RESUMO
A new catalytic strategy for the one-pot synthesis of N-sulfonylamidines is described. The cationic copper(I) complexes were found to be highly active and efficient under mild conditions in air and in the absence of solvent. A copper acetylide is proposed as key intermediate in this transformation.
RESUMO
A straightforward method for the hydrophenoxylation of internal alkynes, using N-heterocyclic carbene-based copper(i) and gold(i) complexes, is described. The heterobimetallic catalytic system proceeds via dual activation of the substrates to afford the desired vinylether derivatives. This methodology is shown to be highly efficient and tolerates a wide range of substituted phenols and alkynes.
RESUMO
Homo- and heteroleptic bis-NHC copper(I) complexes have been efficiently used as carbene transfer reagents to Au and Pd. The simple and straightforward procedure allows for the synthesis of well-known gold complexes as well as novel cationic bis-NHC Pd(II) species.
RESUMO
The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper-NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than those of previously reported methods.
Assuntos
Amino Álcoois/química , Nitrilas/química , Compostos Organometálicos/química , Oxazóis/síntese química , Catálise , Cobre/química , Compostos Heterocíclicos/química , Metano/análogos & derivados , Metano/química , Estrutura Molecular , Oxazóis/químicaRESUMO
The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(i) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.
RESUMO
A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.
Assuntos
Cobre/química , Compostos Organometálicos/química , Paládio/química , Brometos/química , Catálise , Cloretos/químicaRESUMO
A recently isolated gold(I) complex, [Au(IPr)(OH)], permits the transformation of carboxylic acids to the corresponding decarboxylated gold(I)-aryl complex without the use of silver co-catalyst under mild reaction conditions.