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Comput Math Methods Med ; 2015: 680434, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26161131

RESUMO

Order-preserving submatrices (OPSMs) have been applied in many fields, such as DNA microarray data analysis, automatic recommendation systems, and target marketing systems, as an important unsupervised learning model. Unfortunately, most existing methods are heuristic algorithms which are unable to reveal OPSMs entirely in NP-complete problem. In particular, deep OPSMs, corresponding to long patterns with few supporting sequences, incur explosive computational costs and are completely pruned by most popular methods. In this paper, we propose an exact method to discover all OPSMs based on frequent sequential pattern mining. First, an existing algorithm was adjusted to disclose all common subsequence (ACS) between every two row sequences, and therefore all deep OPSMs will not be missed. Then, an improved data structure for prefix tree was used to store and traverse ACS, and Apriori principle was employed to efficiently mine the frequent sequential pattern. Finally, experiments were implemented on gene and synthetic datasets. Results demonstrated the effectiveness and efficiency of this method.


Assuntos
Biologia Computacional/métodos , Mineração de Dados/métodos , Algoritmos , Automação , Análise por Conglomerados , Bases de Dados Genéticas , Perfilação da Expressão Gênica , Regulação Fúngica da Expressão Gênica , Análise de Sequência com Séries de Oligonucleotídeos , Reconhecimento Automatizado de Padrão/métodos , Saccharomyces cerevisiae/metabolismo , Software
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