RESUMO
Various diseases of the peripheral nervous system are associated with metabolic disorders of B vitamins. A lack of neurotropic vitamins, which began in the early stages of the development of a bacterial disease, led to its more rapid development. The article analyzes data on B vitamin deficiency in the pathogenesis of the most dangerous diseases of the peripheral nervous system. Information is provided about the dangers of the clinical use of the drug Combilipen for the treatment of such patients.
Assuntos
Doenças do Sistema Nervoso Periférico , Complexo Vitamínico B , Humanos , Complexo Vitamínico B/uso terapêutico , Deficiência de Vitaminas do Complexo B/complicações , Deficiência de Vitaminas do Complexo B/tratamento farmacológicoRESUMO
Presented herein are long-term outcomes of surgical treatment of 74 patients with atherosclerotic occlusive-stenotic lesions of the femoral-popliteal-tibial segment and critical ischaemia. 51 (68.92%) patients underwent femoropopliteal shunting into the isolated segment of the reversed great saphenous vein. Of these, three patients were subjected to a hybrid operation consisting of femoropopliteal bypass grafting and balloon angioplasty of the popliteal and one tibial artery. 23 (31.08%) patients endured percutaneous balloon angioplasty with stenting of the superficial femoral artery and balloon angioplasty of one tibial artery. Two-year patency of the zone of reconstruction of the femoropopliteal segment in these groups was identical, amounting to 64.71 and 56.52%, respectively. However, the group of patients with endovascular intervention demonstrated rather a high rate of intraoperative complications--21.74%, technical success in balloon angioplasty of arteries of the crus amounted to 65.22%. Once the method of operative treatment is chosen, preference is given to shunting in the isolated popliteal artery with sufficient collateral blood flow. Further studies are required to determine angiographic indications for endovascular intervention on tibial arteries.
Assuntos
Angioplastia com Balão , Arteriopatias Oclusivas , Cuidados Intraoperatórios/métodos , Complicações Intraoperatórias , Extremidade Inferior/irrigação sanguínea , Artéria Poplítea/cirurgia , Enxerto Vascular , Idoso , Angioplastia com Balão/efeitos adversos , Angioplastia com Balão/instrumentação , Angioplastia com Balão/métodos , Arteriopatias Oclusivas/diagnóstico , Arteriopatias Oclusivas/fisiopatologia , Arteriopatias Oclusivas/cirurgia , Pesquisa Comparativa da Efetividade , Feminino , Artéria Femoral/cirurgia , Humanos , Complicações Intraoperatórias/etiologia , Complicações Intraoperatórias/prevenção & controle , Isquemia/fisiopatologia , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Stents , Artérias da Tíbia/cirurgia , Resultado do Tratamento , Enxerto Vascular/efeitos adversos , Enxerto Vascular/métodos , Grau de Desobstrução VascularRESUMO
The results of experimental studies and clinical trials of alpha-lipoic acid drugs are presented. Antioxidant and neuroprotective effects provide the efficacy of these drugs in patients with different diseases of the central and peripheral nervous systems. Good tolerability and possibilities of using in combinations with other drugs give grounds for a wide application of the drug in neurological practice.