RESUMO
The influence of new exopolysaccharide, synthesized by Candida tropicalis and Pseudomonas sp. consortium in ethanol, on the animal body was studied in chronic experiments conducted in 200 non-inbred white rats. The animals were sacrificed after 3, 10 and 18 months of follow-up. The results of the investigations permit a conclusion that exopolysaccharide given to the animals during a long period does not produce a significant effect on the animal's growth and development, on the antitoxic function of the liver, on the parameters of protein, lipid and carbohydrate metabolism, on oxidizing phosphorylation in the mitochondria of the liver, and is low-hazard with respect to allergenic properties.
Assuntos
Peso Corporal/efeitos dos fármacos , Candida/metabolismo , Fígado/metabolismo , Polissacarídeos Bacterianos/farmacologia , Polissacarídeos/farmacologia , Pseudomonas/metabolismo , Administração Oral , Ração Animal , Animais , Biotransformação/efeitos dos fármacos , Biotransformação/fisiologia , Peso Corporal/fisiologia , Fígado/efeitos dos fármacos , Fosforilação Oxidativa/efeitos dos fármacos , Polissacarídeos/administração & dosagem , Polissacarídeos/biossíntese , Polissacarídeos Bacterianos/administração & dosagem , Polissacarídeos Bacterianos/biossíntese , RatosRESUMO
The authors studied the epidemiological situation in a surgical clinic on the basis of examination of 12,000 case histories in the course of several years. Microbiological examinations were carried out of 1438 samples with the purpose of assessing the microbial picture of the wounds of patients and all factors of the environment which could participate in infection due to pathogens of conventional nature. The most frequent pathogens of the wounds were staphylococci--65.6 +/- 6.0%. In the course of observation one established a continuous chain of infections due to presence of sources of pathogens of wound infections, the carriers of which were medical staff, medical students and patients in 19 +/- 2.8%.
Assuntos
Infecção Hospitalar/transmissão , Pseudomonas aeruginosa/isolamento & purificação , Staphylococcus aureus/isolamento & purificação , Infecção da Ferida Cirúrgica/microbiologia , Infecção Hospitalar/microbiologia , HumanosRESUMO
The authors present the results obtained in the survey of graduates from the sanitary and hygienic departments of 4 medical institutes of the Ukrainian SSR carried out in a special pedagogical experiment with the aim to determine the "survival" of their knowledge in epidemiology. As a result, variations in the stability of knowledge in different branches of this discipline, especially in disinfection, the problems requiring the integration of knowledge in epidemiology and hygiene (municipal and alimentary), etc., have been revealed. The authors propose some measures for the improvement of teaching.