RESUMO
We report a case of disseminated infection by Rhodococcus equi as the inaugural manifestation of idiopathic T-CD4+ lymphopenia. We aim to demonstrate our diagnostic and therapeutic approach and focus on the major dilemmas arising from the lack of scientific evidence regarding best clinical practice of this infection in humans.
Assuntos
Infecções por Actinomycetales/microbiologia , Linfopenia/diagnóstico , Pneumonia Necrosante/diagnóstico , Rhodococcus equi/isolamento & purificação , Infecções por Actinomycetales/complicações , Infecções por Actinomycetales/diagnóstico , Infecções por Actinomycetales/patologia , Administração Intravenosa , Idoso , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Antibióticos Antituberculose/administração & dosagem , Antibióticos Antituberculose/uso terapêutico , Biópsia por Agulha/métodos , Lavagem Broncoalveolar/métodos , Broncoscopia/métodos , Linfócitos T CD4-Positivos , Tosse/diagnóstico , Tosse/etiologia , Quimioterapia Combinada , Serviço Hospitalar de Emergência , Febre/diagnóstico , Febre/etiologia , Humanos , Levofloxacino/administração & dosagem , Levofloxacino/uso terapêutico , Linfopenia/etiologia , Masculino , Pneumonia Necrosante/tratamento farmacológico , Pneumonia Necrosante/etiologia , Rifampina/administração & dosagem , Rifampina/uso terapêutico , Tomografia Computadorizada por Raios X/métodos , Resultado do TratamentoRESUMO
INTRODUCTION: Inflammatory changes are relatively frequent findings in cervical smears and are generally believed to be a consequence of genital infection. However, clinical signs of infection are frequently absent and no consensus exists on the management of these patients. The objective of this study was to assess whether or not inflammatory smears are exclusively a consequence of genital infection. For this purpose, the prevalence of genital infection in a group of women with inflammatory cells in the cervical smear and a control group with normal smears was compared. MATERIAL AND METHODS: Sixty-two regularly menstruating women aged 17 to 48 years, attending the outpatient Gynaecology sector of S. João Hospital, were prospectively evaluated. Cervical smears were analysed by the same cytologist who chose 10 inflammatory cells per high power field (400x) as the cut-off value for normality. Infection by Candida spp., Trichomonas vaginalis, Neisseria gonorrhoeae, Mycoplasma hominis, Ureaplasma urealyticum, Chlamydia trachomatis and bacterial vaginosis was investigated. Human Papillomavirus infection was evaluated by colposcopy and biopsy of abnormal colposcopic findings. RESULTS: Thirty-four women and inflammatory cells on their cervical smear and 15 of these (44%) had a genital infection. Of the 28 women with normal smears, 12 (43%) had a genital infection. No statistically significant difference in the prevalence of infection was found between the two groups. CONCLUSIONS: Our results suggest that the presence of inflammatory cells in cervical smears is not necessarily due to infection and other causes may be responsible for their appearance.