1.
Chem Biodivers
; 16(10): e1900377, 2019 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31436917
RESUMO
The series of novel Mannich bases were synthesized and evaluated for their inâ vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. The results showed that all compounds were less active than the drugs used as reference, but some of them had moderate potency against Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633. The presence of a phenyl ring in the position 4 of piperazine seems to be necessary for antibacterial activity in this class of compounds.