RESUMO
BACKGROUND: This case series of 5 patients with severely necrotic mpox highlights the predominantly necrotic nature of lesions seen in cases of severe mpox as shown by skin and lung biopsy, as well as the extensive dissemination of the infection, as shown by polymerase chain reaction (PCR) assessment in different body sites. CASE PRESENTATIONS: Patients were male, the median age was 37, all lived with HIV (2 previously undiagnosed), the median CD4+ cell count was 106 cells/mm3, and 2/5 were not receiving antiretroviral treatment. The most common complication was soft tissue infection. Skin and lung biopsies showed extensive areas of necrosis. Mpox PCR was positive in various sites, including skin, urine, serum, and cerebrospinal fluid. The initiation of antiretroviral treatment, worsened the disease, like that seen in immune reconstitution syndrome. Three patients died due to multiple organ failure, presumably associated with mpox since coinfections and opportunistic pathogens were ruled out. CONCLUSIONS: Severely necrotic manifestations of mpox in people living with advanced and untreated HIV are related to adverse outcomes.
Assuntos
Infecções por HIV , Mpox , Humanos , Masculino , Adulto , Feminino , Infecções por HIV/complicações , Infecções por HIV/tratamento farmacológico , Mpox/complicações , Mpox/tratamento farmacológico , Antirretrovirais/uso terapêutico , Contagem de Linfócito CD4 , Necrose/induzido quimicamente , Necrose/complicações , Necrose/tratamento farmacológicoRESUMO
Introduction: Keratoacanthoma (KA) is a group of tumors of epidermal origin with controversial nature. Subungual keratoacanthoma (SUKA) is a rare and destructive variant with more aggressive behavior. SUKA appears as a rapidly growing, painful tumor beneath the nail plate that rapidly progresses to a mass that can measure up to 2 cm. The toe location is unusual. The diagnosis must be made based on the correlation of clinical, radiological, and histopathological findings. Case Presentation: We present two cases of patients diagnosed with SUKAs with different clinical presentations which ranged from very typical to uncommon one. Both cases were treated with simple excision without recurrences. Conclusion: SUKA is a rare subungual tumor. Nail bed location represents a more difficult diagnostic challenge. SUKA should be suspected in the context of persistent and progressive pain on a finger or toe, once more frequent painful tumors have been ruled out.
RESUMO
Spontaneous pneumomediastinum (SP) is a clinical entity characterized by the presence of interstitial air in the mediastinum. The purpose of this study was to further examine a rare SP case in a 60-year-old male, with COVID-19. In conclusion, SP is an uncommon complication in COVID-19, and the recognition of clinical characteristics is crucial since early identification plays a significant role in the maintenance or recovery of the disease..(Au)
El neumomediastino espontáneo (NE) es una entidad clínica caracterizada por la presencia de aire intersticial en el mediastino. El propósito de este estudio fue examinar más a fondo un caso raro de NE en un hombre de 60 años con COVID-19. En conclusión, el NE es una complicación poco común de COVID-19 y el reconocimiento de las características clínicas es crucial, ya que su identificación temprana juega un papel importante en el mantenimiento y recuperación de la enfermedad..(Au)
