Parallel Multimodal Circuits Control an Innate Foraging Behavior.

Foraging strategies emerge from genetically encoded programs that are similar across animal species. Here, we examine circuits that control a conserved foraging state, local search behavior after food removal, in Caenorhabditis elegans. We show that local search is triggered by two parallel groups of chemosensory and mechanosensory glutamatergic neurons that detect food-related cues. Each group of sensory neurons suppresses distinct integrating neurons through a G protein-coupled metabotropic glutamate receptor, MGL-1, to release local search. The chemosensory and mechanosensory modules are separate and redundant; glutamate release from either module can drive the full behavior. A transition from local search to global search over several minutes after food removal is associated with two changes in circuit function. First, the spontaneous activity of sensory neurons falls. Second, the motor pattern generator for local search becomes less responsive to sensory input. This multimodal, distributed short-term food memory provides robust control of an innate behavior.

Influencia de parámetros de diseño sobre el comportamiento biomecánico de un implante dental corto / Influence of design parameters on the biomechanical behavior of a short dental implant

Introducción: Los implantes dentales deben transmitir esfuerzos al tejido óseo y generar deformaciones que favorezcan el equilibrio entre los procesos de formación y reabsorción ósea. Debido al alto número de pacientes que presentan maxilares con dimensiones reducidas, es necesario estudiar el comportamiento biomecánico de implantes dentales cortos. Objetivos: Evaluar el efecto de los parámetros de diseño: diámetro máximo, longitud de la interfaz hueso-implante y altura del filete de la rosca sobre el comportamiento biomecánico de un nuevo diseño de implante dental corto. Métodos: Los modelos tridimensionales del implante dental corto fueron creados usando el software Autodesk Inventor Profesional versión 2011 (Autodesk Inc, California, USA) y analizados con el software de elementos finitos Autodesk® Algor® Simulation (Autodesk Inc, California, USA). Resultados: Los niveles máximos de esfuerzos equivalentes de von Mises se obtuvieron, en el hueso cortical peri-implantar. Las cargas aplicadas al implante generaron, en el hueso trabecular peri-implantar, los mayores esfuerzos equivalentes de von Mises en la región apical y los menores valores en la región próxima al hueso cortical. Además, los mayores valores de deformación se obtuvieron en el hueso trabecular para todos los modelos estudiados. Conclusiones: En general, los resultados de las simulaciones mostraron que la mayoría de los modelos estudiados generan esfuerzos y deformaciones en el hueso cortical peri-implantar en niveles que estimulan el crecimiento y la remodelación ósea. No obstante, en algunas de las variantes simuladas se observaron niveles de esfuerzos y deformaciones, en zonas del hueso trabecular peri-implantar, que pueden provocar pérdida ósea en los maxilares. Las variables diámetro del implante y altura del filete de la rosca exhibieron la mayor influencia sobre los esfuerzos y deformaciones máximas generados en el tejido óseo(AU)

Introduction: Dental implants should transmit stresses to the bone tissue and generate strain levels that favor the balance between the bone formation and bone resorption processes. Due to the high number of patients with reduced jawbone dimensions, it is essential to study the biomechanical behavior of short dental implants. Objective: Evaluate the effect of the design parameters: Maximum diameter, Length of the bone-implant interface and Thread depth on the biomechanical behavior of a new design of short dental implant. Methods: The 3D models of the short dental implant were created using Autodesk Inventor Professional software (Autodesk Inc, California, USA) and analyzed by finite elements with Autodesk® Algor® Simulation software (Autodesk Inc, California, USA). Results: The maximum von Mises equivalent stress was obtained in peri-implant cortical bone. The loads applied to the implant generated in peri-implant cancellous bone, the highest von Mises equivalent stress in the lower end of the apical region and the lowest stress values in the region next to the cortical bone. In addition, the highest strain values were obtained in cancellous bone for all models under study. Conclusions: In general, the simulation results showed that most of the models under study generate stresses and strains in peri-implant cortical bone at levels that stimulate bone growth and bone remodeling. However, for some models, it was observed levels of stress and strain in peri-implant cancellous bone that could provoke the bone onset. The variables Implant diameter and Thread depth exhibited the greatest influence on the maximum stresses and strains obtained in the bone tissue(AU)

Clonal production and organization of inhibitory interneurons in the neocortex.

The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits. In contrast, relatively little is known about the production and organization of neocortical inhibitory interneurons. We found that neocortical inhibitory interneurons were produced as spatially organized clonal units in the developing ventral telencephalon. Furthermore, clonally related interneurons did not randomly disperse but formed spatially isolated clusters in the neocortex. Individual clonal clusters consisting of interneurons expressing the same or distinct neurochemical markers exhibited clear vertical or horizontal organization. These results suggest that the lineage relationship plays a pivotal role in the organization of inhibitory interneurons in the neocortex.