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3.
Infection ; 46(5): 581-590, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29796739

RESUMO

PURPOSE: The global rise of multidrug resistant organisms (MDROs) is of major concern since infections by these pathogens are difficult, and in some cases, even impossible to treat. This review will discuss the effectiveness of a pathogen-independent alternative approach consisting of the implementation of antibiotic stewardship (ABS) programs, improvement of hand hygiene compliance, and daily antiseptic body washings instead of "screening, isolation and eradication" as recommended by many infection control guidelines today. METHODS: A review of the literature. RESULTS: The classical approach composed of screening, isolation and eradication has many limitations, including lack of standardization of the screening methods, risk of medical errors for patients in isolation and failure to eradicate resistant bacteria. Notably, concrete evidence that this current infection control approach actually prevents transmission is still lacking. We found that a novel approach with the training of infectious diseases specialists can reduce the usage of antimicrobials, thereby significantly decreasing the emergence of new MDROs. Moreover, increased hand hygiene compliance not only reduces transmission of MDROs, but also that of sensitive organisms causing the majority of nosocomial infections. Further, instruments, such as continuing education, bed-side observation, and the use of new tools, e.g. electronic wearables and Wi-Fi-equipped dispensers, are all options that can also improve the current low hand hygiene compliance levels. In addition, daily antiseptic body washes were observed to reduce the transmission of MDROs, especially those deriving from the body surface-like MRSA and VRE in specific settings. Finally, antiseptic body washes were seen to have similar effects on reducing transmission rates as screening and isolation measures. CONCLUSIONS: In summary, this review describes a novel evidence-based approach to counteract the growing medical challenge of increasing numbers of MDROs.


Assuntos
Gestão de Antimicrobianos , Controle de Infecções , Infecções/epidemiologia , Anti-Infecciosos/farmacologia , Anti-Infecciosos/uso terapêutico , Resistência Microbiana a Medicamentos , Resistência a Múltiplos Medicamentos , Humanos , Higiene , Controle de Infecções/métodos , Infecções/diagnóstico , Infecções/tratamento farmacológico , Infecções/etiologia , Programas de Rastreamento
4.
Infection ; 42(3): 545-8, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24515936

RESUMO

The purpose of this report was to assess the safety and application of chlorhexidine (CHG)-containing dressings--shown to reduce central line infection rates markedly--for external ventricular drainages (EVDs) and lumbar drainages (LDs). Cerebrospinal fluid samples of patients receiving standard dressings and CHG-containing dressing (ten each) were analyzed by high-performance liquid chromatography for the presence of CHG. The application was evaluated. CHG was not detectable in all samples. The dressings' application for EVDs and LDs worked without problems. Thus, the use of CHG-containing dressings for EVDs and LDs seems to be safe. Further studies addressing their infection reduction potential are warranted.


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Infecções Bacterianas/prevenção & controle , Bandagens/efeitos adversos , Derivações do Líquido Cefalorraquidiano/efeitos adversos , Clorexidina/uso terapêutico , Controle de Infecções/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anti-Infecciosos Locais/efeitos adversos , Anti-Infecciosos Locais/análise , Líquido Cefalorraquidiano/química , Clorexidina/efeitos adversos , Clorexidina/análise , Cromatografia Líquida de Alta Pressão , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Adulto Jovem
5.
Infection ; 42(1): 155-9, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23934685

RESUMO

PURPOSE: The reduction of central venous line (CVL)-associated bloodstream infections (CLABSIs) is generally advocated. However, despite implementing infection prevention recommendations, CLABSI rates remain high at some institutions. Therefore, a chlorhexidine-containing dressing should be assessed for its potential for infection reduction, adverse events (AEs) and practicability. METHODS: The number of CVLs, CVL days, CLABSIs and CLABSI rates with regard to the kind of dressing (standard vs. chlorhexidine-containing) were documented from November 2010 to may 2012 (1,298 patients with 12,220 CVL days) at two intensive care units (ICUs) and compared to historical controls. The practicability and safety of the chlorhexidine-containing dressing and reasons for not using this dressing were assessed. RESULTS: Forty CLABSIs occurred in 34 patients, resulting in a significantly lower overall CLABSI rate in patients with the chlorhexidine-containing dressing [1.51/1,000 CVL days; confidence interval (CI): 0.75-2.70] compared to patients with the standard dressing (5.87/1,000 CVL days; CI: 3.93-8.43; p < 0.0001). The CLABSI rate in historical controls receiving the standard dressing was 6.2/1,000 CVL days. The main reason for not using chlorhexidine-containing dressing was bleeding at the insertion site. AEs occurred in five patients and represented self-healing skin macerations (3 cases) and superficial skin necrosis (2 cases). CONCLUSIONS: In case of high CLABSI rates despite the implementation of standard recommendations, our findings suggest that a chlorhexidine-containing dressing safely decreases CLABSI rates.


Assuntos
Bandagens , Infecções Relacionadas a Cateter/epidemiologia , Infecções Relacionadas a Cateter/prevenção & controle , Cateterismo Venoso Central/efeitos adversos , Clorexidina/uso terapêutico , Desinfetantes/uso terapêutico , Controle de Infecções/métodos , Idoso , Cateterismo Venoso Central/métodos , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade
6.
J Hosp Infect ; 83 Suppl 1: S17-22, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23453171

RESUMO

Hand hygiene is considered to be the pillar of infection control and prevention. Despite national and international recommendations on hand hygiene, compliance remains low. Basic requirements allowing adequate hand hygiene compliance, in theory at least, are well known. Why then is it so hard to achieve acceptable compliance despite sufficient access to hand disinfectant dispensers, repeated training, and participation in national campaigns? Could it be that hand hygiene is regarded as too laborious, and changes to the established work-flow are needed to increase compliance? Some practicable examples are presented and pitfalls in defining compliance are discussed. Ownership for compliance must come from within clinical teams, and not solely driven from the infection control team. Support from the hospital management is essential. Ideally, the concepts presented allow a simple and efficient implementation of hand hygiene as part of the clinical work-flow to achieve an increase in compliance in the longer term.


Assuntos
Atitude do Pessoal de Saúde , Infecção Hospitalar/prevenção & controle , Fidelidade a Diretrizes/organização & administração , Higiene das Mãos/métodos , Higiene das Mãos/organização & administração , Fidelidade a Diretrizes/tendências , Hospitais Universitários , Humanos
7.
Infection ; 41(3): 675-80, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23435688

RESUMO

PURPOSE: In a previous observational intervention study, we achieved a more than 100 % increase in overall hand hygiene (HH) compliance in the hemodialysis setting by increasing the number of hand rubs (HR) performed and concomitantly optimizing HH standard operating procedures (SOPs). SOPs were mainly aimed at reducing the number of avoidable opportunities due to a less than perfect workflow. However, the long-term sustainability of this successful intervention was not evaluated. The present study was carried out to evaluate the long-term effects of our previous successful intervention. METHODS: We conducted a follow-up observational study 1 year after the first intervention study in the same hemodialysis unit to assess the sustainability. No HH-related interventions were performed in the 1 year between studies. The main outcome was HH compliance, and the secondary outcome was opportunities per hemodialysis procedure. RESULTS: A total of 1,574 opportunities for HH and 871 hand rubs (HR) were observed during the follow-up observational study. Overall, compliance was 55 %, which was significantly than that at the end of the first study (62 %; p < 0.0001), but significantly higher than that at the start and mid-term phases of the first study (37 and 49 %, p < 0.0001). Both the decrease in HH opportunities and the increase in HR were sustained over the course of this observational study. The number of avoidable opportunities in the present study was similar to that at the end of the previous study. Thus, in 320 opportunities (20 %), gloves were worn instead of HR performed, representing 46 % of all missed HR. CONCLUSIONS: Despite a decrease in HH compliance compared to the last postintervention period, a multifaceted intervention focusing on standardization and workflow optimization resulted in a sustained improvement in HH. We therefore propose that standardization of the hemodialysis workflow aimed at improving HH is a promising avenue for improving the quality of patient care and outcome.


Assuntos
Fidelidade a Diretrizes/estatística & dados numéricos , Higiene das Mãos/métodos , Controle de Infecções/métodos , Diálise Renal/efeitos adversos , Diálise Renal/métodos , Seguimentos , Higiene das Mãos/normas , Pesquisa sobre Serviços de Saúde , Humanos , Controle de Infecções/normas , Diálise Renal/normas , Fatores de Tempo
8.
Orthopade ; 41(1): 11-4, 2012 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-22273701

RESUMO

Individual patient risk factors for wound infections, such as alcohol abuse, smoking or obesity can usually only be modified to a small extent. Studies have shown a reduction of surgical site infections due to the implementation of a benchmarking surveillance system. In order to prevent surgical site infections a variety of interventions are available, such as glucose control, correction of anemia and malnutrition and antibiotic therapy of infections before elective surgery. Reduction of the microbial skin flora by whole body washing procedures, avoidance of sharp razor shaving, application of antibiotic prophylaxis and correct surgical hand disinfection are additional measures. Intraoperative hypothermia should be avoided and strict compliance with asepsis is mandatory. Postoperative preventive measures include appropriate wound care and rapid removal of wound drainage.


Assuntos
Antibacterianos/administração & dosagem , Infecções Bacterianas/diagnóstico , Infecções Bacterianas/prevenção & controle , Pré-Medicação/métodos , Infecção da Ferida Cirúrgica/diagnóstico , Infecção da Ferida Cirúrgica/prevenção & controle , Humanos
9.
Orthopade ; 41(1): 6-10, 2012 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-22273700

RESUMO

Surgical site infections are mainly caused by bacteria from the patients' skin or gut flora representing endogenous infections. In orthopedic and trauma surgery the skin commensals dominate and as a consequence Gram-positive bacteria are the main pathogens, particularly S. aureus. Additionally and especially in the case of foreign body infections, less virulent pathogens, e.g. coagulase-negative staphylococci play an important role. Due to newer microbiological techniques in detecting pathogens the spectrum of causative organisms is steadily increasing. As known for other nosocomial infections the relevance of multidrug resistant bacteria in surgical site infections is growing and the key player is methicillin-resistant S. aureus (MRSA); however vancomycin-resistant enterococci (VRE), extended spectrum betalactamases and/or carbapenemases producing enterobacteria and recently even panresistant Acinetobacter baumannii isolates have to be considered.


Assuntos
Antibacterianos/uso terapêutico , Infecções por Bactérias Gram-Positivas/microbiologia , Infecções por Bactérias Gram-Positivas/prevenção & controle , Pré-Medicação/métodos , Infecções Relacionadas à Prótese/microbiologia , Infecções Relacionadas à Prótese/prevenção & controle , Humanos
10.
Orthopade ; 41(1): 20-5, 2012 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-22273703

RESUMO

Periprosthetic knee joint infection is a rare complication. However, patients as well as surgeons have to deal with severe problems. The past years have brought new knowledge on periprosthetic knee joint infections which have resulted in new classifications. The present manuscript evaluates the current literature on this topic and presents a new therapeutic algorithm.


Assuntos
Algoritmos , Antibacterianos/uso terapêutico , Infecções Bacterianas/tratamento farmacológico , Prótese do Joelho/efeitos adversos , Pré-Medicação/métodos , Infecções Relacionadas à Prótese/tratamento farmacológico , Infecções Relacionadas à Prótese/prevenção & controle , Humanos
11.
Orthopade ; 41(1): 43-50, 2012 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-22273706

RESUMO

Chronic osteomyelitis is a severe complication characterized by soft tissue and bone pathogenic infection resulting in osseous destruction. Surgical management is demanding and poses a challenge in achieving the goals of treatment, which are control of infection, bone healing as well as satisfactory functional outcome. Therapeutic strategies are based on a combined application of radical surgery and systemic antibiotic therapy. The bony defects which remain after extensive debridement have to be reconstructed with bone grafting after soft tissue coverage and the healing process is decisive for a successful outcome.


Assuntos
Antibacterianos/uso terapêutico , Infecções Bacterianas/terapia , Transplante Ósseo , Desbridamento/métodos , Osteomielite/terapia , Osteotomia/métodos , Irrigação Terapêutica/métodos , Terapia Combinada , Humanos
12.
Unfallchirurg ; 115(1): 55-66, 2012 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-22274604

RESUMO

This review focuses on the presentation of the diagnostic and therapeutic principles for treatment of chronic osteomyelitis of long bones in adults. Early detection of the offending bacteria is a crucial step which has to be performed with tissue and fluids from the depth of the wound. Superficial samples and swaps from fistulas should be avoided and are not considered to be representative. Chronic osteomyelitis is characterized by necrotic and nonvascularized bony tissue which represents one of the most relevant sources for recurrence infection. Appropriate therapy includes radical excision of the diseased bone and infected scar tissue, closure of the wound with well-vascularized (muscle) flaps, stabilization, and administration of adequate antibiotics.


Assuntos
Infecções Bacterianas/tratamento farmacológico , Infecções Bacterianas/prevenção & controle , Osteomielite/diagnóstico , Osteomielite/terapia , Osteotomia/métodos , Adulto , Infecções Bacterianas/diagnóstico , Terapia Combinada/métodos , Humanos
13.
Infection ; 39(4): 359-62, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21717148

RESUMO

PURPOSE: Viral gastroenteritis is common on pediatric wards, increasing the need for adherence with hand hygiene recommendations in order to prevent cross-transmission. Therefore, we investigated hand hygiene reflecting complete work-day activities on pediatric wards and focused on the influence of viral gastroenteritis. There are, so far, no studies representing complete working days on pediatric wards or addressing the influence of viral gastroenteritis. METHODS: This was a prospective, observational study (144 h in each group) on hand hygiene behavior in the care for children with and without suspected or proven viral gastroenteritis. RESULTS: We documented 40 and 30 hand hygiene opportunities per patient-day for ward-associated healthcare workers for children with and without viral gastroenteritis, respectively (P = 0.316). Healthcare workers' compliance with hand hygiene recommendations was significantly higher in children with viral gastroenteritis compared to those without, i.e., 72 versus 67% (P = 0.033), especially among physicians, being 92 versus 50% (P = 0.032). Compliance tended to be higher after patient contact than before, especially in the children with gastroenteritis (78 vs. 62%; P = 0.083). CONCLUSIONS: We conclude that viral gastroenteritis seemed to increase the number of daily opportunities for hand hygiene and did significantly increase compliance. In particular, this effect was seen after patient contact. Further research might address the awareness of undiagnosed transmissible diseases in order to prevent cross-transmissions.


Assuntos
Infecção Hospitalar/prevenção & controle , Gastroenterite/prevenção & controle , Desinfecção das Mãos/normas , Corpo Clínico Hospitalar/normas , Recursos Humanos de Enfermagem Hospitalar/normas , Adulto , Criança , Criança Hospitalizada , Feminino , Alemanha , Fidelidade a Diretrizes/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Pessoal de Saúde , Humanos , Higiene , Controle de Infecções/normas , Transmissão de Doença Infecciosa do Profissional para o Paciente/prevenção & controle , Masculino , Corpo Clínico Hospitalar/psicologia , Recursos Humanos de Enfermagem Hospitalar/psicologia , Estudos Prospectivos
14.
J Hosp Infect ; 76(4): 320-3, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20970881

RESUMO

Hand hygiene is considered to be the single most effective measure to prevent healthcare-associated infection. Although there have been several reports on hand hygiene compliance, data on patients with multidrug-resistant (MDR) organisms in special isolation conditions are lacking. Therefore, we conducted a prospective observational study of indications for, and compliance with, hand hygiene in patients colonised or infected with meticillin-resistant Staphylococcus aureus (MRSA) or extended-spectrum ß-lactamase (ESBL)-producing enterobacteria in surgical intensive and intermediate care units. Hand disinfectant used during care of patients with MRSA was measured. Observed daily hand hygiene indications were higher in MRSA isolation conditions than in ESBL isolation conditions. Observed compliance rates were 47% and 43% for the MRSA group and 54% and 51% for the ESBL group in the surgical intensive care unit and the intermediate care unit, respectively. Compliance rates before patient contact or aseptic tasks were significantly lower (17-47%) than after contact with patient, body fluid or patient's surroundings (31-78%). Glove usage instead of disinfection was employed in up to 100% before patient contact. However, compliance rates calculated from disinfectant usage were two-fold lower (intensive care: 24% vs 47%; intermediate care: 21% vs 43%). This study is the first to provide data on hand hygiene in patients with MDR bacteria and includes a comparison of observed and calculated compliance. Compliance is low in patients under special isolation conditions, even for the indications of greatest impact in preventing healthcare-associated infections. These data may help to focus measures to reduce transmission of MDR bacteria and improve patient safety.


Assuntos
Infecção Hospitalar/prevenção & controle , Infecções por Enterobacteriaceae/prevenção & controle , Enterobacteriaceae/isolamento & purificação , Fidelidade a Diretrizes/estatística & dados numéricos , Desinfecção das Mãos/métodos , Staphylococcus aureus Resistente à Meticilina/isolamento & purificação , Infecções Estafilocócicas/prevenção & controle , Infecção Hospitalar/microbiologia , Desinfetantes/uso terapêutico , Infecções por Enterobacteriaceae/enzimologia , Infecções por Enterobacteriaceae/microbiologia , Luvas Cirúrgicas/estatística & dados numéricos , Humanos , Unidades de Terapia Intensiva , Estudos Prospectivos , Infecções Estafilocócicas/microbiologia , Centro Cirúrgico Hospitalar , beta-Lactamases/biossíntese
15.
Infection ; 38(5): 401-5, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20589523

RESUMO

BACKGROUND: Respiratory infection and failure is a commonly encountered problem in intensive care unit (ICU) patients. However, despite the accumulating body of evidence to suggest that herpes simplex virus type 1 (HSV-1) is associated with pneumonia, the exact role played by this virus in this process is still not fully understood. Therefore, to identify patients at risk, we have conducted a case-control study to characterize patients with HSV-1-positive pneumonia. PATIENTS AND METHODS: Between 2007 and 2009, all patients with suspected viral pneumonia were tested for the presence of herpes viruses using a PCR assay approach with respiratory specimens. To identify possible associations, risk factors, and impact of HSV, HSV-1-positive ICU patients (n = 51) were compared to age-, gender-, and department- and season-matched HSV-negative patients (n = 52). RESULTS: HSV-positive patients differed significantly from the HSV-negative ones only in terms of time of mechanical ventilation (13 vs. 6 days, respectively; p = 0.002). Subgroup analysis in the patients aged >60 years and in those without bacterial detection revealed a similar trend (p = 0.01 and p = 0.004, respectively). Mortality did not differ between the groups or between the HSV-1-positive patients treated with aciclovir and those who were not. A viral load >10E+05 geq/ml was associated with mechanical ventilation (20/21 vs. 17/29; p = 0.004), acute respiratory distress syndrome (ARDS; 19/21 vs. 18/29; p = 0.005), sepsis (18/21 vs. 14/29; p = 0.008), detection of a bacterial pathogen in the same specimen (10/21 vs. 4/29; p = 0.01) and longer ICU stay (25 vs. 30 days; p = 0.04). CONCLUSION: Despite several associations with high viral load, the clinical outcome of HSV-1-positive ICU patients did not differ significantly from the clinical outcome of HSV-negative patients. This finding indicates that HSV-1 viral loads in respiratory specimens are a symptom of a clinically poor condition rather than a cause of it. Longitudinal and therapy studies are therefore needed to distinguish between HSV-1 as a causative pathogen and HSV-1 as a bystander of pneumonia/ARDS.


Assuntos
Pneumonia Viral/virologia , Sistema Respiratório/virologia , Simplexvirus/isolamento & purificação , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Pneumonia Viral/mortalidade , Respiração Artificial/efeitos adversos , Simplexvirus/genética , Simplexvirus/fisiologia , Carga Viral
16.
Infection ; 38(3): 205-9, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20333433

RESUMO

BACKGROUND: Data on time-dependency of external ventricular drainage (EVD)- and lumbar drainage (LD)-associated meningoventriculitis (MV) are scarce and discussions on the subject are controversial; no data exist for infection rates (IR) relative to drainage-days. For this reason, we conducted an observational study to determine time-dependent IRs and to perform a risk factor analysis. PATIENTS AND METHODS: All patients (n = 210) requiring an EVD or LD during an 18-month period in 2007 and 2008 were enrolled and characterized. Data on type and duration of drainage, ICP measurement, number of drainage manipulations, hospital stay and time point of MV were analysed statistically. RESULTS: A total of 34 MV cases were reported with 17 for each kind of drainage accounting for an IR of 7.5 and 24.7 MV/1000 EVD- and LD-days, respectively. Of these, 28/34 MV (82%) occurred within the first 12 days, and IRs were highest between days 4 and 9. Longer drainage duration (>5 and >9 days, respectively) was correlated with a significant lower risk of MV (p = 0.03; p < 0.001). In this study, significant risk factors for MV were LD [vs. EVD, OR: 2.3 (1.1-4.7); p = 0.01], a previous MV [OR: 7.0 (2.1-23.3); p = 0.002], and neoplasm [OR: 11.6 (3.4-39); p = 0.001]. Simultaneous drainage, ICP and a previous drainage showed no influence on infection. CONCLUSION: To the best of our knowledge, this study is the first to provide data on time dependency of EVD- and LD-associated MV-IR based on drainage-days. However, because of the limited scale of our study, it would be desirable to confirm these results in a more powerful larger study. In conclusion, we recommend that future efforts should be made to better identify preventable risk factors as well as to define time periods of higher risk for the difficult-to-diagnose MV infection as a first step in profiling high risk patients.


Assuntos
Cateteres de Demora/efeitos adversos , Derivações do Líquido Cefalorraquidiano/efeitos adversos , Infecção Hospitalar/etiologia , Drenagem/efeitos adversos , Encefalite/etiologia , Meningite/etiologia , Candida albicans/isolamento & purificação , Infecções do Sistema Nervoso Central/etiologia , Infecções do Sistema Nervoso Central/microbiologia , Ventrículos Cerebrais/microbiologia , Distribuição de Qui-Quadrado , Infecção Hospitalar/microbiologia , Encefalite/microbiologia , Feminino , Bactérias Gram-Negativas/isolamento & purificação , Bactérias Gram-Positivas/isolamento & purificação , Humanos , Unidades de Terapia Intensiva , Região Lombossacral , Masculino , Meningite/microbiologia , Estudos Prospectivos , Fatores de Risco , Estatísticas não Paramétricas , Fatores de Tempo
17.
Infection ; 36(1): 31-5, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18231721

RESUMO

BACKGROUND: Bloodstream infections (BSI) with gram-negative bacteria (GNB) are one of the most serious infections in the hospital setting, a situation compounded by the increasing antibiotic resistance of gram-negative bacteria causing BSI. The aim of the study was to assess the impact of antibiotic multiresistance of GNB in BSI on mortality rates and length of stay (LOS). MATERIALS AND METHODS: The setting was the University Hospital Aachen, a 1,500-bed tertiary-care hospital with over 100 ICU beds providing maximal medical care in all disciplines. We performed a 5-year hospital-wide matched cohort study (January 1996 to February 2001) in which 71 cases and 99 controls were enrolled. Matching criteria were sex, age and GNB isolated in blood cultures. Multiresistance was defined as resistance against at least two different classes of antibiotics such as penicillins (+beta-lactamase-inhibitor), third-generation cephalosporins, fluoroquinolones or carbapenems. RESULTS: BSI were mainly nosocomially acquired, and cases of BSI with multiresistant bacteria were associated with a higher mortality (p=0.0418) and a prolonged LOS in the intensive care unit (ICU) (p=0.0049). Risk factors for BSI with multiresistant GNB were antibiotic treatment (p=0.0191) and mechanical ventilation (p=0.0283). CONCLUSION: Multiresistance of GNB causing BSI was associated with higher mortality rates and longer LOS in ICU. The initial antibiotic therapy was significantly more often inadequate and might have had an impact on overall mortality. Thus, an effective strategy to administer an appropriate initial empirical antibiotic therapy, especially in patients with risk factors, must be sought. Moreover, the overall usage of antimicrobials must be limited and infection control guidelines should be followed to reduce the emergence and transmission of multiresistant GNB.


Assuntos
Bacteriemia/microbiologia , Farmacorresistência Bacteriana Múltipla , Bactérias Gram-Negativas/efeitos dos fármacos , Infecções por Bactérias Gram-Negativas/microbiologia , Idoso , Antibacterianos/uso terapêutico , Bacteriemia/tratamento farmacológico , Bacteriemia/mortalidade , Estudos de Coortes , Feminino , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Infecções por Bactérias Gram-Negativas/mortalidade , Humanos , Tempo de Internação , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Fatores de Risco
18.
Anaesthesist ; 54(10): 1047-64; quiz 1065-6, 2005 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-16211405

RESUMO

Invasive fungal infections are associated with a high mortality and have been increasing in incidence over the last few decades. Candidemia and, less commonly, invasive pulmonary aspergillosis are the most relevant fungal infections in critical care medicine. Risk factors for systemic Candida infections are the use of broad-spectrum antibiotics, a prolonged stay in an intensive care unit and gastrointestinal injury or surgery. Invasive aspergillosis usually occurs in immunocompromised patients. The diagnosis of invasive fungal infections remains challenging. The therapeutic spectrum includes fluconazol, conventional and liposomal amphotericin B, and the recently introduced agents caspofungin and voriconazol. For rational and cost-effective use, the clinician requires precise knowledge of the indications and limitations of these agents. This review focuses on the diagnostic and therapeutic options in severe Candida infections and invasive aspergillosis.


Assuntos
Antifúngicos/uso terapêutico , Unidades de Terapia Intensiva , Micoses/diagnóstico , Micoses/tratamento farmacológico , Doença Aguda , Antifúngicos/efeitos adversos , Aspergilose/tratamento farmacológico , Aspergilose/microbiologia , Candidíase/tratamento farmacológico , Candidíase/microbiologia , Doença Crônica , Humanos , Micoses/microbiologia
19.
Infection ; 33(3): 115-21, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15940411

RESUMO

BACKGROUND: We assessed data on the epidemiology of nosocomial infections (NIs) in a 14-bed neurosurgical intensive care unit (NSICU) and used surveillance data for the promotion of quality improvement activities. PATIENTS AND METHODS: Prospective periodic surveillance was performed over five 3-month periods between July 1998 and October 2002 on all patients admitted with a length of stay > 24 hours. RESULTS: 763 patients with a total of 4,512 patient days and a mean length of stay of 5.9 days were enrolled within the 15-month study period. A total of 93 NIs were identified in 82 patients. Urinary tract infections (24.7%), pneumonia (23.6%), and bloodstream infections (17.2%) were the most frequent NIs recorded. Device-associated incidence rates were 6.0 (3.8-9.0, CI(95%)) for urinary tract infection, 4.4 (2.4-7.4, CI(95%)) for bloodstream infection, and 10.3 (6.3-15.9, CI(95%)) for pneumonia per 1,000 days at risk. For improvement of infection control-related processes, evidence-based infection control guidelines were established and an NSICU nurse was designated to be responsible for infection control issues on the ward. In addition, several infection control problems arose during the observation periods and were rapidly responded to by introducing specific intervention strategies. CONCLUSION: Periodic surveillance is a valuable tool for assessing the epidemiology of NIs in the NSICU setting as well as for promoting the initiation of quality improvement activities.


Assuntos
Infecção Hospitalar/epidemiologia , Infecção Hospitalar/prevenção & controle , Unidades de Terapia Intensiva/normas , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos , Vigilância da População , Estudos Prospectivos , Garantia da Qualidade dos Cuidados de Saúde , Fatores de Risco
20.
Chemotherapy ; 50(1): 27-30, 2004 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15084802

RESUMO

BACKGROUND: The serum bactericidal test measures the highest level of an antibiotic-containing serum dilution at which 99.9% of bacteria are killed. In this study the serum bactericidal activity of piperacillin/tazobactam was determined for bacteria often involved in severe infections. In earlier studies titres >/=1:8 in the serum bactericidal tests correlated well with clinical success in the treatment of endocarditis and osteomyelitis as well as bacterial eradication. METHODS: Blood samples of 6 healthy volunteers were taken before and 1 and 4 h after piperacillin/tazobactam (4.5 g) administration. Serum concentrations and serum bactericidal activity were determined for 10 strains each of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, both piperacillin-resistant and piperacillin-susceptible according to NCCLS guidelines. RESULTS: 100% of S. aureus and piperacillin-susceptible E. coli, 90% of piperacillin-resistant E. coli and 80% of P. aeruginosa were killed 1 h after drug administration. 4 h after drug administration serum bactericidal activity decreased to 60% for S. aureus, 90% for piperacillin-susceptible E. coli, 80% for piperacillin-resistant E. coli and 30% for P. aeruginosa. CONCLUSIONS: Excellent serum bactericidal activity of piperacillin/tazobactam was recorded 1 h after drug administration for S. aureus, E. coli and P. aeruginosa. After 4 h limited killing rates for P. aeruginosa could be detected, which supports the idea of a combination therapy.


Assuntos
Antibacterianos/farmacologia , Escherichia coli/efeitos dos fármacos , Ácido Penicilânico/análogos & derivados , Ácido Penicilânico/farmacologia , Piperacilina/farmacologia , Pseudomonas aeruginosa/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Adulto , Antibacterianos/sangue , Quimioterapia Combinada , Feminino , Humanos , Masculino , Testes de Sensibilidade Microbiana , Ácido Penicilânico/sangue , Resistência às Penicilinas , Piperacilina/sangue , Tazobactam
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