Promoting scientific understanding and conceptual change in young children using explanations and guidance.

Evaluating evidence and restructuring beliefs based on anomalous evidence are fundamental aspects of scientific reasoning. These skills can be challenging for both children and adults, especially in domains where they possess inaccurate prior beliefs that can interfere with the acquisition of correct scientific information (e.g., heavier objects fall faster than light ones). Across two experiments, we examined the additive benefit of combining explanations with guided activities to promote conceptual change. In Experiment 1 (N = 238), 4- and 5-year-olds were randomly assigned to one of three conditions: guidance with explanations, guidance only, or baseline. The guided conditions varied only in the presence or absence of conceptual information (i.e., explanation about gravity). Pre- and posttest measures showed that children's predictions improved from both guided conditions compared to the baseline condition but did not significantly differ from each other. Experiment 2 (N = 80, 5-year-olds) included a delay test and assessed children's learning through the justification of their predictions. Although children's performance at the immediate posttest improved in both conditions, in the guidance only, children's performance returned to the pretest levels of understanding after the delay. Children in the guidance with explanations condition had greater understanding at posttest, retained this understanding long term, and transferred it to objects with the same weight. These findings highlight the role of explanations in aiding children's long-term learning from anomalous evidence in guided activities. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Considerations of Left Ventricular Assist Device Therapy in the United States' Prison System.

Left ventricular assist device therapy for advanced heart failure is contraindicated if a patient lives in an unsafe environment and recent guidelines declare that "legal history is pertinent for determining personal constraints or financial responsibilities due to parole requirements, pending charges, and possible imprisonment," implying that incarceration would be a contraindication. International guidelines and precedent in the United States establish that medical care for incarcerated persons should match access in the community. We present a case example and practical considerations for advanced heart failure programs faced with the challenge of partnering with patients with heart failure who may be incarcerated and their correctional health systems in the care of their chronic condition. We encourage the heart failure community to not let incarceration be a contraindication to left ventricular assist device therapy.

Frontal interhemispheric structural connectivity, attention, and executive function in children with perinatal stroke.

Perinatal stroke affects ∼1 in 1000 births and concomitant cognitive impairments are common but poorly understood. Rates of Attention Deficit/Hyperactivity Disorder (ADHD) are increased 5-10× and executive dysfunction can be disabling. We used diffusion imaging to investigate whether stroke-related differences in frontal white matter (WM) relate to cognitive impairments. Anterior forceps were isolated using tractography and sampled along the tract. Resulting metrics quantified frontal WM microstructure. Associations between WM metrics and parent ratings of ADHD symptoms (ADHD-5 rating scale) and executive functioning (Behavior Rating Inventory of Executive Function (BRIEF)) were explored. Eighty-three children were recruited (arterial ischemic stroke [AIS] n = 26; periventricular venous infarction [PVI] n = 26; controls n = 31). WM metrics were altered for stroke groups compared to controls. Along-tract analyses showed differences in WM metrics in areas approximating the lesion as well as more remote differences at midline and in the nonlesioned hemisphere. WM metrics correlated with parental ratings of ADHD and executive function such that higher diffusivity values were associated with poorer function. These findings suggest that underlying microstructure of frontal white matter quantified via tractography may provide a relevant biomarker associated with cognition and behavior in children with perinatal stroke.

The Role of Alternative Theories and Anomalous Evidence in Children's Scientific Belief Revision.

Children's naive theories include misconceptions which can interfere with science learning. This research examined the effect of pairing anomalies with alternative theories, and their order of presentation, on children's belief revision. Children believe that heavy objects sink and light ones float. In a pre-, mid-, and post-test design, 5-year-olds (N = 96) were assigned to one of two conditions, where they were either exposed to an alternative theory about buoyancy and then observed anomalies (Explanation-First), or the reverse (Anomalies-First). At mid-test, children were more likely to revise their beliefs after exposure to an alternative theory than anomalies alone. At post-test, children revised their naïve belief when they had access to an alternative theory before the anomalous evidence than in the opposite order.

Prompting Children's Belief Revision About Balance Through Primary and Secondary Sources of Evidence.

Prior evidence has shown that children's understanding of balance proceeds through stages. Children go from a stage where they lack a consistent theory (No Theory), to becoming Center Theorists at around age 6 (believing that all objects balance in their geometric center), to Mass Theorists at around age 8, when they begin to consider the distribution of objects' mass. In this study we adapted prior testing paradigms to examine 5-year-olds' understanding of balance and compared children's learning about balance from evidence presented through primary sources (a guided activity) or secondary sources (picture books). Most of the research on young children's understanding of balance has been conducted using a single object, weighted either proportionally (symmetrical object) or disproportionally (asymmetrical object). In this study, instead of using a single object, 5-year-olds (N = 102) were shown 4 pairs of objects, two with the same weight and two with different weight. Children were told to place the objects on a beam where they thought they would balance. We found evidence for an intermediate level of understanding. Transition Theorists represent children who have two distinct theories, one for balancing same weight objects, and one for balancing different weight objects, but one of these theories is incorrect. Following the assessment of children's understanding, we compared their learning about balance from evidence that was either presented through primary sources (a guided activity) or secondary sources (picture books). Children learn equally well from both sources of evidence. Findings are discussed in terms of theoretical and practical implications.

Do storybooks with anthropomorphized animal characters promote prosocial behaviors in young children?

For millennia, adults have told children stories not only to entertain but also to impart important moral lessons to promote prosocial behaviors. Many such stories contain anthropomorphized animals because it is believed that children learn from anthropomorphic stories as effectively, if not better than, from stories with human characters, and thus are more inclined to act according to the moral lessons of the stories. Here we experimentally tested this belief by reading preschoolers a sharing story with either human characters or anthropomorphized animal characters. Reading the human story significantly increased preschoolers' altruistic giving but reading the anthropomorphic story or a control story decreased it. Thus, contrary to the common belief, realistic stories, not anthropomorphic ones, are better for promoting young children's prosocial behavior.

Life-threatening dermatologic adverse events in oncology.

The incidences of life-threatening toxicities such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are inconsistently reported. The potential association of anticancer agents with SJS or TEN has not been systematically investigated. We searched the literature (Ovid: 1950 to June 2013 and PubMed: 1948 to June 2013) using terms for SJS/TEN and anticancer therapies. Primary case reports, case series, and clinical trials were included. In addition, MedWatch, the Food and Drug Administration Adverse Event Reporting System (FAERS), was searched (1968 to August 2012) for SJS/TEN reports associated with anticancer therapies. Proportional reporting ratios (PRR>2, N>3), empirical Bayes geometric mean (EBGM>2, N>3), and lower 95% confidence interval (EBGM0.05>2) were used as thresholds to constitute a signal of association between SJS/TEN and anticancer drugs. There were 46 SJS and 37 TEN cases associated with 18 and 22 anticancer drugs in the literature, respectively. Among cases in the FAERS, significant signals were associated with SJS for bendamustine and with TEN for bendamustine, busulfan, chlorambucil, fludarabine, lomustine, and procarbazine. Several drugs reported in the published literature to be associated with SJS/TEN were not found to have significant signals in FAERS. Proactive pharmacovigilance to detect and define safety signals serves to aid oncology practitioners in the recognition of possible, yet uncommon, serious, and/or life-threatening skin reactions.