[Magnesium and vitamin B2 status of children with bronchial asthma and obesity].

Insufficiency or deficiency of some micronutrients may be additional modifying factors that influence the pathogenesis of the disease and the effectiveness of standard pharmacotherapy. The aim of the study - to evaluate the level of magnesium and vitamin B2 in blood serum of patients with bronchial asthma and obesity in order to develop methods for individual correction of deficiency. Material and methods. The study included 51 children aged 12-17 years. The first group included 23 patients (12 girls and 11 boys) with asthma with comorbidities (obesity), and the second group consisted of 28 children (10 girls and 18 boys) with obesity. The concentration of magnesium in blood serum was determined by a colorimetric method without deproteinization, and vitamin B2 - by an immunological microbiological method. Results and discussion. When analyzing the concentration of magnesium in blood serum of the examined children, it was found that in patients with bronchial asthma and obesity, a reduced content of this mineral was observed in 15 (65.2%) patients. The average magnesium concentration was 0.66±0.02 mmol/l at a rate of 0.7-1.2 mmol/l. A statistically significant decrease in the magnesium level in children suffering from asthma and obesity was noted, compared with the level in children with obesity (0.66 [0.57; 0.73] vs 0.71 [0.67; 0.73] mmol/l, р<0.05). Low serum magnesium levels in obese patients were detected more rarely (р<0.05) - only in 6 (21.4%) children, mostly in patients with grade III obesity. The remaining 22 (78.6%) children had magnesium level within the normal range. Patients with low serum magnesium levels showed increased irritability, sleep disturbance, loss of memory and concentration. Vitamin B2 levels in all examined children were within the normal range (137-370 ng/ml). Conclusion. The results indicate a decrease in the concentration of magnesium and normal levels of vitamin B2 in serum in patients with bronchial asthma and obesity. Low serum magnesium levels were observed in children with low bronchial asthma control. To increase the effectiveness of therapy and control the symptoms of bronchial asthma, especially when combined with obesity, correction of the accompanying magnesium deficiency is necessary.

[Alternative food for рatients with allergу to the egg].

Patients suffering from food allergy/food intolerance of eggs need alternative products that do not cause allergic reactions. The purpose of the research: to evaluate guinea fowl egg and meat tolerance among children with chicken egg allergy. There has been conducted single-centre prospective research into intolerance of the products. Appearance or increase in skin or gastrointestinal allergic symptoms was registered; the concentration of specific IgE antibodies against chicken egg and meat in blood serum was assessed. As alternative products, the children were offered guinea fowl egg and meat; these products were given to them during 14 days. In the research 40 children (23 girls and 17 boys) from the age of 8 months to 1.5 years old took part; all children were diagnosed with atopic dermatitis, one of its triggers was chicken egg. Exacerbation of skin allergy was connected with eating chicken egg, which was confirmed by the results of the allergy examination. 28 (70.0%) children were diagnosed as having the mild form of atomic dermatitis, while 12 (30.0%) patients had the moderate form of atomic dermatitis. At the beginning of the research the patients were divided into 2 equal groups (each group of 20 patients). The first group consisted of the children aged 8 moths - 1.5 years old who received 1/2 guinea fowl egg every other day. The second group consisted of the patients aged 1.5-3 years old who received 60-90 grams fowl egg meat per day. The research has revealed that the children showed tolerance of guinea fowl egg and meat, the majority of the patients did not experience any skin or gastrointestinal allergic reactions. It has also been shown that at the end of the research the majority of the children (73.3%) had a decrease in concentration of specific IgE antibodies against chicken egg and meat in blood serum. According to the allergy examination, 8 (26.7%) children experienced an increase in skin sensitization to chicken egg and meat, which coincided with exacerbation of skin allergy. Thus, the examined products can be used as alternative products for those children who suffer from food allergy/food intolerance of chicken egg and meat.

[Phenotypes of food allergy in children].

Questions of food allergy heterogeneity, approaches to allocation of various phenotypes on the basis of clinical signs and immunological markers taking into account an etiology and immune mechanisms of the disease are considered in the article. Allocation of phenotypes contributes the best understanding of essence and it expedient for development of individual approach to diet and therapy.