Risk factors associated with elevated intraocular pressure: a population-based study in a rural community of Bangladesh.

OBJECTIVE: High intraocular pressure (IOP) is one of the major modifiable risk factors for glaucoma. The objective was to examine socio-demographic and clinical factors related to IOP. METHODS AND ANALYSIS: This study was conducted among 3097 adults residing in a rural area of Bangladesh, with all participants undergoing clinical and ophthalmological evaluations. The measurement of IOP was carried out using of a rebound Tonometer called Icare pro. Multiple logistic regression analysis was employed to identify variables associated to IOP levels of 21 mm Hg or above. Adjusted OR (aOR) and 95% CI were reported. RESULTS: This study found that, in total, 9% of the study population had high IOP in one or both eyes. Elevated IOP was significantly associated with respondents who were service holders (aOR 2.52; 95% CI 1.48 to 4.31), had a lower education level (aOR 1.55, 95% CI 1.07 to 2.23), used biomass fuel (aOR 2.00; 95% CI 1.09 to 3.67), belonged to a higher socioeconomic position (aOR 1.55, 95% CI 1.07 to 2.23) and had obesity (aOR 2.00; 95% CI 1.07 to 3.73), hypertension (aOR 1.32; 95% CI 1.01 to 1.73) or history of diabetes (aOR 2.44; 95% CI 1.67 to 3.55), after adjusting for covariates including age, sex, marital status, light source and tobacco consumption, in a multiple regression analysis. CONCLUSION: Chronic diseases, such as hypertension and diabetes, obesity and sociodemographic characteristics such as high socioeconomic status and use of biomass fuels, have all been linked to elevated IOP. Patients with chronic diseases should undergo for IOP testing regularly.

Perceived Parental Undifferentiated Rejection and Children's Personality Dispositions: A Meta-Analysis of Multicultural Studies.

Prior multicultural meta-analyses have shown that three of the four individual expressions of parental rejection (viz., coldness/lack of affection, hostility/aggression, and indifference/neglect) tend to be significantly associated with all seven of the personality dispositions most central to interpersonal acceptance-rejection theory (IPARTheory). These dispositions include hostility/aggression, dependence, negative self-esteem, negative self-adequacy, emotional instability, emotional unresponsiveness, and negative worldview. However, it was unknown whether the fourth expression of rejection (i.e. undifferentiated rejection) tends to be associated transculturally, as predicted by the theory, with this cluster of dispositions among children. Thus, this meta-analysis investigated 1) the extent to which children's perceptions of maternal and paternal undifferentiated rejection were related to these personality dispositions, and 2) the extent to which these relations varied by gender of parent. To address these questions, we performed a meta-analysis on 16 studies involving 12,538 children in 14 countries. Results showed significant associations between all seven personality dispositions and both maternal and paternal undifferentiated rejection. The results also showed significantly stronger relations between maternal than paternal undifferentiated rejection on five of the seven indices of children's personality.

Genomic landscape of prominent XDR Acinetobacter clonal complexes from Dhaka, Bangladesh.

BACKGROUND: Acinetobacter calcoaceticus-A. baumannii (ACB) complex pathogens are known for their prevalence in nosocomial infections and extensive antimicrobial resistance (AMR) capabilities. While genomic studies worldwide have elucidated the genetic context of antibiotic resistance in major international clones (ICs) of clinical Acinetobacter spp., not much information is available from Bangladesh. In this study, we analysed the AMR profiles of 63 ACB complex strains collected from Dhaka, Bangladesh. Following this, we generated draft genomes of 15 of these strains to understand the prevalence and genomic environments of AMR, virulence and mobilization associated genes in different Acinetobacter clones. RESULTS: Around 84% (n = 53) of the strains were extensively drug resistant (XDR) with two showing pan-drug resistance. Draft genomes generated for 15 strains confirmed 14 to be A. baumannii while one was A. nosocomialis. Most A. baumannii genomes fell under three clonal complexes (CCs): the globally dominant CC1 and CC2, and CC10; one strain had a novel sequence type (ST). AMR phenotype-genotype agreement was observed and the genomes contained various beta-lactamase genes including blaOXA-23 (n = 12), blaOXA-66 (n = 6), and blaNDM-1 (n = 3). All genomes displayed roughly similar virulomes, however some virulence genes such as the Acinetobactin bauA and the type IV pilus gene pilA displayed high genetic variability. CC2 strains carried highest levels of plasmidic gene content and possessed conjugative elements carrying AMR genes, virulence factors and insertion sequences. CONCLUSION: This study presents the first comparative genomic analysis of XDR clinical Acinetobacter spp. from Bangladesh. It highlights the prevalence of different classes of beta-lactamases, mobilome-derived heterogeneity in genetic architecture and virulence gene variability in prominent Acinetobacter clonal complexes in the country. The findings of this study would be valuable in understanding the genomic epidemiology of A. baumannii clones and their association with closely related pathogenic species like A. nosocomialis in Bangladesh.

Recent Advanced in MXene Research toward Biosensor Development.

MXene is a rapidly emerging group of two-dimensional (2D) multifunctional nanomaterials, drawing huge attention from researchers of a broad scientific field. Reporting the synthesis of MXene was the following breakthrough in 2D materials following the discovery of graphene. MXene is considered the most recent developments of materials, including transition metal carbonitrides, nitrides, and carbides synthesized by etching or mechanical-based exfoliation of selective MAX phases. MXene has a plethora of prodigious properties such as unique interlayer spacing, high ion and electron transport, large surface area, excellent thermal and electrical conductivity, exceptional volumetric capacitance, thermal shock, and oxidation resistance, easily machinable and inherently hydrophilic, and biocompatibility. Owing to the abundance of tailorable surface function groups, these properties can be further enhanced by surface functionalization with covalent and non-covalent modifications via numerous surface functionalization methods. Therefore, MXene finds their way to a plethora of applications in numerous fields including catalysis, membrane separation, energy storage, sensing, and biomedicine. Here, the focus is on reviewing the structure, synthesis techniques, and functionalization methods of MXene. Furthermore, MXene-based detection platforms in different sensing applications are survived. Great attention is given to reviewing the applications of MXene in the detection of biomolecules, pathogenic bacteria and viruses, cancer biomarkers food contaminants and mycotoxins, and hazardous pollutants. Lastly, the future perspective of MXene-based biosensors as a next-generation diagnostics tool is discussed. Crucial visions are introduced for materials science and sensing communities to better route while investigating the potential of MXene for creating innovative detection mechanisms.

Hysteresis and return point memory in the random-field Blume-Capel model.

We study the zero-temperature steady-state of the random-field Blume-Capel model with spin-flip Glauber dynamics on a random regular graph. The magnetization m as a function of the external field H is observed to have double hysteresis loops with a return point memory. We also solve the model on a Bethe lattice in the approximation that the spin relaxation dynamics is abelian and find good agreement between simulations on random regular graphs and Bethe lattice calculations for negative values of H.

Outcome and complications of pediatric acute promyelocytic leukemia in Bangladesh.

Pediatric acute promyelocytic leukemia (APL) is one of the most curable subtypes of acute myeloid leukemia of childhood. But it may have many early complications, especially in developing countries. This study aims to describe the outcome and complications of pediatric APL patients in Bangladesh. This prospective observational study was conducted in the pediatric hematology and oncology department of Bangabandhu Sheikh Mujib Medical University, Dhaka from September 2017 to March 2019. In this study, PML:RAR-α (Promyelocytic leukemia-retinoic acid receptor-α) positive APL cases were included and observed while being treated with risk-directed ATRA (All-trans-retinoic acid) based chemotherapy. Among twenty PML:RAR-α positive APL cases, 13 children were in the high risk group and hemorrhagic manifestations were present in 95% of patients. Post-induction remission was achieved in 85% of the patients. 3-year overall survival was 70% (45-85% with 95% confidence interval). There was no refractory disease or relapses. Neutropenic sepsis was the most common complication and also the most common cause of mortality. In Bangladesh, the 3-year overall survival of pediatric APL is 70% (45-85% with 95% CI). Post-chemotherapy neutropenic sepsis is the most common complication and also the most common cause of mortality in this potentially curable malignancy in Bangladesh.

Low-loss single-mode modified conjoined tube hollow-core fiber.

We explain the effects of cladding geometries on conjoined tube hollow-core negative curvature fibers and offer a modified conjoined tube negative curvature fiber with appropriate positioning of an additional negative curvature D-shaped layer joining the flat bar to reveal attractive performances over existing recent related fibers. The proposed fiber ensures the least loss of 0.003 dB/km at 1.43 µm, a ∼0.04dB/km loss covering the wide bandwidth of approximately 300 nm, the lowest surface scattering loss of ∼0.02dB/km, and the lowest microbending loss of ∼0.04dB/km, thus providing a propagation loss of 0.10 dB/km at the 1.55 µm wavelength and also offering excellent bend loss performance (∼0.015dB/km loss at a 7 cm bend radius). The fiber, with a core diameter of 30.50 µm, also shows a higher-order mode extinction ratio of ∼1600 and maintains greater than 100 over most of the telecom bands; hence, it effectively provides single-mode operation. We show the potential of conjoined tube hollow-core negative curvature fibers in optical communications systems.

Genotype-phenotype correlation of ß-lactamase-producing uropathogenic Escherichia coli (UPEC) strains from Bangladesh.

Escherichia coli is a pathogen commonly encountered in clinical laboratories, and is capable of causing a variety of diseases, both within the intestinal tract (intestinal pathogenic strains) and outside (extraintestinal pathogenic E. coli, or ExPEC). It is associated with urinary tract infections (UTIs), one of the most common infectious diseases in the world. This report represents the first comparative analysis of the draft genome sequences of 11 uropathogenic E. coli (UPEC) strains isolated from two tertiary hospitals located in Dhaka and Sylhet, Bangladesh, and is focused on comparing their genomic characteristics to each other and to other available UPEC strains. Multilocus sequence typing (MLST) confirmed the strains belong to ST59, ST131, ST219, ST361, ST410, ST448 and ST4204, with one of the isolates classified as a previously undocumented ST. De novo identification of the antibiotic resistance genes blaNDM-5, blaNDM-7, blaCTX-M-15 and blaOXA-1 was determined, and phenotypic-genotypic analysis of virulence revealed significant heterogeneity within UPEC phylogroups.

Ultra-short polarization splitter based on a plasmonic dual-core photonic crystal fiber with an ultra-broad bandwidth.

A compact polarization beam splitter based on a gold-filled photonic crystal fiber with a square lattice is proposed. The full vector finite element method is used to design and characterize the proposed ultra-compact and ultra-broadband polarization splitter. The plasmonic plays an important role in order to achieve an ultra-short length of 56.33 µm with a high extinction ratio of 132.92 dB at the wavelength of 1.55 µm. It can ensure an ultra-broad bandwidth of 530 nm, from 1225 to 1755 nm, covering all the communication bands with an extinction ratio better than 20 dB. The proposed polarization splitter may be a promising candidate in communication due to its ultra-short length and ultra-broad bandwidth.

Molecular analysis of hemagglutinin, neuraminidase, matrix genes provide insight into the genetic diversity of seasonal H3N2 human influenza a viruses in Bangladesh during July-August, 2012.

Influenza A virus subtype H3 is a threat to public health and it is important to understand the evolution of the viruses for the surveillance and the selection of vaccine strains. Comparative analysis of four Bangladeshi isolates with isolates circulating other parts of the world based on three candidate genes hemagglutinin (HA), neuraminidase (NA), matrix protein (MA) showed no evidence of significant distinct subclade of viruses circulating in the country over the period of study. Despite these findings, we found N161S substitution in all four H3N2 influenza stains resulting in the gain of NSS160-162 glycosylation site. All H3N2 Influenza subtypes in the study had amino acid substitution at position 31 on the M2 protein (Aspartic acid to Asparagine) which is known to be responsible for amantadine drug resistance.

Virulence-Related Genes Identified from the Genome Sequence of the Non-O1/Non-O139 Vibrio cholerae Strain VcN1, Isolated from Dhaka, Bangladesh.

We report here the first draft genome sequence of the non-O1/non-O139 Vibrio cholerae strain VcN1, isolated from Dhaka, Bangladesh. The data submitted to GenBank for this strain will contribute to advancing our understanding of this environmentally disseminated bacterium, including its virulence and its evolution as an important pathogen.

Integration of bow-tie plasmonic nano-antennas on tapered fibers.

In this article, a new and flexible approach to control the electric field enhancement of bow-tie nano-antennas by integrating them on the lateral of a tapered optical fiber is proposed. The device is driven by a Q-switched laser and the performance of a fabricated nano-antenna in a quartz slide is tested by a Surface Enhanced Raman Scattering (SERS) experiment. A refractive index sensing experiment is also performed and a sensitivity of (240 ± 30) nm/RIU is found in the 1.33-1.35 index range.

An empirical analysis of the Ebola outbreak in West Africa.

The data for the Ebola outbreak that occurred in 2014-2016 in three countries of West Africa are analysed within a common framework. The analysis is made using the results of an agent based Susceptible-Infected-Removed (SIR) model on a Euclidean network, where nodes at a distance l are connected with probability P(l) ∝ l-δ, δ determining the range of the interaction, in addition to nearest neighbors. The cumulative (total) density of infected population here has the form , where the parameters depend on δ and the infection probability q. This form is seen to fit well with the data. Using the best fitting parameters, the time at which the peak is reached is estimated and is shown to be consistent with the data. We also show that in the Euclidean model, one can choose δ and q values which reproduce the data for the three countries qualitatively. These choices are correlated with population density, control schemes and other factors. Comparing the real data and the results from the model one can also estimate the size of the actual population susceptible to the disease. Rescaling the real data a reasonably good quantitative agreement with the simulation results is obtained.

Ytterbium-doped Q-switched fiber laser based upon manganese dioxide (MnO2) saturable absorber.

Manganese dioxide (MnO2) is an abundant material that is widely used in many devices, such as alkaline batteries. At infrared frequencies, MnO2 is lossy and strongly absorbs light. These characteristics make MnO2 a potential candidate as a low-cost saturable absorber in Q-switched lasers. In this paper, we examine the performance of MnO2 as a saturable absorber in an ytterbium-doped Q-switched fiber laser: we show that it can produce pulses with durations ranging from 300 to 1800 ns.

Absorption enhancement in graphene photonic crystal structures.

Graphene, a single layer of carbon atoms arranged in a honeycomb lattice, is attracting significant interest because of its potential applications in electronic and optoelectronic devices. Although graphene exhibits almost uniform absorption within a large wavelength range, its interaction with light is weak. In this paper, the enhancement of the optical absorption in graphene photonic crystal structures is studied: the structure is modified by introducing scatterers and mirrors. It is shown that the absorption of the graphene photonic crystal structure can be enhanced about four times (nearly 40%) with respect to initial reference absorption of 9.8%. The study can be a useful tool for investigating graphene physics in different optical settings.

Condensation transition in a conserved generalized interacting zero-range process.

A conserved generalized zero-range process is considered in which two sites interact such that particles hop from the more populated site to the other with a probability p. The steady-state particle distribution function P(n) is obtained using both analytical and numerical methods. The system goes through several phases as p is varied. In particular, a condensate phase appears for p_{l}0.5; a scale emerges in the system in the latter and this feature is present for all ranges of interaction.

Finite-difference time-domain methods to analyze ytterbium-doped Q-switched fiber lasers.

Q-switched lasers are widely used in material processing, laser ranging, medicine, and nonlinear optics--in particular, Q-switched lasers in optical fibers are important since they cannot only generate high peak powers but can also concentrate high peak powers in small areas. In this paper, we present new finite-difference time-domain methods that analyze the dynamics of Q-switched fiber lasers, which are more flexible and robust than previous methods. We extend the method to analyze fiber ring lasers and compare the results with our experiments.

Polarizer based upon a plasmonic resonant thin layer on a squeezed photonic crystal fiber.

In this article, a polarizer based on surface plasmon resonance in a squeezed rectangular lattice is analyzed through a full-vector finite-element method solver. The device allows one state of polarization (e.g., y-polarized mode) to propagate through the fiber while the other state (x-polarized mode) is heavily attenuated: the modal losses for the x- and y-polarized modes are 1221 dB/cm and 1.6 dB/cm, respectively, at the wavelength of 1310 nm. Given the high differential attenuation between the two orthogonal polarization modes, the device could be used as a compact polarizer with potential applications in sensing, communications, and other areas.

Thick multilayered (silica/gold) dipole nano-antenna.

Nano-antennas are the optical equivalent of antennas that are used to transmit and receive information at radio frequencies. These antennas have been used in different applications in photonics such as optical imaging, particle manipulation, bio-sensing, and improvement of the performance of solar cells. In this article we study composite nano-antennas made of alternating layers of silica and gold. We show that a 50% filling factor leads to a 2.0 times increase in the electric-field enhancement factor when compared with a pure-gold antenna.

Composite chromium and graphene oxide as saturable absorber in ytterbium-doped Q-switched fiber lasers.

In recent years, graphene and its compounds (e.g., oxides) have been used as saturable absorbers in passive Q-switched and mode-locked lasers, leading to the fabrication of compact pulsed fiber lasers. In this article, we study the operation of a Q-switched ytterbium-doped fiber ring laser based on a composite saturable absorber made of graphene oxide and chromium. We show that the addition of a thin layer of chromium can lead to pulse durations ranging from 3.5 to 9.4 µs and subsequently increasing the laser peak power.