RESUMO
In this study it has been shown that infection of mother rats by Borna disease virus (BDV) from infected newborns led to a fatal disease. This differed both in clinical symptoms and in histological alterations from the form of the disease which occurred after intracerebral (i.c.) infection. Both parameters were, however, similar to those seen after experimental intranasal (i.n.) infection of adult rats. Detailed immunohistological studies showed clearly that after experimental i.n. infection, the infecting virus migrates intraaxonally from the neuroreceptors in the olfactory epithelium into the brain. It is therefore suggested that i.n. transmission is an important route of natural BDV infection.
Assuntos
Animais Recém-Nascidos/microbiologia , Doença de Borna/transmissão , Sistema Nervoso Central/microbiologia , Córtex Cerebral/patologia , Condutos Olfatórios/microbiologia , Animais , Anticorpos Monoclonais/imunologia , Antígenos Virais/imunologia , Transporte Axonal , Doença de Borna/microbiologia , Vírus da Doença de Borna/imunologia , Vírus da Doença de Borna/isolamento & purificação , Córtex Cerebral/imunologia , Córtex Cerebral/microbiologia , Feminino , Imuno-Histoquímica , Bulbo Olfatório/imunologia , Bulbo Olfatório/microbiologia , Mucosa Olfatória/imunologia , Mucosa Olfatória/microbiologia , Condutos Olfatórios/imunologia , Ratos , Ratos Endogâmicos LewRESUMO
There are age-dependent differences in the tissue distribution of Borna disease (BD) virus in rats infected intracerebrally. While in adult rats BD virus replication is restricted to neural cells, in neonatally infected rats infectious virus or viral antigens were found in the cells of most organs. The possibility that differences in the immune status between newborn and adult animals are responsible for different tissue susceptibility could be excluded.