Visual perspective taking and action understanding.

Understanding what others are doing is a fundamental aspect of social cognition and a skill that is arguably linked to visuospatial perspective taking (VPT), the ability to apprehend the spatial layout of a scene from another's perspective. Yet, with few and notable exceptions, action understanding and VPT are rarely studied together. Participants (43 females, 37 males) made judgements about the spatial layout of objects in a scene from the perspective of an avatar who was positioned at 0°, 90°, 270° or 180° relative to the participant. In a variant of a traditional VPT task, the avatar either interacted with the objects in the scene, by pointing to or reaching for them, or was present but did not engage with the objects. Although the task was identical across all conditions - to say whether a target object is to the right or left of a control object - we show that the avatar's actions modulates performance. Specifically, participants were more accurate when the avatar engaged with the target object, and correspondingly, less accurate and slower when the avatar interacted with the control objects. As these effects were independent of the angular disparity between participant and avatar perspectives, we conclude that action understanding and VPT are likely linked via the rapid deployment of two separate cognitive mechanisms. All participants provided a measure of self-reported empathy and we show that response times decrease with increasing empathy scores for female but not for male participants. However, within the range of 'typical' empathy scores, defined here as the interquartile range where 50 % of the data lie, females were faster than males. These findings lend further insight into the relationship between spatial and social perspective taking.

Microplastics in human blood: Polymer types, concentrations and characterisation using µFTIR.

Microplastics (MPs) are an everyday part of life, and are now ubiquitous in the environment. Crucially, MPs have not just been found within the environment, but also within human bodies, including the blood. We aimed to provide novel information on the range of MP polymer types present, as well as their size and shape characteristics, in human whole blood from 20 healthy volunteers. Twenty-four polymer types were identified from 18 out of 20 (90 %) donors and quantified in blood, with the majority observed for the first time. Using an LOQ approach, five polymer types met the threshold with a lower mean ± SD of 2466 ± 4174 MP/L. The concentrations of plastics analysed in blood samples ranged from 1.84 - 4.65 µg/mL. Polyethylene (32 %), ethylene propylene diene (14 %), and ethylene-vinyl-acetate/alcohol (12 %) fragments were the most abundant. MP particles that were identified within the blood samples had a mean particle length of 127.99 ± 293.26 µm (7-3000 µm), and a mean particle width of 57.88 ± 88.89 µm (5-800 µm). The MPs were predominantly categorised as fragments (88 %) and were white/clear (79 %). A variety of plastic additive chemicals were identified including endocrine disrupting-classed phthalates. The procedural blank samples comprised 7 polymer types, that were distinct from those identified in blood, mainly resin (25 %), polyethylene terephthalate (17 %), and polystyrene (17 %) with a mean ± SD of 4.80 ± 5.59 MP/L. This study adds to the growing evidence that MPs are taken up into the human body and are transported via the bloodstream. The shape and sizes of the particles raise important questions with respect to their presence and associated hazards in terms of potential detrimental impacts such as vascular inflammation, build up within major organs, and changes to either immune cell response, or haemostasis and thrombosis.

Alternative Methods for the Detection of Superoxide Anion Generation in Platelets.

Reactive oxygen species (ROS) are highly unstable oxygen-containing molecules. Their chemical instability makes them extremely reactive and gives them the ability to react with important biological molecules such as proteins, nucleic acids, and lipids. Superoxide anions are important ROS generated by the reduction of molecular oxygen reduction (i.e., acquisition of one electron). Despite their initial implication exclusively in aging, degenerative, and pathogenic processes, their participation in important physiological responses has recently become apparent. In the vascular system, superoxide anions have been shown to modulate the differentiation and function of vascular smooth muscle cells, the proliferation and migration of vascular endothelial cells in angiogenesis, the immune response, and the activation of platelets in hemostasis. The role of superoxide anions is particularly important in the dysregulation of platelets and the cardiovascular complications associated with a plethora of conditions, including cancer, infection, inflammation, diabetes, and obesity. It has, therefore, become extremely relevant in cardiovascular research to be able to effectively measure the generation of superoxide anions by human platelets, understand the redox-dependent mechanisms regulating the balance between hemostasis and thrombosis and, eventually, identify novel pharmacological tools for the modulation of platelet responses leading to thrombosis and cardiovascular complications. This study presents three experimental protocols successfully adopted for the detection of superoxide anions in platelets and the study of the redox-dependent mechanisms regulating hemostasis and thrombosis: 1) dihydroethidium (DHE)-based superoxide anion detection by flow cytometry; 2) DHE-based superoxide anion visualization and analysis by single platelet imaging; and 3) spin probe-based quantification of superoxide anion output in platelets by electron paramagnetic resonance (EPR).

Actions are characterized by 'canonical moments' in a sequence of movements.

Understanding what others are doing is an essential aspect of social cognition that depends on our ability to quickly recognize and categorize their actions. To effectively study action recognition we need to understand how actions are bounded, where they start and where they end. Here we borrow a conceptual approach - the notion of 'canonicality' - introduced by Palmer and colleagues in their study of object recognition and apply it to the study of action recognition. Using a set of 50 video clips sourced from stock photography sites, we show that many everyday actions - transitive and intransitive, social and non-social, communicative - are characterized by 'canonical moments' in a sequence of movements that are agreed by participants to 'best represent' a named action, as indicated in a forced choice (Exp 1, n = 142) and a free choice (Exp 2, n = 125) paradigm. In Exp 3 (n = 102) we confirm that canonical moments from action sequences are more readily named as depicting specific actions and, mirroring research in object recognition, that such canonical moments are privileged in memory (Exp 4, n = 95). We suggest that 'canonical moments', being those that convey maximal information about human actions, are integral to the representation of human action.1.

Children grow upwards, and so does the number line: Evidence from a directional number line paradigm.

Technological advancements give researchers the opportunity to explore the internal metric that allows to mentally place numbers in a spatial and ordered way to establish relationships between quantities. In this study, we implement the cMNL, an embodied number line paradigm to investigate the configuration of children's number space mappings under multiple conditions. A sample of 185 primary school children aged 8-10years old completed digitally an embodied number line task encompassing directionality and modality as variables. Contrary to the premise of a fixed internal number line moving from left to right in many Western scripts, our results suggest that children's number-space mapping is more robust along a vertical axis. In addition, children's embodied number line estimation differed depending on input modality. The findings provide insight into the variability in children's number line estimation, and the usability of digital assessment in understanding the mechanisms of the developing number-space system.

Information on cosmic radiation received by Belgian aircrew: a survey.

Exposure of aircrew to cosmic radiation had already been identified as an issue of concern in the European BSS of 1996 which requested airlines to assess the exposure of the crew and to inform their workers of the health risks their work involves. These requirements have been implemented in Belgian regulations in 2001 and updated with the transposition of the 2013/59/Euratom directive. Dosimetry data show that aircrew is the group of workers, which contributes the most to the collective dose of occupationally exposed workers in Belgium. In order to verify the extent of the information received by Belgian aircrew regarding their exposure to cosmic radiation, FANC, the Belgian radiation protection authority, launched in 2019 a large survey in collaboration with the Belgian Cockpit Association (BeCA), the professional association representing airline pilots in Belgium. The survey included 8 questions regarding the information of aircrew on cosmic radiation in general, on the individual dose level and on the risk related to exposure during pregnancy. A total of about 400 responses to the survey were received. Overall, the survey reveals that aircrew members in Belgium receive too little information about the potential risks, that they are not sufficiently informed about their own exposure and that female staff members are insufficiently informed about the hazards for the unborn child in case of pregnancy, and 66% of the respondents answered that their employer has never informed them about their exposure to cosmic radiation. However, most are aware of this phenomenon, either because they have looked up information or because they have discussed the topic with colleagues and professional associations. The results also showed that 17% of female crew continued to fly while being pregnant. Finally, the survey also allowed to identify differences and similarities between different groups of workers: cockpit and cabin crew, men and women. For instance, cabin crew was even less informed about their individual exposure than cockpit crew.

New technologies promoting active upper limb rehabilitation after stroke: an overview and network meta-analysis.

INTRODUCTION: The primary aim of this work was to summarize and compare the effects of active rehabilitation assisted by new technologies (virtual reality [VR], robot-assisted therapy [RAT] and telerehabilitation [TR)) on upper limb motor function and everyday living activity during the subacute and chronic phases of stroke. The secondary aims were to compare the effects of these technologies according to the intervention design (in addition to or in substitution of conventional therapy), the duration of active rehabilitation and the severity of patients' motor impairments. EVIDENCE ACQUISITION: Several databases, namely PubMed, Scopus, Embase and Cochrane Library, were searched. Studies were included if they were meta-analyses with a moderate to high level of confidence (assessed with AMSTAR-2) that compared the effects of a new technology promoting active rehabilitation to that of a conventional therapy program among patients with stroke. Network meta-analyses were conducted to compare the effects of the new technologies. EVIDENCE SYNTHESIS: Eighteen different meta-analyses were selected and fifteen included in the quantitative analysis. In total these 15 meta-analyses were based on 189 different randomized controlled trials. VR (SMD≥0.25; P<0.05), RAT (SMD≥0.29; P≤0.29) and TR (SMD≥-0.08; P≤0.64) were found to be at least as effective as conventional therapy. During the subacute phase, RAT's greatest effect was observed for patients with severe-moderate impairments whereas VR and TR's greatest effects were observed for patients with mild impairments. During the chronic phase, the highest effects were observed for patients with mild impairments, for all studies technologies. Network meta-analyses showed that VR and RAT were both significantly superior to TR in improving motor function during the chronic phase but revealed no significant difference between VR, RAT and TR effectiveness on both motor function (during the subacute phase) and activity (during both chronic and subacute phase). CONCLUSIONS: This overview provides low-to-moderate evidence that rehabilitation assisted with technologies are at least as effective as conventional therapy for patients with stroke. While VR and RAT seem to be more efficient during the subacute phase, all technologies seem to be as efficient as one another in the chronic phase.

Educational achievement and bullying: The mediating role of psychological difficulties.

BACKGROUND: Bullying has a profound and enduring impact on academic achievement. However, there is a lack of clarity surrounding the specific mechanisms of this relationship. AIMS: This study examined the link between bullying at age 9 and Numeracy/Literacy achievement at age 15 to determine if this relationship is partially or fully explained by psychological difficulties at age 13. SAMPLE: Secondary data analysis was completed on waves 1, 2 and 3 of child cohort (Cohort'98) of the Growing Up in Ireland (GUI) study, respectively, at 9 years (N = 8568), 13 years (N = 7527) and 15 years of age (N = 6216). RESULTS: Longitudinal path mediation model was conducted with bullying at age 9 as the predictor, total (emotional and behavioural) difficulties at age 13 as the mediator and Numeracy/Literacy scores at age 15 as outcomes revealing significant indirect effects of bullying on achievement, via psychological difficulties. CONCLUSIONS: We discuss the impact of bullying on the student's psychological well-being, the relationship between bullying and academic attainment and how this may be tackled to avoid consequences throughout education and later in life. EDUCATIONAL IMPACT AND IMPLICATIONS: This study emphasizes the need for schools to address the emotional and behavioural difficulties occurring as a result of bullying in order to improve the overall educational experience of a child. Existing interventions can be built upon by focusing on the continuous remediation of such psychological difficulties.

Mediating factors of statistics anxiety in university students: a systematic review and meta-analysis.

Statistics plays a key role in many areas of modern society, including technology, social and behavior studies, economics, and the sciences. Statistics anxiety (SA) has a detrimental impact on academic experiences in university populations, although the mediating factors remain underexplored. We conducted the first systematic review and meta-analysis focused on SA in university students in the context of statistical performance, individual differences in statistical learning, self-perceptions regarding the statistics course and instructor, and sociodemographic factors. Searches were carried out in the PsycINFO, PubMed, Scielo, and Web of Science databases according to our preregistration. Forty studies were selected for systematic review. Seventeen were included in a series of six meta-analyses concerning academic achievement, attitudes, self-perception, procrastination, and gender. The findings reveal learning strategies, procrastination, self-efficacy, and self-awareness as predictors of SA. However, the impact of sociodemographic data in these moderators is still uncharted. We conclude with a critical appraisal of the selected studies and present future directions for research in SA.