RESUMO
Various external photosensitizers have been compared in local PUVA therapy of 280 patients with psoriasis treated in Moscow at the Central Research Institute for Skin and Sexually Transmitted Diseases, the USSR Ministry of Health, and in Warsaw at the Dermatology Hospital. In Moscow 127 patients have been administered 0.3% ammifurin solution, 73 ones 0.1% psoralen solution; in Warsaw 50 patients have been administered 0.1% puvaderm ointment (Basan) made in Finland and 30 patients 0.1% oxoralen emulsion manufactured in Austria. A good clinical effect has been achieved in 252 patients (90%). Ammifurin 0.3% solution and puvaderm 0.1% ointment have proved to be the most effective. External photosensitizers are recommended for local or as a supplement to total PUVA therapy.
Assuntos
Terapia PUVA/métodos , Psoríase/tratamento farmacológico , Adolescente , Adulto , Idoso , Avaliação de Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polônia , Radiossensibilizantes/uso terapêutico , U.R.S.S.RESUMO
Rheological properties of the blood in 50 psoriasis patients were studied during PUVA-therapy. The mean rheological indices in half of the patients were above normal before treatment. During the PUVA-therapy the mean indices in this group of patients were near to normal. Bimodal distributions of the obtained indices were connected neither with each other, nor with the form and severity of the disease. Lack of statistical correlation links between quantitative indices of systems defining an aggregate state of the blood leads one to believe that changes in rheological properties of the blood in psoriasis patients before treatment can be connected with the immune status of the major disease. Further research in this field is needed.