RESUMO
A fixed drug eruption consists of erythematous patches that appear on the skin and/or mucous membranes following administration of a drug which, once healed, leaves residual hyperpigmentation. We report a 76-year-old male who presented to the Thriasio General Hospital, Athens, Greece, in 2016 with erythema, oedema and blistering of the lower lip and glans penis following the administration of silodosin for benign prostatic hyperplasia. The eruption regressed two weeks after silodosin was discontinued.
Assuntos
Toxidermias/complicações , Indóis/efeitos adversos , Mucosa Bucal/anormalidades , Pênis/anormalidades , Antagonistas Adrenérgicos alfa/administração & dosagem , Antagonistas Adrenérgicos alfa/efeitos adversos , Antagonistas Adrenérgicos alfa/uso terapêutico , Idoso , Diagnóstico Diferencial , Eritema/etiologia , Grécia , Humanos , Indóis/administração & dosagem , Indóis/uso terapêutico , Masculino , Mucosa Bucal/imunologia , Hiperplasia Prostática/complicações , Hiperplasia Prostática/tratamento farmacológicoRESUMO
Angiogenesis has been considered to be an important step in the initiation and progression of chronic diseases such as psoriasis. The hypoxia inducible factor 1 alpha (HIF-1α), a critical hypoxia-induced factor that regulates angiogenesis has been shown previously to be over-expressed in psoriasis skin both at the mRNA and protein level. In this report we confirm HIF-1α and IL-6 over-expression in psoriatic patients using immunoenzymometric assay and found that the expression of HIF-1α is closely correlated with IL-6 expression (r = 0.61 and p = 0.005), suggesting a close interaction of HIF-1α and IL-6 in the psoriasis immuno-microenvironment. Our findings merit further in vitro and in vivo work before solid suggestions can be made for therapeutic interventions that target HIF-1α pathway and/or IL-6.
Assuntos
Subunidade alfa do Fator 1 Induzível por Hipóxia/sangue , Interleucina-6/sangue , Psoríase/sangue , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Expression of hypoxia inducible factor 1 (HIF-1) alpha can be linked to inflammation through reciprocal interactions with several cytokines. This finding is in accordance with the previously noted HIF-1 alpha overexpression in psoriatic lesional keratinocytes. METHODS: In this study we have employed a carefully selected panel of antibodies and quantitative morphometric analysis to compare HIF-1 alpha immunoreactivity in psoriatic biopsy samples vs. that in samples obtained from psoriasiform dermatitides. RESULTS: We found statistically significant HIF-1 alpha overexpression in psoriasis. Furthermore, we observed a previously unreported preferential localization of immunoreactive keratinocytes in the immediate vicinity of inflamed and elongated papillae. This pattern of immunoreactivity may partially account for the observed increase of HIF-1 alpha immunostaining in psoriasis. CONCLUSIONS: Overall, our findings imply that possible novel therapeutic intervention(s) on the HIF-1 alpha pathway may offer another approach in controlling the inflammatory activity of psoriatic lesions.
Assuntos
Dermatite/metabolismo , Subunidade alfa do Fator 1 Induzível por Hipóxia/biossíntese , Psoríase/metabolismo , Dermatite/patologia , Humanos , Imuno-Histoquímica , Queratinócitos/metabolismo , Queratinócitos/patologia , Psoríase/patologiaAssuntos
Adenocarcinoma/complicações , Dermatoses Faciais/etiologia , Granuloma/etiologia , Neoplasias da Próstata/complicações , Adenocarcinoma/terapia , Idoso , Dermatoses Faciais/patologia , Dermatoses Faciais/terapia , Granuloma/patologia , Granuloma/terapia , Humanos , Masculino , Neoplasias da Próstata/terapiaRESUMO
We report a man aged 68 years old with pneumothorax and chronic bilateral pleural effusion in association with a history of yellow nails. The diagnosis of yellow nail syndrome based on yellow nails, lymphedema, chronic pleural effusion and intestinal lymphangiectasia.