RESUMO
We evaluated the effect of hippocampal injection of lentiviral particles p156-CMV-EGFP on behavior, learning, and microglial Iba1(+) cells activation in mice. Testing in the open field and elevated plus-maze revealed higher anxiety levels in lentiviral-injected mice in comparison with animals injected with vehicle. At the same time, lentivirus injection did not change learning and memory of mice in the hippocampal-dependent fear conditioning task. Microglia density in lentivirus-injected mice was significantly higher than in vehicle-injected mice. Thus, hippocampal injection of lentiviral particles with minimum content of transgenes produced evident inflammation process, changed anxiety level of experimental animals, but had no effect on hippocampal-dependent learning and memory.
Assuntos
Região CA1 Hipocampal/virologia , Giro Denteado/virologia , Lentivirus/imunologia , Neurônios/virologia , Transdução Genética , Animais , Região CA1 Hipocampal/imunologia , Cognição , Giro Denteado/imunologia , Lentivirus/genética , Masculino , Aprendizagem em Labirinto , Camundongos Endogâmicos C57BL , Neurônios/imunologiaAssuntos
Neoplasias da Mama , Complicações Neoplásicas na Gravidez , Adenofibroma/diagnóstico , Adenofibroma/terapia , Adenoma/diagnóstico , Adenoma/terapia , Adulto , Doenças Mamárias/diagnóstico , Doenças Mamárias/terapia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/terapia , Cistos/diagnóstico , Cistos/terapia , Feminino , Humanos , Lactação , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico , Complicações Neoplásicas na Gravidez/terapiaRESUMO
Application of a sampling-dynamic procedure for evaluation of the immunologic vigor of breast cancer patients established certain differences in the individual patient indexes in a clinically uniform study group before treatment. All members of the study group received similar treatment which produced identical end results. The "immunologic profile" obtained by means of a study of parameter interrelationship was found to differ significantly in patients who had a favorable and unfavorable course within 2 years post-treatment. A prognostic table for selection of the most likely candidates for tumor dissemination and recurrence development is presented.
Assuntos
Neoplasias da Mama/imunologia , Adulto , Linfócitos B/imunologia , Neoplasias da Mama/patologia , Feminino , Humanos , Contagem de Leucócitos , Pessoa de Meia-Idade , Metástase Neoplásica , Estadiamento de Neoplasias , Prognóstico , Análise de Regressão , Formação de Roseta , Estudos de Amostragem , Linfócitos T/imunologia , Fatores de TempoRESUMO
Carcinoma of the stomach was revealed in 34,4% of patients with continuous gastric disorders. Early carcinoma was found only in 10% of them. The authors believe that the measures aimed at the detection of early forms of carcinoma should be taken in the group of an increased oncological risk. The conservative treatment of patients with gastric ulcer should be preceded by endoscopy with verification. The indications for the surgical treatment of the ulcer must be determined before the development of complications.