[The pathogenetic aspects of diabetic involvement of the heart]. / Nekotorye patogeneticheskie aspekty diabeticheskogo porazheniia serdtsa.

As many as 107 patients with diabetes mellitus were enrolled in the study. It has been found out that under diabetic metabolic disturbances there occur significant changes in structural-and-functional characteristics of proteins, including myocardial ones, believed to be of much importance to the pathogenesis of diabetic affection of the heart and to the functional state of the myocardium.

[The bioenergetics system of the blood lymphocytes in infectious-allergic myocarditis]. / Sistema bioénergetiki limfotsitov krovi pri infektsionno-allergicheskom miokardite.

46 patients with infectious-and-allergic myocarditis (IAM) and 46 patients with myocarditic cardiosclerosis (MCS) were studied for cytochemical parameters of blood lymphocyte bioenergetics. In IAM, cellular metabolism was found out to be disturbed, with the activity of G-6-PDG in spontaneous NST-test being risen against the background of depression of NAD- and NADP-diaphorases, lowering of the endogenous cytochrome "C" content and activity of alpha-GPDG. One third of IAM patients demonstrated protracted variant of the disease course by a study into the bioenergetic status of blood lymphocytes. Examination of parameters of blood lymphocytes energy exchange permits establishing more differential and diagnostic criteria for inflammatory lesion of the myocardium.

[Late ventricular potentials, ventricular arrhythmias and sudden death in patients with acquired heart defects]. / Pozdnie potentsialy zheludochkov, zheludochkovye aritmii i vnezapnaia smert' u bol'nykh s priobretennymi porokami serdtsa.

Late ventricular potentials (LVP) were registered in patients with acquired valvular disease and compared to the data obtained at 24-h ECG monitoring, echocardiography and prospective 1.5-2-year follow-up. LVP were found in 14.8% of the examinees, being most frequent in patients with predominant failure of mitral or aortic valve, less frequent in those with aortic ostial stenosis and absent in patients with mitral stenosis. In LVP patients cardiomegaly, lowered myocardial contractility, high-grade ventricular extrasystole occurred more frequently. LVP measurement appeared a sensitive and specific prognostic method in respect to sudden death.

[Coenzyme metabolic therapy in infectious allergic myocarditis]. / Kofermentnaia metabolicheskaia terapiia pri infektsionno-allergicheskom miokardite.

A trial was performed of clinical efficacy of the coenzyme complex incorporating piridoxalphosphate, cobamamide and phosphaden in patients with infectious allergic myocarditis. Myo- cardial dystrophy and correlations of the myocardial enzymatic status with blood lymphocytes in the above patients were taken in consideration. Corrective action of metabolic therapy on myocardial bioenergy was coupled with positive antiarrhythmic and cardiotonic effects. Cytochemical follow-up investigations enabled long-term monitoring over the patients' condition and further catamnesis.

[The cytochemical characteristics of the blood polymorphonuclear leukocytes in dilated cardiomyopathy and an inflammatory myocardial lesion]. / Tsitokhimicheskaia kharakteristika polimorfnoiadernykh leikotsitov krovi pri dilatsionnoi kardiomiopatii i vospalitel'nom porazhenii miokarda.

Using methods of cytochemical investigation of the blood polymorphonuclear leucocytes (PMNL), parameters have been studied, characterizing the systems of biological defence and bioenergetics in patients with dilated cardiomyopathy (DCMP), infectious allergic myocarditis (IAM) and myocarditic cardiosclerosis (MCS). DCMP patients showed depression of NBT--test against the background of the increase in the cationic proteins (CP) level in the blood PMNLs, which was a major cytochemical feature. G-6-PhDG activity was increased in IAM patients against the background of high values of NBT-test. Increased values for G-6-PhDG, CP, phosphatases in the presence of low levels of myeloperoxidase in the blood PMNL suggest chronic inflammatory process in the myocardium. Investigation into the cytochemical parameters of bioenergetic and biological defence of the blood PMNL in patients with DCMP, IAM and MCS permits optimization of the diagnosis and treatment policy in the aforementioned nosological entities.

[The characteristics of the psychological status of myocardial infarct patients and geomagnetic factors]. / Osobennosti psikhologicheskogo statusa bol'nykh infarktom miokarda i geomagnitnye faktory.

An analysis is presented of myocardial infarction (MI) incidence during a 366-day period. Results were compared with prognostic and real unfavourable days by geomagnetic values (data of the Geophysical Institute in Göttingen (Germany)). There was no essential morbidity rise in the unfavourable days but a greater number of IM was noted during coincidence of prognostic and real unfavourable days. Among the patients persons with a definite psychological background prevailed. It is suggested that a greater sensitivity to geomagnetic factors is acquired during psychological and physical readaptation reflecting destabilization of the regulatory systems of the human body.

[The metabolic characteristics of the blood leukocytes in infectious-allergic myocarditis and dilated cardiomyopathy]. / Metabolicheskie osobennosti leikotsitov krovi pri infektsionno-allergicheskom miokardite i dilatatsionnoi kardiomiopatii.

41 patients with dilated cardiomyopathy (DCMP), 62 patients with infectious allergic myocarditis (IAMC) and 36 patients with myocarditis cardiosclerosis (MCCS) were examined cytochemically. This involved assessment of the activity of alpha-glycerophosphate- and glucose 6-phosphate dehydrogenases, nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate diaphorases, NBT test parameters, measurements of endogenic cytochrome C and cation protein, activity of acid and alkaline phosphatase, lymphocyte peroxidase and that in peripheral blood polymorphonuclear leukocytes. The findings of the study confirmed a close functional and metabolic relation of the above cytochemical indices. This allows their introduction as additional laboratory criteria in differential diagnosis of inflammatory and idiopathic myocardial affections.

[Echocardiographic assessment of cardiac pump function using afterloading characteristics]. / Ekokardiograficheskaia otsenka nasosnoi funktsii serdtsa s pomoshch'iu postnagruzochnykh kharakteristik.

Seventy five patients and twenty healthy individuals were investigated by using cardiac ultrasound technique, followed by mathematical simulation of changes in left ventricular pressure during contraction. The findings show that the afterload characteristics based on a wealth of evidence for cardiac and left ventricular performance, unlike the conventional central hemodynamic parameters and cardiac phasic indices, enable the occult circulatory disorders to be revealed and the cardiac compliance with the arterial system to be assessed.

[The indices of the proteinase-peroxidase and phosphatase activities of the blood polymorphonuclear leukocytes in the differential diagnosis of dilated cardiomyopathy and idiopathic myocarditis]. / Pokazateli proteinazno-peroksidaznoi i fosfataznoi aktivnosti polimorfno-iadernykh leikotsitov krovi v differential'noi diagnostike dilatatsionnoi kardiomiopatii i idiopaticheskogo miokardita.

The indices of cytochemical activity of the proteinase-peroxidase system and phosphatases of polymorphous-nuclear leucocytes were studied in patients with dilated cardiomyopathy and idiopathic myocarditis. It was found that patients with dilated cardiomyopathy showed an increased level of cationic proteins in polymorphous-nuclear leucocytes while an increase of alkaline phosphatase activity and acid phosphatase against the background of reduction of the cationic protein level and peroxidase activity was characteristic of idiopathic myocarditis. The obtained data allow to use the above cytochemical parameters in the differential diagnosis of noncoronarogenic lesions of the myocardium.

[Cytochemical parameters of lymphocytes in non-coronarogenic myocardial diseases]. / Tsitokhimicheskie parametry limfotsitov krovi pri nekoronaro- gennykh zabolevaniiakh miokarda.

Blood lymphocyte redox enzymes were examined in 102 patients with infectious allergic myocarditis and vegetative dyshormonal +myocardial dystrophy. Dehydrogenase activity was found shifted and cellular energy balance disordered, these factors being valuable for differential diagnosis. Estimation of the lymphocytic energy plastic coefficient permits a dynamic monitoring of patient's status and helps predict the outcome of rehabilitation process. The detected metabolic shifts prompted inclusion of ++pyridoxal phosphate, a new coenzymic drug, in complex of treatment of this patient population.

[The efficacy of the coenzyme treatment of patients with idiopathic myocarditis]. / Effektivnost' lecheniia kofermentami bol'nykh idiopaticheskim miokarditom.

The authors analyze treatment results of a coenzyme complex (pyridoxalphosphate, cobalamide, phosphaden) in patients with idiopathic myocarditis. This complex produced a corrective effect on the energy processes in the myocardium. Analysis of correlative metabolic changes in blood neutrophils enables the possibility of dynamic control of the efficacy of drug treatment.

[Comparative characteristics of the arrhythmic syndrome and the possibility for its coenzyme correction in dilated and hypertrophic cardiomyopathy]. / Sravnitel'naia kharakteristika aritmicheskogo sindroma i vozmozhnosti ego kofermentnoi korrektsii pri dilatatsionnoi i gipertroficheskoi kardiomiopatiiakh.

Disorders of heart rhythm and conduction were characterized clinically and by electrocardiography in 82 patients with dilated and hypertrophic cardiomyopathies. Based on an analysis of blood lymphocyte cytochemistry energy-deficient conditions of the myocardium were identified in the patients examined. In order to correct the metabolic shifts in the myocardium, use was made of a coenzymic medicamentous complex including pyridoxalphosphate, cobamamide and phosphadene. The complex indicated was shown to potentiate the action of antiarrhythmic agents employed in the treatment of idiopathic cardiomyopathies.