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1.
Interv Neuroradiol ; : 15910199241286753, 2024 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-39327944

RESUMO

BACKGROUND: Many devices are used to perform mechanical thrombectomy in the setting of large vessel occlusion acute ischemic stroke. We sought to evaluate the efficacy and safety of pRESET stent-retriever systems. METHODS: We conducted a comprehensive systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant studies up to March 2024 were retrieved from PubMed, Scopus, Web of Science, and Embase databases. RESULTS: A total of 8 papers met the inclusion/exclusion criteria comprising a total of 1140 participants (average age 72.4 ± 11.9, female percentage (50%). Preintervention intravenous thrombolysis was utilized in 46.5% (range 32.9-65.4) of patients, with a median National Institute of Health Stroke Scale at presentation of 15 (range 0-38). The middle cerebral artery was the most commonly affected artery, with a prevalence of 76.4% (range 62.8-100). The pRESET stent-retriever systems demonstrated a first-passing effect rate of 53.4% [95% confidence interval [CI] 44.8; 61.7] and a final thrombolysis in cerebral infarction 2b-3 grade rate of 90.41% [95% CI 82.13; 95.08]. Ninety-day modified Rankin Scale (0-2) rate was 42.2% [95% CI 27.6; 58.4], and 90-day mortality rate was 15.1% [95% CI 9.8; 22.6]. Postintervention hemorrhage occurred at a rate of 28.6% [CI 17.2; 43.6]. CONCLUSION: Our systematic review and meta-analysis describes the efficacy of the pRESET stent retriever system in managing acute ischemic stroke patients. The pRESET device was found to have a similar safety and efficacy profile to other mechanical thrombectomy devices currently in use.

2.
Dev Med Child Neurol ; 2024 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-39279261

RESUMO

AIM: To address substantial gaps in the literature on neuroanatomical variations in females with fragile X syndrome (FXS). METHOD: Surface-based modeling techniques were applied to the magnetic resonance imaging of 45 females with FXS (mean age = 10 years 9 months, range 6 years-16 years 4 months, SD = 2 years 9 months) and 33 age-matched and developmentally matched females without FXS to elucidate differences in cortical gray matter volume, surface area, and thickness. Gray matter volumes in subcortical regions were examined to ascertain differences in subcortical volume. RESULTS: In females with FXS, cortical volume was greater bilaterally in the occipital pole and smaller in the right postcentral gyrus. Seven regions demonstrated lower surface area in participants with FXS, while cortical thickness was significantly greater over the posterior and medial surfaces in the group with FXS. Subcortical region of interest analyses demonstrated greater volume in the caudate nucleus, globus pallidus, and nucleus accumbens in the group with FXS. Global gray matter volume, pial thickness, and surface area were associated with behavioral outcomes in the group with FXS but not in the comparison group. INTERPRETATION: Females with FXS demonstrated unique cortical and subcortical gray matter anatomy relative to a matched comparison group. These findings may be relevant to the pathogenesis of the FXS behavioral phenotype and provide insights into behavioral interventions targeted to this population.

3.
S D Med ; 77(4): 147-148, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38991157
4.
Transl Stroke Res ; 2024 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-38831158

RESUMO

Since 2007, research groups are mandated by the Food and Drug Administration Amendments Act (FDAAA) to report clinical trial findings to ClinicalTrials.gov within 12 months of trial completion. This observational study aims to analyze compliance data of stroke-related randomized controlled trials subject to these mandates. Using a previously published algorithm, we identified clinical trials likely to be required to adhere to FDAAA mandates (highly likely applicable clinical trials, or HLACTs) from January 2008 to February 2023. We assessed the proportion of studies that reported results within 12 months of trial completion, as well as those that reported at any point within 5 years. Additionally, we utilized Kaplan-Meier and regression analysis to explore factors associated with on-time reporting. Among 357 stroke-related HLACTs on ClinicalTrials.gov that were terminated or completed between January 1, 2008, and February 1, 2023, 59 (16.5%) reported results within 12 months, while 320 (89.6%) reported results within 5 years. Median reporting times for industry funded, other government or academic institution funded, and National Institute of Health (NIH) funded studies were 18.5 months, 22 months, and 22.5 months, respectively. Open-label studies were less likely to report results by 12 months compared to double-blinded studies (p = 0.002). Biological trials exhibited a lower probability of reporting within 5 years compared to device and/or drug trials (p = 0.007). Clinical trial registries and FDAAA mandates aim to promote accountability and transparency in health sciences research. However, regardless of their funding source, only a minority of stroke-related randomized controlled trials comply with FDAAA's 12-month result reporting mandate.

6.
Occup Med (Lond) ; 59(1): 44-52, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19073992

RESUMO

BACKGROUND: Upper limb disorders (ULDs) are clinically challenging and responsible for considerable work loss. There is a need to determine effective approaches for their management. AIM: To determine evidence-based management strategies for work-relevant ULDs and explore whether a biopsychosocial approach is appropriate. METHODS: Literature review using a best evidence synthesis. Data from articles identified through systematic searching of electronic databases and citation tracking were extracted into evidence tables. The information was synthesized into high-level evidence statements, which were ordered into themes covering classification/diagnosis, epidemiology, associations/risks and management/treatment, focusing on return to work or work retention and taking account of distinctions between non-specific complaints and specific diagnoses. RESULTS: Neither biomedical treatment nor ergonomic workplace interventions alone offer an optimal solution; rather, multimodal interventions show considerable promise, particularly for occupational outcomes. Early return to work, or work retention, is an important goal for most cases and may be facilitated, where necessary, by transitional work arrangements. The emergent evidence indicates that successful management strategies require all the players to be on side and acting in a coordinated fashion; this requires engaging employers and workers to participate. CONCLUSIONS: The biopsychosocial model applies: biological considerations should not be ignored, but psychosocial factors are more influential for occupational outcomes. Implementation of interventions that address the full range of psychosocial issues will require a cultural shift in the way the relationship between upper limb complaints and work is conceived and handled. Dissemination of evidence-based messages can contribute to the needed cultural shift.


Assuntos
Doenças Musculoesqueléticas/terapia , Doenças Profissionais/terapia , Extremidade Superior , Transtornos Traumáticos Cumulativos/etiologia , Transtornos Traumáticos Cumulativos/psicologia , Transtornos Traumáticos Cumulativos/terapia , Medicina Baseada em Evidências , Humanos , Doenças Musculoesqueléticas/etiologia , Doenças Musculoesqueléticas/psicologia , Doenças Profissionais/etiologia , Doenças Profissionais/psicologia
7.
J Public Health (Oxf) ; 27(3): 270-5, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16000341

RESUMO

BACKGROUND: As part of the work of the Shipman Inquiry, five general practitioners (GPs) in West Sussex were identified as having excessively high mortality rates. The aim of this study was to identify reasons for the higher-than-expected mortality rates of these five GPs. METHODS: A retrospective analysis was made of routine mortality and patient registration data from primary-care practices in West Sussex, and the case notes of deceased patients were reviewed. Outcome measures included standardized mortality ratios (SMRs), proportion of deaths in nursing homes, and reviewers' concordance with GP decisions to issue a death certificate. RESULTS: The high death rates were not explained by the age and sex composition of each GP's patient population. SMRs ranged from 145 to 239 (average for West Sussex = 100) and all differences from the West Sussex average were statistically significant (p <0.02). SMRs were highly correlated with the proportion of deaths occurring in nursing homes (Pearson's correlation coefficient = 0.95, p = 0.015). Analysis of 153 deceased patients' notes revealed no evidence of poor clinical practice. In 114 cases, at least one independent reviewer agreed with the decision to issue a death certificate. In the remaining 39 (25 per cent) cases, inadequate information in the patient's record explained the reviewers' uncertainty about issuing a certificate. CONCLUSION: A proportionately high registration of nursing home residents is the most likely explanation for the excessive mortality rates of these five GPs. This investigation was time-consuming and costly, and highlights the potential ramifications for primary-care organizations of introducing a national system for monitoring death rates in primary care.


Assuntos
Medicina de Família e Comunidade/normas , Auditoria Médica , Mortalidade , Revisão dos Cuidados de Saúde por Pares , Atenção Primária à Saúde/normas , Gestão de Riscos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Causas de Morte , Criança , Pré-Escolar , Atestado de Óbito , Inglaterra/epidemiologia , Medicina de Família e Comunidade/estatística & dados numéricos , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Auditoria Médica/métodos , Pessoa de Meia-Idade , Casas de Saúde/estatística & dados numéricos , Revisão dos Cuidados de Saúde por Pares/métodos , Atenção Primária à Saúde/estatística & dados numéricos , Estudos Retrospectivos , Gestão de Riscos/métodos
9.
J Med Libr Assoc ; 90(2): 223-9, 2002 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11999181

RESUMO

OBJECTIVES: The objective is to study how the staff who purchase health care services for a large national government accident-compensation system seek information on treatment effectiveness, how they assess the quality of that information, whether they question the information sources they choose, and how familiar they are with the key concepts of evidence-based health care (EBHC). METHOD: Staff (22 out of 34) of the health purchasing division of the New Zealand Accident Compensation Corporation (NZ ACC) were interviewed using eight preformatted questions to which they could provide open and multiple answers. Responses were subsequently codified into typologies for quantitative analysis. RESULTS: Most respondents report that they assess the effectiveness of a treatment by accessing published information (nonhuman sources), by consulting others (human sources), or by both means. They assess the quality of information mostly by consulting others, and the second-highest proportion of responses state that they do not know how to evaluate the quality of information. No clear preference emerges with respect to the types of information needed to determine the effectiveness of treatments. The majority of the staff believes they can access information needed to determine treatment effectiveness through the Internet or information databases such as MEDLINE. Although most said they understand the key concepts of EBHC, only five out of twenty-two were able to accurately describe them. CONCLUSIONS: The findings suggest that there is a low level of awareness among the staff of the NZ ACC regarding the use of evidence and understanding of the key concepts of EBHC. Many surveyed staff members lack the skills or training to directly question information about effectiveness of a treatment. They have little idea of the information required to determine the effectiveness of a treatment, and the majority appears to lack the skills to evaluate the health care literature.


Assuntos
Pesquisa sobre Serviços de Saúde/organização & administração , Serviços de Informação/normas , Seguro de Acidentes , Resultado do Tratamento , Adulto , Conscientização , Tomada de Decisões , Feminino , Humanos , Serviços de Informação/estatística & dados numéricos , Benefícios do Seguro/normas , Cobertura do Seguro/normas , Masculino , Pessoa de Meia-Idade , Nova Zelândia , Objetivos Organizacionais , Garantia da Qualidade dos Cuidados de Saúde/métodos
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