1.
Biochem Biophys Res Commun
; 268(2): 384-9, 2000 Feb 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10679213
RESUMO
We report in this paper the design, by means of computational techniques, of new cyclic urea inhibitors of the HIV aspartic protease. The relationship between the complexation energies of the enzyme with known inhibitors and the experimentally determined log K(i) have been studied and used to predict inhibition constants for new inhibitors.