RESUMO
Myo-inositol (MI) and its isomers are used for the treatment of various neuropathological conditions. The purpose of the present research was to study anticonvulsant properties of MI and scyllo-inositol (SCI) on pentylenetetrazol (PTZ) induced seizures in rats. Half an hour after treatment with MI (30 mg/kg) or SCI (5 mg/kg) seizures were induced in Wistar rats with PTZ (60 mg/kg). Control animals were treated either by normal saline or mannitol (control polyol of the same molecular weight, 30 mg/kg), given at the same time interval before PTZ injection, as MI/SCI groups. The anticonvulsant effects of MI/SCI treatment were assessed by the latent period (the time from PTZ-injection to the onset of first seizures), and the duration and severity (score) of seizures. The mortality rate was also assessed. Both MI and SCI treatment significantly reduced the seizure score, seizure duration and increased the latent period. These data suggest for strong potential of MI and SCI as the agents of antiepileptic therapy.
Assuntos
Anticonvulsivantes/farmacologia , Inositol/farmacologia , Convulsões/tratamento farmacológico , Animais , Convulsivantes/toxicidade , Pentilenotetrazol/toxicidade , Ratos , Ratos Wistar , Convulsões/induzido quimicamenteRESUMO
Quantitative study of GABAergic and main cells in the hippocampus and piriform cortex of Krushinskii-Molodkina rats was performed 1 month after the incidence of seizure activity evoked by acoustic stimulation. The number of neurons significantly decreased in both regions and, particularly, in the hippocampus and central area of the piriform cortex.
Assuntos
Estimulação Acústica , Sistema Límbico/fisiologia , Neurônios/fisiologia , Ácido gama-Aminobutírico/metabolismo , Estimulação Acústica/efeitos adversos , Estimulação Acústica/veterinária , Animais , Contagem de Células , Interneurônios/citologia , Interneurônios/fisiologia , Sistema Límbico/metabolismo , Neurônios/citologia , Neurônios/metabolismo , Ratos , Ratos Endogâmicos , Convulsões/etiologia , Fatores de TempoRESUMO
Oleamide exhibits antiepileptic activity and significantly decreases the degree of pentylenetetrazole-induced seizures.
Assuntos
Anticonvulsivantes/uso terapêutico , Hipnóticos e Sedativos/uso terapêutico , Ácidos Oleicos/uso terapêutico , Pentilenotetrazol/efeitos adversos , Convulsões/induzido quimicamente , Convulsões/tratamento farmacológico , Animais , Ratos , Convulsões/mortalidadeRESUMO
We studied the effect of myo-inositol on pentylenetetrazole and kainic acid-induced seizures in rats. Myo-inositol significantly reduced seizure activity.
Assuntos
Anticonvulsivantes/farmacologia , Inositol/farmacologia , Ácido Caínico , Pentilenotetrazol , Convulsões/tratamento farmacológico , Animais , Anticonvulsivantes/uso terapêutico , Convulsivantes , Inositol/uso terapêutico , Ratos , Convulsões/induzido quimicamenteRESUMO
GABAergic neurons in different fields of the hippocampus and pyriform cortex were examined 2 weeks and 1 month after electric stimulation of the ventral hippocampus. The counts of GABAergic neurons in the studied structures decreased significantly. The most pronounced shifts in the pyriform cortex were found in the central compartment. Decreased number of inhibitory elements in the two major epileptogenic structures attests to appreciable restructuring in the functions of their neuronal circles.