VENOUS THROMBOEMBOLISM - PECULIARITIES OF COURSE IN EMERGENCY SURGERY DURING COVID-19 PANDEMIC.

OBJECTIVE: The aim: To perform a comparative analysis of VTE in patients with acute surgical abdominal pathology before and during the COVID-19 pandemic. PATIENTS AND METHODS: Materials and methods: Retrospective study covered 53062 patients operated in the surgical clinic (Lviv city emergency hospital) in 2000-2019. Prospective analysis was based on the results of treatment of 546 patients operated at the same surgical clinic from April 2020 (1st surgical patient with COVID-19) till December 2021. The study analyzed 48 (8.8%) patients operated for acute abdominal pathology and confirmed diagnosis of COVID-19. RESULTS: Results: In the 1st group, heparin prophylaxis was used in 42.3% of patients, of which non-fractionated heparin were used in 58.6% and low molecular weight heparin - in the remaining patients. From 2020 to 2021, pharmacoprophylaxis was used in 84.5% of cases, of which 67.2% - low molecular weight heparins, 20.1% - non-fractionated heparins and 12.7% - modern oral anticoagulants. The results were unexpected: with a significant increase in the ve¬nous thromboembolism prevention in the 2nd group, a decrease in the number of episodes of thromboembolic complications was not observed. In contrast, pulmonary artery embolism was recorded in 10.6% of patients in the 1st group and 23.5% - in 2nd group, which is a 2.2-fold increase in fatal cases of venous thrombosis (p<0.05) in patients with COVID-19. CONCLUSION: Conclusions: Increase of mortality due to pulmonary artery embolism more than twicefold in patients with COVID-19 operated for acute surgical abdominal pathology is an objective evidence of a potentiated, uncontrolled risk of venous thromboembolism and requires further in-depth study.

A Case of Rare Complication of Inguinal Parietoplasty according to Lichtenstein: Entero Cutaneous Fistula.

Lichtenstein intervention is currently the classic model of the regulated treatment of inguinal hernias by direct local approach. This "tension-free" technique satisfies both patients and practitioners. However, it does not often evade severe complications of parietal surgery. The authors report their treatment experience in rural Africa of a late enterocutaneous fistula which aggravated an inguinal hernia repair according to the Lichtenstein procedure. Physiopathology, diagnosis, and treatment of that disease are analyzed in the light of literature.

Spectral and lifetime domain measurements of rat brain tumors.

During glioblastoma surgery, delineation of the brain tumor margins is difficult because the infiltrated and normal tissues have the same visual appearance. We use a fiber-optical fluorescence probe for spectroscopic and time domain measurements to assist surgeon in differentiating the healthy and the infiltrated tissues. First study was performed on rats that were previously injected with tumorous cells. Measurements of endogenous tissue fluorescence were performed on fresh and fixed rat tumor brain slices. Spectral characteristics, fluorescence redox ratios and fluorescence lifetime measurements were analyzed. The study aimed at defining an optical index that can act as an indicator for discriminating healthy from tumorous tissue.