[What contributes to the transformation of Helicobacter pylori from symbiont into the etiopathogenetical factor of duodenal ulcer?].

UNLABELLED: The aim was to study the relationship duodenogastral reflux (DGR) and Helicobacterpylori infection (Hp) at duodenal ulcer (DU). MATERIAL AND METHODS: Group 1-50 patients with uncomplicated course of DU, Group 2-75 patients with destructive complications of DU; Group 3-40 "healthy" volunteers. It was performed daily EGDS, pH meter, semi-quantitative assessment of contamination of the Hp. RESULTS: The acidity in the body of the stomach was highest in group 2, and lowest--in group 3, patients diagnosed DU night rush giperatsidnosti. In the night period patients from the 1st and 3rd groups were recorded an increase of antral pH, including the expense of growth duration of DGR, while in group 2 reflux was extremely short. The maximum Hp dissemination was in a bulb at fetomaternal of DU. CONCLUSIONS: in healthy individuals DGR intragastral involved in the regulation of pH, in patients with uncomplicated DU while reducing the duration of this resonance persists compensation of antral alkalization, and complications throughout the DGR sharply depressed, which is accompanied by severe decompensation alkalization of antrum. Bulbs semination with Hp inversely proportional to the intensity of this resonance.

[Painful syndrome in patients with ulcer disease in relation to intragastric pH].

Painful abdominal syndrome and diurnal fluctuations of pH values were investigated in 125 patients with different clinical variants of duodenal ulcer disease (DUD) in the phase of exacerbation. Fifty patients had uncomplicated DUD; it was complicated in the remaining 75 patients. The clinical course of the uncomplicated disease was characterized by moderate to severe painful hyperacidity syndrome coincident with the period of exacerbation, marked daily variations of pH, and manifest duodenogastric reflux (DGR). These made the patients opportunely apply for medical aid while acidification and alkalinization processes in the stomach prevented the development of complications. The complicated disease was associated with short-term pain or its absence, monotonic diurnal variations of acid production and alkalinization, weak DGR. Taken together, these clinical features explain why such patients less frequently apply for medical aid and eventually develop destructive complications.

[Clinical significance of "night acid burst" phenomenon in patients with duodenal ulcer].

The article discloses the results of the examination and treatment of duodenal ulcer patients with or without "nocturnal gastric acid breakthrough". This phenomenon was recorded in 19% patients. They have night heartburn, complicated duodenal ulcer in anamnesis, on the one hand, and more long duration of ulcer healing, decreasing efficiency of eradication Helicobacter pylori, on the other hand.

[Characteristics of the psychological status of patients with peptic ulcer].

The article discusses changes in the psychological status and the forming of various types of attitude towards the disease in patients with a favorable and unfavorable course of peptic ulcer (PU). The subjects of the study were 82 patients with exacerbation of PU; among them there were 30 patients with a favorable and 52 patient with a complicated course. Patients with a favorable course of PU did not displayed prominent peaks in SMOL profile, which reflected a relatively benign state of their psychological status. Favorable type of response to the disease--harmonic and anosognostic--with lesser social disadaptation prevailed in these patients. On the contrary, patients with a complicated course of PU displayed a relative increase in the profile on the scales, reflecting a higher tension in combination with diadaptive response to the disesase, which should be taking into account when correcting treatment.

[On correlations between the clinical course of peptic ulcer and the patients, compliance and quality of life].

The article is dedicated to changes in life quality (LQ) and mental status, and to forming of various types of response to the disease in patients with benign and unfavorable course of peptic ulcer (PU). The subjects were 140 patients in acute phase of PU, in 66 of whom the course of the disease was benign, and in 74--unfavorable. In both groups there were patients with low and satisfactory LQ. High level of nervousness was typical of patients with low LQ and benign course of the disease. Patients with satisfactory LQ and unfavorable course of the disease were characterized by minor personality changes, but developed an agnostic response to the disease much more frequently. Reduction of compliance was found mainly in patients with low LQ and an agnostic response; this should be taken into consideration while correcting the therapy.