[Morphological changes in the ocular structures in the simulation of proliferative vitreoretinopathy and in the presence of an extraocular focus of chronic infection].

The pathomorphological features of proliferative vitreoretinopathy (PVR) were studied in the presence or absence of an extraocular focus of chronic infection. The study was performed on 60 Chinchilla rabbits. In experimental animal group 1, the left eyes were used to simulate a thrombocytic model of PVR; physiological sodium chloride solution was injected into the right eyes that served as control. In Group 2 animals, a chronic infection focus had been previously reproduced by subcutaneously injecting 0.2 ml of BGC vaccine into the nasal bridge and PVR was simulated 2 weeks later. A comparative study of hematoxylin- and eosin-stained histological specimens from the eyes of Groups 1 and 2 animals, a study of the cellular composition on semithin sections, and electron microscopy showed a poor course of the proliferative process in the presence of an extraocular focus of chronic infection. In the presence of a chronic infection focus, PVR is constantly maintained; it takes a severer course for a longer period while in its absence the proliferative process tends to regress.

[Ultrastructure of optic nerve fibers in rabbits after intravitreal infusion of perfluoroorganic compounds].

Ultrastructure of optic nerve myelinated fibers after intravitreal infusion of perfluorooctylbromide (PFOB) and perfluorodecaline (PFD) for 30 days was studied in rabbits (n = 14). After inraocular administration of PFOB, the ultrastructural changes of optic nerve fibers were mainly reactive in nature. Mitochondrial swelling and partial destruction of cristae were detected in the axons. After PFD infusion, the changes were observed that were not only reactive, but highly degenerative, including destruction of organelles and myelin sheath and axon cytoskeleton disintegration. Thus, the changes associated with PFOB were less pronounced than those found after PFD application. Therefore, PFOB is more promising for the use as an ophthalmologic implant.