[Effect of hardware balance trainings on postural control, risk of falls and cognitive function on elderly people with chronic cerebral ischemia. (Randomized controlled trial)]. / Vliyanie apparatnykh metodik trenirovki balansa na risk padenii, postural'nyi kontrol' i kognitivnye funktsii u pozhilykh lyudei s khronicheskoi ishemiei golovnogo mozga. (Randomizirovannoe kontroliruemoe issledovanie).

INTRODUCTION: As a prevention of falls in elderly people with chronic cerebral ischemia, it is necessary to carry out rehabilitation measures with the inclusion of training aimed at improving statolocomotor and cognitive functions, improving proprioceptive sensitivity and reaction speed to external stimuli. AIMS: To compare the effectiveness of inclusion of hardware balance training on Huber («LPG-Systems¼, France) and C-mill («Physiomed Elektromedizin AG¼, Germany) simulators in complex postural control rehabilitation programs for elderly patients with chronic cerebral ischemia (CCI). MATERIAL AND METHODS: The study included 48 patients (19 men, 29 women), 81% of whom had moderate cognitive impairment. The median age was 76.2±8.5 years. The median Morse scale score before rehabilitation was 50.2 (CI 74-80). The patients were divided into three groups by randomization method: the patients of the 1st comparison group (n=16) were assigned to the Huber stabilizer; the patients of the 2nd comparison group (n=16) underwent training on the track with BOS-video reconstruction of walking «C-mill¼; the patients of the control group (n=16) underwent the course of therapeutic gymnastics according to the developed method. The duration of the course in each group amounted to 8 therapeutic procedures. In the dynamics of the conducted trainings we evaluated: the risk of falls, parameters of postural disorders in statics and dynamics, as well as criteria determining cognitive dysfunction and quality of life of patients. RESULTS: A pronounced improvement of static and dynamic postural indices was observed in the first comparison group, where there was a significant improvement of stabilometric indices: «SL¼ (p=0.001), amplitude of saggital sway (p=0.014), walking speed (p=0.001) and percentage of hitting the marks (p=0.001). The second comparison group showed significant improvement in dynamic balance parameters: walking speed (p=0.001), stride width (p=0.006), percentage of hitting the marks (p=0.001). CONCLUSION: Training on rehabilitation simulators according to the applied methods contributed to the improvement of fall risk related indicators as well as the effectiveness of improving motor performance in older adults with HIM compared to the control group. However, training on the stable-platform induced more significant clinical effects on both static and dynamic balance.

[Analysis of the effectiveness of various methods of rehabilitation of patients with subacromial impingement syndrome]. / Analiz effektivnosti primeneniya razlichnykh metodov reabilitatsii patsientov s subakromial'nym impindzhment-sindromom.

INTRODUCTION: Subacromial impingement syndrome is a common pathology that leads to a persistent decrease in the functioning of the affected limb and, as a consequence, a decrease in the quality of life and work ability of patients. According to various authors, the study of the effectiveness of treatment and rehabilitation of this pathology is quite widely presented in the literature: surgical, including arthroscopic operations, rehabilitation using various factors of physical therapy, manual and other practices. However, the issue of assessing the effectiveness of movement therapy, both alone and in combination with other therapeutic methods, remains relevant. AIM: To evaluate the effectiveness of therapeutic gymnastics procedures, both monotherapy and in combination with manual massage according to the therapeutic method and extracorporeal shock wave therapy (ESWT), in patients with subacromial impingement syndrome of the shoulder, in order to reduce pain and improve the function of the shoulder joint. MATERIAL AND METHODS: The study included 70 patients whose age was 42.18±10.42 years. Patients were divided into two main groups: group 1 (n=34) and group 2 (n=36). All patients received a course of treatment, including 10 procedures of therapeutic exercises, with recommendations at the end of the course for continuation in the form of independent studies using the proven methodology. The duration of the course of therapeutic exercises (in the form of procedures with a physical therapy instructor and subsequent independent studies) was 30 days. Patients in group 2 were divided into three subgroups: subgroup 2A, in which PH procedures were combined with massage of the cervical-collar area and the upper limb area of the affected side; subgroup 2B, where PH gymnastics was carried out in combination with extracorporeal shock wave therapy (ESWT) procedures; subgroup 2C - a comprehensive program including LH procedures, manual massage and shock wave therapy. RESULTS: 3 months after the end of the course of rehabilitation measures, patients of all groups showed a significant improvement in scores on the ASES and VAS scales, but there were no reliably significant differences between the results of different groups. CONCLUSION: The study indicates that movement therapy is an effective method of rehabilitation for patients with subacromial impingement syndrome, and conducting complex programs in which PH is combined with other rehabilitation methods (massage, shock wave therapy) doesn't have statistically significant advantages over PH alone within a 3-month observation period.

[Non-drug technologies in restoring endometrial receptivity as a cause of impaired fertility in women of reproductive age. (Literature review)]. / Nemedikamentoznye tekhnologii v vosstanovlenii retseptivnosti endometriya kak prichiny narusheniya fertil'nosti u zhenshchin reproduktivnogo vozrasta. (Obzor literatury).

Globally, 13% of the population has difficulty conceiving. In Russia, the proportion of infertile marriages ranges from 8 to 17.5%, with half of all forms of female infertility being the uterine form. The main etiological factors for impaired endometrial receptivity are infectious diseases leading to the development of chronic endometritis (most often found in tuboperitoneal infertility), dishormonal background associated with the development of hyperplastic processes in endocrine infertility, uterine fibroids, chronic endometritis and endometriosis. The frequency of detection of uterine cavity diseases in patients with repeated unsuccessful IVF programs ranges from 18 to 50%. The review examines the etiological factors and other causes of endometrial pathology leading to the development of chronic endometritis, possible mechanisms for the development of impaired growth and receptivity of the endometrium, and, as a consequence, the impossibility of pregnancy. Therapeutic strategies for restoring endometrial thickness and receptivity using pharmacological and non-pharmacological methods are described. Based on the analysis of literature data, it is shown that the use of physiotherapeutic factors in treatment programs that have pronounced anti-inflammatory, immuno- and hormone-modulating, reparative-regenerative, metabolic, vasocorrective and defibrosing effects allows for a relatively short period of time to improve endometrial receptivity, normalize hormonal levels and restore fertility in women of reproductive age, which ensures the possibility of successful embryo implantation, fetal development and childbirth.

[Possibilities of physiotherapy methods for improving the microcirculation of the affected limb in patients with spasticity after acute cerebral circulation during the late recovery period]. / Vozmozhnosti metodov fizioterapii dlya uluchsheniya mikrotsirkulyatsii porazhennoi konechnosti u bol'nykh so spastichnost'yu, perenesshikh ostroe narushenie mozgovogo krovoobrashcheniya, v pozdnii vosstanovitel'nyi period.

The significant prevalence of acute cerebral circulatory disorders, the complexity and persistence of disorders of the functions of the upper and lower extremities, which are accompanied by prolonged and persistent disability, is an important medical and social problem. OBJECTIVE: Development of optimized programs of medical rehabilitation in patients after acute cerebrovascular accident in the late recovery period. MATERIAL AND METHODS: The study included 200 patients who suffered acute cerebral circulatory disorders, with increased muscle tone in the lower extremity by the type of spasticity in the late recovery period, who were divided into five groups comparable in clinical and functional characteristics and age: the 1st group (n=40) - patients who, in addition to the standard complex of therapy and rehabilitation, the same in all five groups and including therapeutic physical culture, medical massage and kinesiotherapy, received low-frequency electrostatic massage, complex multimodal effects from the Alpha-capsule apparatus, training on a multifunctional biofeedback (BFB) platform and training of the stereotype of walking on to the track by the method of imposition; the 2nd group (n=40) - patients who, in addition to the standard complex, received low-frequency electrostatic massage from the Khivamat apparatus and exposure to broadband modulation currents; the 3rd group (n=40) - patients who, in addition to the standard complex, received a complex multimodal effect from the Alpha-capsule; the 4th group (n=40) - patients who, in addition to the standard complex, received training on a multifunctional platform with barefoot and training of the stereotype of walking on the track by the method of imposition; the 5th group (n=40) - patients who received only a standard complex of therapy and rehabilitation. RESULTS: At all control points (after the course of treatment, after 6 and 12 months), in addition to general clinical and neurological studies, microcirculation parameters were evaluated by laser Doppler flowmetry. In dynamics, it was revealed that in the 1st, 2nd, and 4th groups there was a significant improvement in microcirculation in the affected limbs, to a lesser extent, this significant improvement in microcirculation was noted in the 3rd group; in patients of the 5th group, only a positive trend was noted. CONCLUSION: Inclusion in the standard rehabilitation complex of low-frequency electrostatic massage, multimodal physiotherapy and training on a multifunctional platform with BFB COBS in combination with walking stereotype training with video instruction using the system with BFB C-Mill in patients who have suffered acute cerebrovascular accident, with motor disorders in the form of hemiparesis with increased muscle tone of the lower extremity in the late recovery period causes a significant improvement in microcirculation in the arteriolar-venular bed of the affected lower extremities, which may underlie the improvement of static-locomotor indicators and contribute to the expansion of the volume of movements in the joints of the lower extremities.

[The use of stability training in rehabilitation programs in patients after total knee replacement in the late recovery period]. / Primenenie stabilotreninga v programmakh reabilitatsii u patsientov posle total'nogo endoprotezirovaniya kolennogo sustava v pozdnem vosstanovitel'nom periode.

All over the world, total joint replacement is one of the most common and popular surgical technology. The frequency of knee replacement is steadily increasing. The development of new rehabilitation technologies for patients after total knee replacement is an urgent problem of modern healthcare. OBJECTIVE: To evaluate the effect of physical training using a stabiloplatform and a standard scheme of medical rehabilitation on the restoration of the walking stereotype, the state of locomotor function and hemodynamic parameters of the affected lower limb in patients after total knee replacement in the late recovery period. MATERIAL AND METHODS: 60 patients were examined three months after total arthroplasty of the joints of the lower limb aged 55 to 80 years, who were divided into two groups comparable in clinical and functional characteristics: the 1st group - 30 people, who in addition to the standard scheme of medical rehabilitation, were trained using a stabilometric complex with biofeedback for recovery functions of balance and symmetry of movements; the 2nd group - 30 people, who have undergone a course of medical rehabilitation (physical therapy and medical massage according to the standard method). The state of the microcirculatory bed in the affected limb was assessed using laser Doppler flowmetry, data on static-locomotor disorders (before and after treatment) were analyzed. RESULTS: The data obtained indicate the advantage of including physical training aimed at restoring impaired locomotor function, balance and symmetry of movements in the standard scheme of medical rehabilitation of patients after total knee replacement of the lower limb. In the course of the study, it was revealed that training with biofeedback helps to improve the overall capillary blood flow in the affected lower limb and normalize the indicators of static-locomotor functions. CONCLUSION: The inclusion of physical training to restore static balance and symmetry of movements in the standard complex of medical rehabilitation of patients after total knee replacement in the late recovery period significantly improves microcirculation in the affected limb and normalizes motor functions and skills.

[Clinical efficacy of rehabilitation measures in patients with melanoma of the skin undergoing immunotherapy]. / Klinicheskaya effektivnost' reabilitatsionnykh meropriyatii u patsientov s melanomoi kozhi, nakhodyashchikhsya na immunoterapii.

BACKGROUND: Currently one of the urgent problems of oncology is he choice of tactics of rehabilitation measure. Despite the long list of known possible side effects from antitumor therapy, most patients do not receive follow-up and preventive interventions necessary to correct clinically significant consequences. OBJECTIVE: Analysis of clinical effectiveness of complex rehabilitation programs in patients with melanoma of skin receiving immunotherapy. MATERIAL AND METHODS: The study included 109 patients with metastatic melanoma, aged 26 to 88 years, who received immunotherapy in the period from 2019 to 2022. The study group (n=54) included patients who received a comprehensive rehabilitation program: physical therapy, nutritional support, general magnetotherapy, psychotherapy sessions without concomitant medications. Patients who did not use rehabilitation programs made up the control group (n=55). The effectiveness of therapy was evaluated in accordance with iRECIST 1.1 criteria. Immuno-mediated toxity of treatment was evaluated according to CTCAE criteria (version 5.0, 2017). To assess the quality of life (QoL), the EORTC QLQ-C30 questionnaire was used. RESULTS: The median follow-up of patients was 20 weeks in the study group, 19 weeks in the control group. Stabilization of the disease was achieved in 21 (38.9%) patients of the study group and 23 (41.8%) patients of the control group; disease progression in both groups was comparable: 10 (18.5%) - in the study group, 12 (21.8%) - in the control group. Adverse events of therapy were detected in 39 (72.2%) patients of the study group, 46 (83.6%) patients of the control group. All registered adverse events according to CTCAE 5.0 criteria were of grade I-II. No serious adverse events of the IV degree were detected during the study period. CONCLUSION: The introduction of comprehensive rehabilitation programs in the treatment of patients with melanoma shows its effectiveness and reduced toxicity of immunotherapy, however, there are a number of important issues that require further resolution.

[The role of nutrition status correction in the rehabilitation of cancer patients]. / Rol' korrektsii nutritivnogo statusa v reabilitatsii onkologicheskikh patsientov.

Metabolic changes due to the progression of malignant neoplasms and the negative consequences of aggressive methods of its treatment lead to a decrease in food intake in patients, which contributes to the development of anorexia-cachexia syndrome in cancer patients due to complex interactions between pro-inflammatory cytokines and host metabolism. Within the framework of this article, the author analyzes the possibility of the influence of nutritional status in cancer patients. The analysis of the results of the study of a group of cancer patients with various nutritional statuses was carried out. It is concluded that the control and correction of nutritional status should become an integral part of the assessment of the quality of life and meet the needs and expectations of the patient.

[Recovery of social and everyday skills after a complex of functional spatially oriented rehabilitation in elderly patients with cerebral stroke]. / Otsenka effektivnosti vosstanovleniya sotsial'no-bytovykh navykov s ispol'zovaniem kompleksa funktsional'noi prostranstvenno-orientirovannoi reabilitatsii u pozhilykh patsientov s tserebral'nym insul'tom.

OBJECTIVE: To analyze the effectiveness of social recovery (trip to the store by bus and making purchases) in elderly patients with stroke in the right middle cerebral artery undergoing a course of specialized trainings in a complex of functional spatially oriented rehabilitation. MATERIAL AND METHODS: The study involved 44 patients with previous stroke (mean age 70.8±3.1 years) randomized into 2 equal groups: main group - basic standard of rehabilitation (exercises with instructor, mechanotherapeutic technique with cyclic simulators, massage of paretic limbs) and training of social adaptation in a complex of functional spatially oriented rehabilitation; control group - basic standard of rehabilitation alone. Duration of rehabilitation course was 14 days. To determine mean norm of timing of complex training of socially significant skill, we asked 23 volunteers without severe comorbidities to perform tasks of functional spatially oriented rehabilitation. RESULTS: After complex rehabilitation program, we found significant dynamics of time necessary for the following actions: "take a bag and hang it over shoulder", "open the pockets of the bag with a zipper (2 pockets)", "take the jacket off the hanger and put it on", "take the products from the basket and put in the pocket". Moreover, the main group was characterized by significantly lower impairment of daily activity (Barthel score 66.3±4.5 vs. baseline 45.7±4.9, p<0.05), improvement of functional independence (FIM score 76.7±1.5 vs. baseline 65.2±3.1, p>0.05). These values turned out to be significantly better than in the control group. CONCLUSION: These results indicate the effectiveness of functional spatially oriented rehabilitation in elderly patients with cerebral stroke. This approach increases personal independence in daily life and improves overall quality of life.

[Hypoxic training in rehabilitation of patients at the early stages of recovery after SARS-CoV-2 pneumonia]. / Rol' gipoksicheskikh trenirovok v reabilitatsii patsientov na rannikh srokakh vosstanovleniya posle pnevmonii, vyzvannoi virusom SARS-CoV-2.

OBJECTIVE: To evaluate efficacy and safety of hypoxic-hyperoxic therapy in rehabilitation after SARS-CoV-2 pneumonia. MATERIAL AND METHODS: There were 44 patients aged 49-75 years in early recovery period after previous SARS-CoV-2 pneumonia (ICD-10 U07.1 and U07.2). Patients were divided into 2 groups depending on treatment strategy: group 1 (n=23) - rehabilitation treatment with therapeutic exercises, massage and physiotherapy; group 2 (n=21) - basic procedures with hypoxic-hyperoxic therapy. RESULTS: At initial evaluation, we found positive tendencies of rehabilitation in both groups. There were no side effects associated with hypoxic-hyperoxic therapy in the second group. Patients positively perceived this method of rehabilitation. There were significant between-group differences in exercise tolerance (p<0.05). These data indicate more favorable physical recovery in the second group and similar improvement of psycho-emotional status in both groups. CONCLUSION: Hypoxic-hyperoxic therapy is effective and safe approach in rehabilitation of patients with previous SARS-CoV-2 pneumonia. It is necessary to continue searching for effective methods of rehabilitation and develop accurate rehabilitation methods for various groups of patients.

[Efficiency of balance training with stabilizing platform in early postoperative rehabilitation of patients after arthroplasty]. / Effektivnost' vklyucheniya balans-treninga s ispol'zovaniem stabiloplatformy v kompleksnye programmy rannei posleoperatsionnoi reabilitatsii patsientov posle endoprotezirovaniya.

OBJECTIVE: To evaluate the effectiveness of balance training on stabilizing platform (HUBER360) in early postoperative rehabilitation of patients after total knee arthroplasty. MATERIAL AND METHODS: We examined 60 patients after total knee arthroplasty. Mean age of patients was 69.1±9.8 years, mean postoperative period - 3.6±1.4 days. All patients were divided into 2 groups (main group (n=30) and control group (n=30)). All patients received a standard course of treatment, including therapeutic exercises, massage of affected lower in electro-static field limb using a drainage technique, magnetotherapy, mechanotherapy of affected limb in passive motor mode (Artromot device). Duration of rehabilitation course in a round-the-clock hospital was 7 days. In the main group, patients additionally received balance-training procedures on the HUBER 360 multiaxial platform in baseline sitting position. RESULTS: Treatment was followed by positive dynamics in all patients that correlated with significant regression of pain syndrome, edema, improvement of quality of life and 10-meter walk test with external support on crutches. However, additional balance training provided more effective regression of pain, as well as improvement of quality of life and walking after the first procedures. CONCLUSION: We can recommend balance training on stabilizing platform for early rehabilitation after total knee arthroplasty.

[The role of systemic ozone therapy in the rehabilitation of patients after COVID-19]. / Rol' sistemnoi ozonoterapii v reabilitatsii patsientov, perenesshikh COVID-19.

OBJECTIVE: To evaluate the effectiveness and safety of ozone therapy in rehabilitation of patients with previous COVID-19. MATERIAL AND METHODS: A randomized controlled clinical trial included 51 patients aged 29 - 78 years with SARS-CoV-2 pneumonia (J12.8). Patients were divided into 3 comparable groups depending on the complex of rehabilitation. In the first (control) group (n=17), a 10-day course included daily breathing exercises and physiotherapy for the lungs (drug electrophoresis and low-frequency magnetotherapy). In the second (main) group (n=18), rehabilitation was combined with daily intravenous infusions of ozonized saline with ozone concentration of 2.0 mg/l within 5 days with subsequent standard rehabilitation. In the third group (n=16), patients received 5 ozone therapy procedures every other day. To determine the effectiveness and safety of systemic ozone therapy in rehabilitation of patients with previous COVID-19, we analyzed oxygen saturation, laboratory data (D-dimer and C-reactive protein), need for oxygen support before and after rehabilitation course. Complaints and quality of life throughout the rehabilitation program were assessed using the EQ-5D questionnaire. RESULTS: All patients had positive changes of all parameters. There were no adverse reactions throughout the rehabilitation program and 2 months later. We observed higher effectiveness of rehabilitation with systemic ozone therapy. Moreover, daily ozone therapy had a better effect on laboratory parameters compared to ozone therapy every other day. CONCLUSION: Ozone therapy is safe and effective in complex rehabilitation of patients with previous COVID-19. Further studies of large samples are needed to determine indications and appropriate criteria for this rehabilitation program.

[Comprehensive rehabilitation of immune-mediated adverse events in cancer patients receiving checkpoint inhibitor therapy]. / Kompleksnaya reabilitatsiya immunooposredovannykh nezhelatel'nykh yavlenii u patsientov so zlokachestvennymi opukholyami, poluchayushchikh terapiyu ingibitorami kontrol'nykh tochek.

OBJECTIVE: To evaluate adverse events and clinical effectiveness of complex rehabilitation programs in patients with malignant tumors receiving checkpoint inhibitor therapy. MATERIAL AND METHODS: The study included 144 cancer patients who received immunotherapy for the period from 2019 to 2021. Group 1 consisted of 72 patients who received a comprehensive rehabilitation program including physical therapy, diet therapy, psychotherapy, general magnetotherapy. Patients of the second (control) group (n=72) did not receive rehabilitation procedures. Effectiveness of treatment was evaluated according to RECIST 1.1 criteria, safety of treatment - according to CTCAE criteria (version 5.0, 2017). To assess the quality of life (QoL), the Russian version of the EORTC QLQ-C30 questionnaire was used. RESULTS: Mean follow-up period in the first group was 4.5 months, in the control group - 5 months. Disease progression was observed in 35 (48.6%) patients of the main group and 32 (44.4%) patients of the control group. Two (2.8%) patients in the control group demonstrated complete response to therapy. Partial response was established in both groups in 13 patients (18.1%). Stabilization of disease was detected in 24 (33.3%) and 25 (34.7%) patients, respectively. Adverse events were registered in 54 (75.0%) and 60 (83.3%) patients, respectively. Adverse events grade III-IV occurred in 9.7% and 11.1% of patients, respectively. CONCLUSION. I: Mmunotherapy combined with comprehensive rehabilitation program confirms high effectiveness of these drugs. We observed good tolerability of rehabilitation procedures that do not deteriorate the course of the underlying disease. However, there are certain important issues, in particular influence of rehabilitation procedures on tolerability of immunotherapy in patients with cancer.

[Effectiveness of physical therapy after total hip arthroplasty at the third stage of rehabilitation using a telemedicine program]. / Effektivnost' provedeniya lechebnoi gimnastiki u patsientov posle endoprotezirovaniya na tret'em etape reabilitatsii v forme telemeditsinskikh uslug.

OBJECTIVE: To assess the quality of life and efficacy of telemedicine technologies for rehabilitation after total hip replacement. MATERIAL AND METHODS: The study included 60 patients aged 40-75 years after total hip replacement. All patients were divided into two groups by simple randomization. All patients underwent a 7-day course of complex in-hospital postoperative rehabilitation. At discharge, patients of the main group received an access to telemedicine program for 3-month physical exercises (3 times a week for 30 minutes). In the control group, patients received routine recommendations for rehabilitation procedures and orthopedic recommendations. RESULTS: A course of rehabilitation with telemedicine technologies after total hip replacement was accompanied by significant clinical effect according to EQ5D, SF-36 and STAI questionnaires. CONCLUSION. T: Elemedicine technologies in postoperative rehabilitation after total hip replacement are accompanied by QoL improvement. It is an effective form of medical rehabilitation.

[Influence of therapeutic exercises and hardware massage in electrostatic field on lung damage in patients with novel coronavirus pneumonia]. / Otsenka vliyaniya lechebnoi gimnastiki i apparatnogo massazha v elektrostaticheskom pole na stepen' porazheniya legkikh u patsientov s pnevmoniei pri novoi koronavirusnoi infektsii.

OBJECTIVE: To analyze the efficacy and safety of therapeutic exercises and chest hardware massage in electrostatic field in patients with COVID-associated viral pneumonia. MATERIAL AND METHODS: We retrospectively analyzed 1551 patients admitted to the Clinical Hospital No. 1 (MEDSI Group JSC) with COVID-associated pneumonia between April 01, 2020 and June 15, 2021 (ICD-10 U07.1 and U07.2). Considering inclusion and exclusion criteria, we enrolled 153 patients. All patients were divided into comparable groups and subgroups depending on the methods of rehabilitation treatment and CT stage of viral pneumonia. Lung damage was assessed semi-automatically using Philips Portal v11 COPD software. Rehabilitation measures included therapeutic exercises and chest hardware massage in electrostatic field. therapeutic exercises. RESULTS: Therapeutic exercises significantly reduced severity of lung damage in patients with viral pneumonia CT-2 and no oxygen support (from 28.05% [28; 29.5] at admission to 15.3% [14.2; 19.3] at discharge). It was not observed in patients without rehabilitation treatment and in patients undergoing therapeutic exercises and massage in electrostatic field. CONCLUSION: Therapeutic exercises in patients with COVID-19 and baseline lung damage > 25% and < 50% (CT-2 stage) significantly reduce severity of lung damage at discharge compared to the control group.

[Magnetotherapy in patients with malignant tumors receiving immunotherapy]. / Opyt primeneniya reabilitatsionnoi magnitoterapii u patsientov so zlokachestvennymi opukholyami, poluchayushchikh immunoterapiyu.

OBJECTIVE: To analyze the quality of life in patients receiving immunotherapy and overall response rate in case of additional magnetotherapy. MATERIAL AND METHODS: The study included 3 cohorts of patients (n=48) with various disseminated malignancies (melanoma, lung cancer, kidney cancer) who received immunotherapy. In the study groups, all patients additionally took courses of rehabilitation based on magnetotherapy. In the control cohorts, patients underwent courses of immunotherapy without additional magnetic therapy. Treatment efficacy was assessed according to iRECIST 1.1 criteria. The Russian version of the EORTC QLQ-C30 questionnaire was used to study the quality of life. We analyzed adverse events using the CTCAE 5.0 criteria. RESULTS: In patients with melanoma, the most common response to systemic treatment was stabilization (41.7% in the study group and 30.8% in the control group). The objective response rate was higher in the study group (33.3% vs. 23.1%). There was also significant improvement in the quality of life after treatment in the study group (by 23.5%). In the control group, the indicator worsened by 4.8%. Overall health improved by 12.8% in the study group and 10.3% in the control group. In patients with lung cancer, response to systemic treatment with stabilization was achieved in 33.3% of patients in the study group and 20% of patients in the control group. The objective response rate was 33.3% and 20%, respectively. Analysis of the study group revealed improvement of overall health by 9.6% and overall quality of life by 38.6%. In the control group, overall health improved by 4.8% and quality of life remained the same. In patients with kidney cancer, the objective response rate was 40% and 42.9%, respectively. Disease stabilization was achieved in 40% and 28.6% of patients, respectively. Overall health improved by 16.7% and 6.3%, overall quality of life - by 19% and 9.1%, respectively. CONCLUSION: Magnetic therapy during the course of immunotherapy improved the overall quality of life and reduced severity of adverse events. Further study of magnetotherapy as an accompanying rehabilitation technique is required.

[Evaluation of the effectiveness of using broadband modulation currents in medical rehabilitation of patients after acute cerebrovascular accident]. / Otsenka effektivnosti primeneniya tokov shirokopolosnoi modulyatsii v meditsinskoi reabilitatsii patsientov posle ostrogo narusheniya mozgovogo krovoobrashcheniya.

Every year in the world more than 15 million patients suffer from acute cerebrovascular accident. A special role in the organization of medical care for patients after acute cerebrovascular accident should be assigned to measures to improve the prevention of clinical manifestations and comprehensive rehabilitation. OBJECTIVE: To study the effect of broadband modulation currents on the manifestations of spasticity and on cognitive functions in patients after an ischemic stroke in the late recovery period. MATERIAL AND METHODS: The article presents data on the effectiveness of the use of broadband modulation currents in the late recovery period of medical rehabilitation of patients with ischemic stroke. The study included 80 patients who underwent ischemic stroke with movement disorders in the form of hemiparesis and increased muscle tone by the type of spasticity in the late recovery period. Control group patients (40 people) underwent standard drug therapy and medical rehabilitation, patients of the main group (40 people) received broadband modulation currents against the background of standard drug therapy and medical rehabilitation. The severity of spasticity and impaired motor function of the arm and leg was assessed according to the modified Ashfort Spasticity Scale (MAS) and goniometry parameters; the analysis of indicators of impairment of cognitive functions according to the data of the Montreal Cognitive Assessment Scale (MoCA) was carried out. RESULTS: After the course of treatment in patients of the main group, at all control points, there was a statistically significant positive dynamics of a decrease in spasticity, both in the proximal and in the distal parts of the upper limb, according to the modified Ashforth Spasticity Scale (MAS), while in the patients of the control group, only positive trend. After the course of treatment, a significant advantage of the influence of the developed method on cognitive impairment of functions in patients of the main group, who received broadband modulation currents, was revealed. This was confirmed by the increase in the total indicator of the MoCA scale to 26.7±0.6 points, which corresponded to the reference values. In patients of the control group, less pronounced results were obtained, the total indicator of the MoCA scale was 25.1±1.0 points, which was below the norm. CONCLUSION: The data obtained indicate that the inclusion of broadband modulation currents in the medical rehabilitation program contributes to a significant decrease in the severity of spasticity, increases the range of motion in the affected limb, and has a positive effect on the cognitive functions of patients.

[Application of modern non-drug technologies to improve the quality of life of patients with hemiparesis]. / Primenenie sovremennykh nemedikamentoznykh tekhnologii dlya povysheniya kachestva zhizni bol'nykh s gemiparezom.

In recent years, the improvement of the system of medical rehabilitation of patients with acute cerebrovascular accident has acquired special social significance due to the high morbidity. OBJECTIVE: To study the effect of the combined use of a multifunctional platform and massage with a pulsed low-frequency electrostatic field on the motor functions of the lower limb, coordination and balance, as well as on the psychoemotional status and quality of life of patients after an ischemic stroke with hemiparesis in the late recovery period. MATERIAL AND METHODS: The article presents data on the treatment of 120 patients who had an ischemic stroke with movement disorders in the form of hemiparesis with an increase in muscle tone by the type of spasticity in the late recovery period. All patients received standard drug therapy and underwent medical rehabilitation. The patients were divided into 3 groups: the main group - 40 patients who received massage with a pulsed low-frequency electrostatic field and training on a multifunctional platform with biofeedback (BFB) - COBS (mtd-Systems, Germany), a comparison group - 40 patients who received training on a multifunctional platform with biofeedback (BFB), control group - 40 patients. RESULTS: In the initial state, all patients included in the study showed an uneven distribution of the load in the protocols «normal standing position¼ and «standing balance¼ with an advantage towards the healthy leg. After the course of treatment in the patients of the main group, all the evaluated indices were normalized, in the patients of the comparison group statistically significant less pronounced results were obtained, and in the patients of the control group only a positive trend was noted. When studying the quality of life and the effectiveness of treatment according to the EQ-5D questionnaire in the examined patients in the initial state, the indicator averaged 7.8±0.8 points. After the course of treatment, the patients of the main group showed a statistically significant decrease in the indicators of the EQ-5D questionnaire from 7.8±0.8 points in the initial state to 5.1±1.1 (p<0.001), which lasted up to 6 months. In patients of the comparison group in all periods of observation, a decrease in the indicator was also noted, but less pronounced, in patients in the control group, only a positive trend. The data were supported by the Hospital Anxiety and Depression Scale (HADS) score. CONCLUSION: The use of complex rehabilitation with the inclusion of a multifunctional platform with biofeedback and electrostatic massage contributes to a pronounced improvement in the functional state of muscle tone, coordination and balance, a significant decrease in the level of anxiety and depression and has a pronounced positive effect on the quality of life and assessment of the health status of patients with hemiparesis in late recovery period after ischemic stroke.

[Influence of complex rehabilitation programs on the uterine blood flow in patients of different age after plastic surgery for rectocele]. / Vliyanie reabilitatsionnykh kompleksnykh programm na pokazateli matochnogo krovotoka po dannym 3D-ekhodopplerografii u patsientok raznykh vozrastnykh grupp posle plasticheskoi operatsii po povodu rektotsele.

OBJECTIVE: To develop the optimized complex programs, including general magnetotherapy, fractional microablative therapy with a CO2 laser, electromyostimulation with biofeedback of the pelvic floor muscles, and a special exercise therapy complex in late rehabilitation programs for women of different age after reconstructive plastic surgery for rectocele. MATERIAL AND METHODS: There were 200 women of childbearing, peri- and menopausal age with rectocele grade II-III and 20 healthy women of comparable age. All patients were divided into 4 groups by 50 womes: main group, two comparison groups and control group. Surgical treatment of rectocele was followed by long-term postoperative rehabilitation including symptomatic therapy, general magnetotherapy, and electromyostimulation with biofeedback of the pelvic floor muscles, intra-vaginal fractional microablative therapy with a CO2 laser and special complex of therapeutic physical education. RESULTS: General magnetotherapy in early (1 day) postoperative period and complex rehabilitation in long-term postoperative period (within a month after surgery) including 2 procedures of intra-vaginal microablative fractional therapy with carbon dioxide laser, electromyostimulation with biological connection of the pelvic floor muscles and special complex of therapeutic physical education ensured more significant improvement of uterine blood flow regardless age and baseline disorders in the uterine arteries in patients with rectocele. In our opinion, this is primarily due to vasoactive effects of general magnetotherapy, recovery of circulation via relief of spasm in the arteries and arterioles, improved vein contractility and venous outflow. These processes combined with electrical stimulation and therapeutic exercises of pelvic floor muscle followed by their reinforcement, as well as fractional microablative therapy ensured significant vascular effect.

[Influence of various rehabilitation complexes on sexual function in fertile females and women of perimenopausal and menopausal age after surgery for rectocele]. / Otsenka vliyaniya razlichnykh reabilitatsionnykh kompleksov na seksual'nuyu funktsiyu u patsientok detorodnogo i perimenopauzal'nogo i menopauzal'nogo vozrasta posle operatsii po povodu rektotsele.

OBJECTIVE: To study the effect of general magnetotherapy, muscle stimulation with biofeedback of pelvic floor muscles, and a special complex of physiotherapy exercises with and without fractional microablative CO2-laser therapy on sexual status in females after plastic surgery for rectocele. MATERIAL AND METHODS: There were 200 fertile females and women of perimenopausal and menopausal age with rectocele grade II-III. Various rehabilitation programs were used in delayed postoperative period in order to improve sexual function. Rehabilitation included various combinations general magnetotherapy, electrical muscle stimulation with biofeedback of pelvic floor muscles, intravaginal fractional microablative CO2-laser therapy and a special complex of exercise therapy. RESULTS AND CONCLUSION: Postoperative rehabilitation including general magnetotherapy, fractional microablative CO2-laser therapy, muscle stimulation with biofeedback of pelvic floor muscles and a special exercise therapy significantly improves sexual function in patients with rectocele. This is true for fertile females and women of perimenopausal and menopausal age. Significant data on PISQ-12 questionnaire (Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire) and Female Sexual Function Index of (FSFI) confirmed these results.

[The hardware techniques for the restoration of the gait stereotype in the patients following total hip replacement: the personalized approach].

BACKGROUND: total hip replacement has long ago become the «golden standard¼ for the treatment of dysplastic coxarthrosis in thousands of the patients receiving it every year. In the meantime, the analysis of the specialized literature gives evidence of the lack of a systematic and personified approach to the rehabilitation treatment. AIM: The objective of the present study was to improve medical rehabilitation of the patients following the total hip replacement and to develop the personalized programs for walking modality reconstruction taking into consideration the age and the body weight of the patients. PATIENTS AND METHODS: A total of 240 patients were available for the observation including 184 women and 56 men. They were divided into three study groups and one control group, with the differentiation into the following three subgroups: one comprised of the patients of moderate acerage age and body weight, the other containing the obese patients (BMI>35), and the third one involving the elderly patients (age >70 years); each subgroup consisted of 20 patients. All the patients received the early basic rehabilitation treatment, those in the study groups had to perform in addition the robotic training based on the use of hardware techniques supplemented by passive mechanotherapy and electromyostimulation designed to restore the walking stereotype with three types of devices: body weight unloading, video-reconstruction associated with biological feedback and robototherapy. RESULTS: The comparative analysis of the effectiveness of various methods of gait reconstruction has demonstrated the high effectiveness of the application of the hardware technique in the patients of moderate acerage age and body weight. At the same time, the elderly patients had a significantly higher rate of successful walking reconstruction efficiency under the influence of the video-associated training with biological feedback (3 times that achieved with training using the device for unloading the body weight and 4 times compared with the result of a course of robotic walk. The evaluation of the application of the techniques for the gait stereotype reconstruction in the obese patients gave evidence of the advantage of the Lokomat robotic trainings that produced 6 times better results than unloading of the body weight and 5 times better ones than the video-associated training with biological feedback. DISCUSSION: The results of the present study are on the whole comparable with the data reported by other authors although its design was different from that of the majority of the published studies in that our patients were allocated to different subgroups for the further personalization of the methods applied to restore the gait stereotype. The factors limiting the use of the results of this study include the medium-high level of the patients' welfare most of whom are residents of the city of Moscow and Moscow region characterized by a relatively high quality and accessibility of health care. It means that the results of such studies as the one described in the present article are directly related to the quality and accessibility of health care and can be extrapolated only to the socially safe and well-to-do patients. CONCLUSIONS: All the hardware techniques are equally effective in the patients of moderate average age and body weight. The elderly patients showed the best results using the video-reconstruction associated with biological feedback, while the Locomat technique was especially useful for the obese patients.