RESUMO
Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are recognized, although currently only a single complete genomic sequence corresponding to MCV subtype 1 is available. Using next-generation sequencing techniques, we report the complete genomic sequence of four new MCV isolates, including the first one derived from a subtype 2. Comparisons suggest a relatively distant evolutionary split between both MCV subtypes. Further, our data illustrate concurrent circulation of distinct viruses within a population and reveal the existence of recombination events among them. These results help identify a set of MCV genes with potentially relevant roles in molluscum contagiosum epidemiology and pathogenesis.
Assuntos
Genoma Viral , Vírus do Molusco Contagioso/classificação , Vírus do Molusco Contagioso/genética , Recombinação Genética , Criança , Análise por Conglomerados , Voluntários Saudáveis , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Vírus do Molusco Contagioso/crescimento & desenvolvimento , Vírus do Molusco Contagioso/isolamento & purificação , Filogenia , Análise de Sequência de DNA , Homologia de SequênciaRESUMO
A girl with multiple lesions of nevoid hypertrichosis and linear hypopigmentation following Blaschko's lines is presented. She had no extracutaneous anomalies. We hypothesize that this unusual coexistence of skin lesions may represent a further example of "twin spotting".