1.
Org Biomol Chem
; 19(21): 4701-4705, 2021 06 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33988213
RESUMO
A practical one-pot protocol has been developed to synthesize diarylacetylenes from arylaldehydes by treatment with 1-(arylmethyl)benzotriazoles and LiN(SiMe3)2. The reaction proceeded through imine formation, Mannich-type addition and double elimination to deliver products in up to 99% yields with broad substrate scope. In addition, gram-scale synthesis of 1-bromo-4-(phenylethynyl)benzene has been demonstrated.