RESUMO
Skin penetration amounts of a highly lipophilic drug, ufenamate, prepared in four oily vehicles, including white petrolatum (WP), liquid paraffin (LP), isopropyl myristate (IPM), and isocetyl stearate (ICS), were compared. Ufenamate was mixed in each vehicle at 5% and applied at a rate of 2 mg/cm2 to intact, stripped, and delipidized Yucatan micropig skin. The amounts of ufenamate and IPM in the stratum corneum (SC), epidermis, and dermis were determined. The skin penetration amounts of ufenamate from liquid oils were significantly higher than those from WP; the amounts of ufenamate were in the order WPAssuntos
Portadores de Fármacos/metabolismo
, Ácido Flufenâmico/análogos & derivados
, Óleos/metabolismo
, Absorção Cutânea/fisiologia
, Animais
, Portadores de Fármacos/química
, Portadores de Fármacos/farmacologia
, Ácido Flufenâmico/metabolismo
, Ácido Flufenâmico/farmacologia
, Óleos/química
, Óleos/farmacologia
, Técnicas de Cultura de Órgãos
, Absorção Cutânea/efeitos dos fármacos
, Suínos
, Porco Miniatura