RESUMO
ABSTRACT: We describe hitherto unreported physiological low-grade 68Ga-PSMA-11 uptake in dural sinuses of patients who underwent 68Ga-PSMA-11 PET/CT for evaluation of prostate carcinoma. A strong positive correlation was found between SUVmax of tracer uptake in dural sinuses and SUVmax of blood pool activity in superior vena cava. Low-grade 68Ga-PSMA-11 uptake seen in dural sinuses is physiological and is most likely result of venous blood pool activity. Such uptake should not be interpreted as pathological. Knowledge of such physiological uptake is essential for optimal interpretation of PSMA PET/CT images and differentiating physiological versus pathological uptake.
Assuntos
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Neoplasias da Próstata , Masculino , Humanos , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Veia Cava Superior , Ácido Edético , Oligopeptídeos , Estudos Retrospectivos , Radioisótopos de Gálio , Neoplasias da Próstata/diagnóstico por imagem , Neoplasias da Próstata/patologiaRESUMO
We present fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) findings in an extremely rare case of penile metastasis from renal cell carcinoma. A 66-year-old male, a known case of renal cell carcinoma, underwent FDG PET-CT. The scan showed metabolically active cervical lymph nodes, lytic skeletal lesions, deposit in the left adrenal gland, and nodules in the bilateral lungs, indicating metastatic disease. In addition, a hypermetabolic lesion was seen in the corpus cavernosum of the shaft of the penis, suggestive of penile metastasis. Follow-up PET-CT after tyrosine kinase inhibitor therapy showed reduction in size and metabolic activity of all previously seen lesions including penile lesion, suggestive of favorable response to therapy.
RESUMO
A 67-year-old man with no previous history of malignancy presented with trigeminal neuralgia. MRI of the brain revealed extra-axial lesion along right trigeminal nerve suggestive of neuroma. On histopathology, the lesion was found to be metastasis from adenocarcinoma prostate. Patient underwent Ga-prostate-specific membrane antigen PET/CT for assessing the whole-body status of the disease, which revealed primary prostate lesion, metastatic bone lesions, and extra-axial lesion along the right trigeminal nerve. Extra-axial, intracranial metastasis from prostate carcinoma is an uncommon phenomenon. We describe Ga-prostate-specific membrane antigen PET/CT findings in an exceedingly rare case of extra-axial metastatic lesion from prostate carcinoma.