Menthol concentration in topical cold gel does not have significant effect on skin cooling.

BACKGROUND: Topical menthol gels are used in the treatment of various pain conditions. However, the effect of the menthol concentration to skin cooling or cooling sensation is not clear. We hypothesized that increasing menthol concentration enhances skin cooling and causes elevated cooling sensation. METHODS: Ten healthy male volunteers (age range 25-30 years) were recruited for this study. Application of three gels with different menthol concentrations (0.5%, 4.6% and 10.0%) was tested in random sequence on the left thigh of the subjects. Skin cooling was recorded with a digital infrared camera (FLIR Systems Inc., USA), and cooling sensation was measured with the visual analogue scale rating. RESULTS: All gels decreased skin temperature significantly (P < 0.05) at least for one hour. However, the variation in menthol concentration seemed not to have a significant effect on skin cooling. Subjects experienced that gel with 4.6% menthol concentration caused significantly stronger cooling effect than 0.5% and 10.0% gels. Gel application had no significant effect on skin temperature in surrounding skin areas. CONCLUSION: In contrast to our hypothesis, menthol concentration was not connected to skin cooling, while moderate menthol concentration of 4.6% may induce stronger cooling sensation compared to low (0.5%) or high (10.0%) concentration gels.

Thermal imaging in screening of joint inflammation and rheumatoid arthritis in children.

Potential of modern thermal imaging for screening and differentiation of joint inflammation has not been assessed in child and juvenile patient populations, typically demanding groups in diagnostics of musculoskeletal disorders. We hypothesize that thermal imaging can detect joint inflammation in patients with juvenile idiopathic arthritis or autoimmune disease with arthritis such as systemic lupus erythematosus. To evaluate the hypothesis, we studied 58 children exhibiting symptoms of joint inflammation. First, the patients' joints were examined along clinical procedure supplemented with ultrasound imaging when deemed necessary by the clinician. Second, thermal images were acquired from patients' knees and ankles. Results of thermal imaging were compared to clinical evaluations in knee and ankle. The temperatures were significantly (pmax = 0.044, pmean < 0.001) higher in inflamed ankle joints, but not in inflamed knee joints. No significant difference was found between the skin surface temperatures of medial and lateral aspects of ankle joints. In knee joints the mean temperatures of medial and lateral aspect differed significantly (p = 0.004). We have demonstrated that thermal imaging may have potential for detecting joint inflammation in ankle joints of children. For knee joints our results are inconclusive and further research is warranted.