Two-Dimensional (2D) Hybrid Method: Expanding 2D Correlation Spectroscopy (2D-COS) for Time Series Analysis.

We present a concise report on the two-dimensional (2D) hybrid method, an innovative extension of 2D correlation spectroscopy, tailored for quasar light curve analysis. Addressing the challenge of discerning periodic variations against the background of intrinsic "red" noise fluctuations, this method employs cross-correlation of wavelet transform matrices to reveal distinct correlation patterns between underlying oscillations, offering new insights into quasar dynamics.

Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation.

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were designed as exceptionally safe colloidal carriers for the delivery of poorly soluble drugs. SLN/NLC have the particularity of being composed of excipientsalready approved for use in medicines for human use, which offers a great advantage over any other nanoparticulate system developed from novel materials. Despite this fact, any use of excipients in new route of administration or in new dosage form requires evidence of safety. After 25 years of research on SLN and NLC, enough evidence on their preclinical safety has been published. In the present work, published data on in vitro and in vivo compatibility of SLN/NLC have been surveyed, in order to provide evidence of high biocompatibility distinguished by intended administration route. We also identified critical factors and possible weak points in SLN/NLC formulations, such as the effect of surfactants on the cell viability in vitro, which should be considered for further development.