)O(2), features an essentially planar mol-ecule (r.m.s. deviation for all non-H atoms = 0.013â Å). The crystal structure is stabilized by inter-molecular N-Hâ¯O hydrogen bonds and π-π stacking inter-actions (centroid-centroid distance 3.882â Å).
RESUMO
In the title moleclue, C(19)H(21)NO, the 4-piperidone ring adopts a chair conformation in which the two benzene rings and the methyl group attached to C atoms all have equatorial orientations. In the crystal structure, centrosymmetric dimers are formed through weak inter-molecular C-Hâ¯O hydrogen bonds [the dihedral angle between the aromatic rings is 58.51â (5)°].
RESUMO
In the title compound, [Cu(C(2)H(8)N(2))(2)](C(12)H(6)N(2)O(4)S(2))·1.5H(2)O, there are two half-molecules of the cationic complex in the asymmetric unit. The Cu(2+) ions lie on inversion centres and are octa-hedrally coordinated by two ethyl-enediamine (en) and two aqua ligands in a typical Jahn-Teller distorted environment with the water O atoms in the axial positions. Two 2-mercaptonicotinate units (mnic) are linked by a disulfide bridge. All the ethyl-enediamine N-H and O-H groups form inter-molecular hydrogen bonds with acceptor O and N atoms, giving rise to a three-dimensional network. One of the uncoordinated water molecules has a site occupation factor of 0.5.