Cocaine-mediated impact on HIV infection in humanized BLT mice.

Cocaine abuse has been shown to have broad-ranging effects on human immunity. With regards to HIV infection, in vitro studies have shown that cocaine enhances infection of stimulated lymphocytes. Moreover, cohort studies in the pre- and post-HAART era have linked stimulant abuse with increased HIV pathogenesis. The latter data, however, have been undermined by a series of confounding factors underscoring the importance of controlled in vivo models to fully assess the impact of cocaine use and abuse on HIV infection and pathogenesis. Here, we have infected humanized mice with HIV-1 following acute cocaine exposure to assess the impact on infection. Stimulant exposure resulted in increased inflammatory cytokine expression, accelerated HIV infection, while blunting effector function of cytotoxic T lymphocytes. These data demonstrate cocaine's multifactorial impact on HIV infection that extends beyond high-risk behavior.

Ethnic and cultural variations in anger regulation and attachment patterns among Korean American and European American male batterers.

This study examined relationships among ethnicity, self-construals, and 2 risk factors for marital violence (anger, insecure attachment) in Korean American and European American male batterers. Korean (vs. European) American batterers experienced more anger and controlled their anger less. Independent self-construal was positively associated with anger experience and anger control and mediated the influence of ethnicity on anger control. Korean batterers were less independent, and less independent batterers controlled their anger less. Korean batterers' attachment styles were more avoidant and less anxious. Independent and interdependent self-construals were negatively associated with anxious and avoidant attachment, respectively. Independent self-construal mediated the influence of ethnicity on avoidant attachment. Clinical severity and adherence to traditional gender roles may help explain these ethnic and cultural variations.

Parenting behaviors and the occurrence and co-occurrence of depressive symptoms and conduct problems among african american children.

The occurrence and co-occurrence of depressive symptoms and conduct problems were examined in the context of parenting behaviors in a community-based sample of 897 African American children and their primary caregivers using a multi-informant, longitudinal design. Parenting behaviors and clinical symptoms were assessed in 2 waves, when the children averaged 10.5 and 12.3 years of age. Parenting behaviors differed significantly according to a child's symptomatology; (a) that is, when a child exhibited no depressive or conduct problems, (b) depressive problems only, (c) conduct problems only, or (d) co-occurring depressive and conduct problems. When parenting behaviors were examined according to changes in children's symptom levels, children whose symptoms increased over time reported increases in hostility and harsh-inconsistent parenting and decreases in warmth and nurturant-involved parenting.

It's about timing and change: pubertal transition effects on symptoms of major depression among African American youths.

Effects of early physical maturation and accelerated pubertal changes on symptoms of major depression were examined in 639 African American children. Three rival hypotheses, early timing, off-time, and stressful change, were tested using 2 waves of data (mean ages = 11 and 13 years). The pubertal effect operates differently according to children's gender and age. For girls, early maturation was consistently associated with elevated levels of depressive symptoms. For boys, early maturers manifested elevated levels of depression only at age 11, but these symptoms subsided by age 13. Boys who experienced accelerated pubertal growth over time displayed elevated symptom levels. Results support the early timing hypothesis for girls and the stressful change hypothesis for boys. Time at assessment is critical when examining boys' pubertal transition.

Examining culturally based variables associated with ethnicity: influences on credibility perceptions of empirically supported interventions.

Treatment rationales for 2 widely used and empirically supported interventions, cognitive therapy (CT) and time-limited dynamic psychotherapy (TLDP), were examined for their perceived credibility among 136 Asian American college students. This study conducted a comprehensive analysis of culturally based variables (often assumed to underlie ethnicity) and their related effects on credibility perceptions. Variables assessed included cultural identity, self-construals, values, and mental health beliefs. Participants were randomly assigned to read either a CT or TLDP treatment rationale for depression and then rated the credibility of the interventions. Results indicated that cultural identity and self-construals moderated credibility ratings across CT and TLDP rationales. Findings underscore the importance of moving beyond ethnic group analyses to the examination of specific culturally based variables.