A novel deep learning model for breast lesion classification using ultrasound Images: A multicenter data evaluation.

PURPOSE: Breast cancer is one of the major reasons of death due to cancer in women. Early diagnosis is the most critical key for disease screening, control, and reducing mortality. A robust diagnosis relies on the correct classification of breast lesions. While breast biopsy is referred to as the "gold standard" in assessing both the activity and degree of breast cancer, it is an invasive and time-consuming approach. METHOD: The current study's primary objective was to develop a novel deep-learning architecture based on the InceptionV3 network to classify ultrasound breast lesions. The main promotions of the proposed architecture were converting the InceptionV3 modules to residual inception ones, increasing their number, and altering the hyperparameters. In addition, we used a combination of five datasets (three public datasets and two prepared from different imaging centers) for training and evaluating the model. RESULTS: The dataset was split into the train (80%) and test (20%) groups. The model achieved 0.83, 0.77, 0.8, 0.81, 0.81, 0.18, and 0.77 for the precision, recall, F1 score, accuracy, AUC, Root Mean Squared Error, and Cronbach's α in the test group, respectively. CONCLUSIONS: This study illustrates that the improved InceptionV3 can robustly classify breast tumors, potentially reducing the need for biopsy in many cases.

Clinical target segmentation using a novel deep neural network: double attention Res-U-Net.

We introduced Double Attention Res-U-Net architecture to address medical image segmentation problem in different medical imaging system. Accurate medical image segmentation suffers from some challenges including, difficulty of different interest object modeling, presence of noise, and signal dropout throughout the measurement. The base line image segmentation approaches are not sufficient for complex target segmentation throughout the various medical image types. To overcome the issues, a novel U-Net-based model proposed that consists of two consecutive networks with five and four encoding and decoding levels respectively. In each of networks, there are four residual blocks between the encoder-decoder path and skip connections that help the networks to tackle the vanishing gradient problem, followed by the multi-scale attention gates to generate richer contextual information. To evaluate our architecture, we investigated three distinct data-sets, (i.e., CVC-ClinicDB dataset, Multi-site MRI dataset, and a collected ultrasound dataset). The proposed algorithm achieved Dice and Jaccard coefficients of 95.79%, 91.62%, respectively for CRL, and 93.84% and 89.08% for fetal foot segmentation. Moreover, the proposed model outperformed the state-of-the-art U-Net based model on the external CVC-ClinicDB, and multi-site MRI datasets with Dice and Jaccard coefficients of 83%, 75.31% for CVC-ClinicDB, and 92.07% and 87.14% for multi-site MRI dataset, respectively.