Morbidity after local excision of the transformation zone for cervical intra-epithelial neoplasia and early cervical cancer.

The awareness that cervical intra-epithelial neoplasia (CIN) treatment increases the risk of preterm birth has led to major changes in clinical practice. Women with CIN have a higher baseline risk of prematurity but local treatment further increases this risk. The risk further increases with increasing cone length and multiplies for repeat excisions; it is unclear whether small cones confer any additional risk to CIN alone. There is no evidence to suggest that fertility is affected by local treatment, although this increases the risk of mid-trimester loss. Caution should prevail when deciding to treat women with CIN of reproductive age. If treatment is offered, this should be conducted effectively to optimise the clearance of disease and minimise the risk of recurrence. Colposcopists should alert women undergoing treatment that this may increase the risk of preterm birth and that they may be offered interventions when pregnant. The cone length should be clearly documented and used as a risk stratifier.

Bisphenol A in Dentistry.

Bisphenol-A, an organic synthetic compound, has been present in many consumer plastic products and food packaging since the 1960s. Nowadays, Bisphenol-A is widely used in the field of dentistry for the manufacturing of resin materials. Several studies have suggested that Bisphenol-A may cause adverse health effects due to its ability to act as an endocrine disruptor chemical which has raised concerns about its widespread use. The aim of this study is to present an overview of the research studies dealing with Bisphenol-A exposure in the field of dentistry. PubMed, Scopus, EMBASE, Europe PMC, Web of Science and reference lists of relevant papers were searched to identify articles for inclusion. Two authors screened literature and extracted data from included studies independently. The evidence supports that Bisphenol A is used in many fields of routine clinical dental practice such as restorative dentistry and orthodontics. Regarding Bisphenol-A exposure from dental materials, the current data concludes that is below the Tolerable Daily Intake levels, but further evaluation is needed to reveal any possible adverse events caused by low-dose BPA exposure.