The effects of amlodipine and platelet rich plasma on bone healing in rats.

AIM: The aim of this study was to evaluate the effects of calcium channel blocker (CCB) amlodipine (AML), platelet rich plasma (PRP), and a mixture of both materials on bone healing. MATERIALS AND METHODS: Fifty-six male Wistar rats were randomly divided into four groups: group A, tibia defect model with no treatment; group B, tibia defect model treated with AML, 0.04 mg daily by oral gavage; group C, tibia defect model treated with local PRP; group D, tibia defect model treated with local PRP and AML, 0.04 mg daily by oral gavage. RESULTS: At day 21, bone healing was significantly better in groups C and D compared to group A (P<0.05), but comparisons showed no statistically significant difference in group B (P>0.05). At day 30, groups B and C showed no statistically significant difference (P>0.05) compared to group A, but bone healing in group D was significantly better than in group A (P<0.05). Statistically, AML did not affect alkaline phosphatase (ALP) activity at 21 and 30 days (P>0.05), but PRP and AML + PRP increased ALP activity statistically (P<0.05). CONCLUSION: It can be concluded that AML had neither a positive nor a negative effect on bone healing, but when used in combination with PRP, it may be beneficial.

Displaced lower third molar tooth into the submandibular space: Two case reports.

The aim of this article is to emphasize that the accidental displacement of a lower third molar during extraction is a rare, but potentially serious complication. We present two case reports on a lower third molar tooth dislodged into the submandibular space following its removal from the sockets and the subsequent management of this rare complication. Differences in the direction of displacement, the size of fragment, delay in retrieval, and tissue reactions can all influence this potential serious complication and hence no one technique is uniformly applicable. Though a rare complication, clinicians must be aware of possible lower third molars dislodgement into tissue spaces and the necessity to initiate prompt and appropriate management.