RESUMO
BACKGROUND: Multidisciplinary interventions for fallers have provided conflicting results in part due to the diversity of fallers' profiles. OBJECTIVES: to determine the characteristics of the subgroup of patients with a positive response to a multidisciplinary fall prevention program initiated in a geriatric day hospital. DESIGN: Prospective observational study in day hospital. METHODS: Patients > 75 years referred for falls during the last 3 months benefited from a multidisciplinary assessment to record their characteristics at baseline and to tailor a risk-based multidisciplinary intervention for fall prevention. Patients free from falls at the 3rd or 6th month were compared to persistent fallers for baseline characteristics. RESULTS: Sixty-nine patients were assessed at baseline (mean age 85.2 y (SD=0.6)), 44 at the 3rd month and 21 at the 6th month. Baseline characteristics of the patients free from falls at the 3rd month were the lower number of previous non-serious falls (p=0.013), living in nursing home (p=0.045), a higher Berg balance score (p=0.02) and a better mental health-related quality of life (M HQol, p=0.045). On multivariate analysis restricted to home-dwelling patients, the positive predictive factors were less isolation at home (OR=0.028, 95%CI [0-0.813], p=0.037), a lower number of non-serious previous falls (OR= 0.526 [0.309- 0.894], p=0.018), a better M HQol (OR=1.205 [1.000-1.452], p=0.050) and a trend for younger age (OR= 0.662, [0.426-1.027], p=0.066). CONCLUSION: Being able to call upon a support person (familial or institutional) to apply advice and a less serious risk of falling may be preliminary conditions for success in a multidisciplinary intervention initiated in a day hospital.
Assuntos
Prevenção de Acidentes , Acidentes por Quedas , Avaliação Geriátrica , Serviços de Saúde , Saúde Mental , Equipe de Assistência ao Paciente , Equilíbrio Postural , Acidentes por Quedas/prevenção & controle , Acidentes Domésticos , Fatores Etários , Idoso de 80 Anos ou mais , Hospital Dia , Feminino , Humanos , Masculino , Análise Multivariada , Casas de Saúde , Estudos Prospectivos , Qualidade de Vida , Recidiva , Fatores de Risco , Isolamento Social , Resultado do TratamentoRESUMO
The intestinal absorption and portal vein transport of Na octanoate by isolated jejunal segments perfused in vivo were unchanged in rats studied 48 h after bile duct ligation or fistula.
Assuntos
Bile/fisiologia , Fístula Biliar/metabolismo , Caprilatos/metabolismo , Colestase/metabolismo , Jejuno/metabolismo , Animais , Ducto Colédoco , Absorção Intestinal , Masculino , Veia Porta/fisiologia , Ratos , Fluxo Sanguíneo Regional , Sódio/metabolismo , Água/metabolismoRESUMO
The absence of bile from the intestinal lumen of rats for a period of 48 hr led to: a decreased proliferative cell pool, reduced cell shedding, and a 50% decrease of the labeling index in the ileum. The constant duodenal perfusion of Na taurocholate for periods of 48, 60, 72, and 96 hr in animals with a biliary diversion was associated with: deepening of crypts and decreased crypt/villus ratios as well as with acceleration of the epithelial cell migration rate on the crypt-villus units. The data suggest that bile and bile acids constitute important regulatory factors influencing enterocyte proliferation, migration and loss.