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Diagn Microbiol Infect Dis ; 105(2): 115866, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36525921

RESUMO

Burkholderia cepacia complex (Bcc) species are opportunistic pathogens widely distributed in the environment and often infect people with cystic fibrosis (CF). This study aims to determine which genomovars of the Bcc can cause infections in non-CF patients from a tertiary care hospital in Mexico and if they carry virulence factors that could increase their pathogenicity. We identified 23 clinical isolates that carry the recA gene. Twenty-two of them belongs to the genomovar V (B. vietnamiensis) and one to the genomovar II (B. multivorans). Thirteen pulsotypes were identified among 22 B. vietnamiensis isolates. All clinical isolates produced biofilm were motile and cytotoxic on murine macrophage-like RAW264.7 and in A549 human lung epithelial cells. In conclusion, B. vietnamiensis causes infections in non-CF patients in a tertiary care hospital in Mexico, rapid identification of this pathogen can help physicians to establish a better antimicrobial treatment.


Assuntos
Infecções por Burkholderia , Complexo Burkholderia cepacia , Burkholderia cepacia , Fibrose Cística , Humanos , Animais , Camundongos , Burkholderia cepacia/genética , Infecções por Burkholderia/epidemiologia , México/epidemiologia , Centros de Atenção Terciária , Reação em Cadeia da Polimerase , Complexo Burkholderia cepacia/genética , Fibrose Cística/complicações
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